Results 151 to 160 of about 819,681 (335)

Real‐World Performance of FIT Triage for Symptomatic Colonoscopy: Analysis of the UK National Endoscopy Database (NED)

open access: yesAlimentary Pharmacology &Therapeutics, EarlyView.
National endoscopy data show that FIT‐based triage clearly outperforms symptom‐based referral for colorectal cancer risk stratification. FIT ≥ 10 identifies high‐risk symptomatic patients, while FIT < 10 confers very low cancer risk, supporting FIT as the primary tool for prioritising colonoscopy in symptomatic pathways.
David Beaton   +4 more
wiley   +1 more source

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

open access: yesBritish Journal of Pharmacology, EarlyView.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi   +10 more
wiley   +1 more source

Diagnostic value of methane-hydrogen breath test combined with intestinal flora testing in screening for colorectal polyps

open access: yesFrontiers in Medicine
PurposeDiagnostic value of Methane and Hydrogen Breath Test (MHBT) combined with intestinal flora detection in colorectal polyp screening.MethodsRetrospective inclusion of 196 patients who had completed MHBT with colonoscopy during the same period of ...
Wei Wang   +12 more
doaj   +1 more source

Fluorescence lifetime spectroscopy of tissue autofluorescence in normal and diseased colon measured ex vivo using a fiber-optic probe

open access: yes, 2013
We present an ex vivo study of temporally and spectrally resolved autofluorescence in a total of 47 endoscopic excision biopsy/resection specimens from colon, using pulsed excitation laser sources operating at wavelengths of 375 nm and 435 nm.
Chorvat   +65 more
core   +1 more source

Modifiable Risk Factors for Symptom Burden in Chronic Rhinosinusitis With Nasal Polyps: The Role of Obesity and Sleep Apnoea

open access: yesClinical Otolaryngology, EarlyView.
ABSTRACT Objective To identify sociodemographic and clinical predictors of symptom severity and quality of life (QoL) impairment in patients with chronic rhinosinusitis with nasal polyps (CRSwNP), diagnosed according to the latest EPOS 2020 criteria. Study Design Cross‐sectional analytical study.
Javier Modesto García‐Fernández   +5 more
wiley   +1 more source

Gastroenterological disorders and hepatic disease in adults with cerebral palsy: A systematic review

open access: yesDevelopmental Medicine &Child Neurology, EarlyView.
Abstract Aim To describe the incidence, prevalence, and prognostic factors for gastroenterological disorders and hepatic disease in adults with cerebral palsy (CP), and to examine the effectiveness of any screening or interventions. Method Six databases were searched for articles published in any language since 1990 meeting eligibility criteria ...
Christina M. Marciniak   +18 more
wiley   +1 more source

Vaspin identified as a DNA‐binding serpin with functional consequences for protease inhibition

open access: yesThe FEBS Journal, EarlyView.
Vaspin is a serpin that is expressed in skin, adipose tissue, and liver. It binds to single‐ and double‐stranded DNA with high affinity. This binding is unaffected by mutation of the known heparin‐binding site, accelerates the inhibition of the inflammatory protease KLK7, and may contribute to vaspin's nuclear localization.
Kevin Möhlis   +9 more
wiley   +1 more source

Interobserver variability of histopathological assessment in pT1 colorectal carcinoma

open access: yesHistopathology, EarlyView.
Interobserver variability among 20 gastrointestinal pathologists was evaluated on 80 pT1 colorectal carcinoma cases. A pilot phase was followed by a consensus meeting, then a larger concordance study was performed. High interobserver agreement was achieved after consensus for histological grade, lymphovascular invasion, tumour budding, poorly ...
Karmele Saez de Gordoa   +24 more
wiley   +1 more source

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