Results 281 to 290 of about 234,915 (329)

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

open access: yesAdvanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang   +15 more
wiley   +1 more source

Western Diet Inhibits FUT7‐Mediated Treg Intestinal Homing to Disrupt the Homeostasis of Intestinal Epithelial Cells in Crohn's Disease

open access: yesAdvanced Science, EarlyView.
In this study, we constructed a nanoparticle that was CD4 antibody‐mediated targeted, Fut7‐expressing plasmid‐loaded cationic liposome, namely CD4‐LDP‐Fut7. Upregulation of Fut7 expression in Tregs by using CD4‐LDP‐Fut7 can increase Treg homing to the intestine, thereby facilitating repair of the intestinal epithelial barrier and inhibiting ...
Qian Zhou   +13 more
wiley   +1 more source

Biomarkers of Intestinal Permeability Are Influenced by Diet in Patients with Ulcerative Colitis-An Exploratory Study. [PDF]

open access: yesDiagnostics (Basel)
Haskey N   +8 more
europepmc   +1 more source

Burn‐Safe Biodegradable Magnetocaloric Composites for Temperature‐Controlled Biomedical Applications

open access: yesAdvanced Science, EarlyView.
This work investigates a magnetocaloric (Mn,Fe)2(P,Si) compound tailored for precise, self‐regulating heating in biomedical use. With a Curie temperature tuned at 43 °C, it enables therapeutic activation without overheating. Encapsulation in a composite ensures controlled temperature rise under an alternating magnetic field (AMF), with high ...
Pornpawee Uliss   +8 more
wiley   +1 more source

Egg supplementation for 24 weeks does not improve linear growth or reduce small intestinal permeability in Sierra Leonean children with moderate wasting: a randomized, blinded, controlled trial. [PDF]

open access: yesAm J Clin Nutr
Stephenson KB   +11 more
europepmc   +1 more source

Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review

open access: yesAdvanced Science, EarlyView.
Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao   +4 more
wiley   +1 more source

Evaluation of Intestinal Permeability Using Serum Biomarkers in Learning Early About Peanut Allergy Trial. [PDF]

open access: yesAllergy
Aktas ON   +11 more
europepmc   +1 more source

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