Results 41 to 50 of about 244,058 (306)

Metabolic Teamwork in the Stem Cell Niche [PDF]

, 2018
Nearby cells can support stem cell differentiation, but the metabolic activities in stem cell niches are unknown. A recent study (Rodríguez-Colman et al., 2017) reveals a metabolic partnership in the intestinal stem cell niche: glycolysis in niche Paneth
Roper, Jatin, Yilmaz, Omer
core   +1 more source

Mesenchymal stem cells stimulate intestinal stem cells to repair radiation-induced intestinal injury [PDF]

Cell Death & Disease, 2016
AbstractThe loss of stem cells residing in the base of the intestinal crypt has a key role in radiation-induced intestinal injury. In particular, Lgr5+ intestinal stem cells (ISCs) are indispensable for intestinal regeneration following exposure to radiation.
Gong, Wei, Guo, Mengzheng, Han, Zhibo, Wang, Yan, Yang, Ping, Xu, Chang, Wang, Qin, Du, Liqing, Li, Qian, Zhao, Hui, Fan, Feiyue, Liu, Qiang   +11 more
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DNA replication licensing in stem cells: Gatekeeping the commitment to proliferation. [PDF]

, 2018
Carroll et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201708023) developed a method to assess DNA replication licensing in tissues. They show that intestinal stem cells within wild-type crypts, but not in crypts with cancer-causing mutations ...
Coller, Hilary A
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Plasticity of differentiated cells in wound repair and tumorigenesis, Part II: Skin and intestine [PDF]

, 2018
Recent studies have identified and begun to characterize the roles of regenerative cellular plasticity in many organs. In Part I of our two-part Review, we discussed how cells reprogram following injury to the stomach and pancreas.
Burclaff, Joseph, Mills, Jason C
core   +2 more sources

PTEN-deficient intestinal stem cells initiate intestinal polyposis [PDF]

Nature Genetics, 2007
Intestinal polyposis, a precancerous neoplasia, results primarily from an abnormal increase in the number of crypts, which contain intestinal stem cells (ISCs). In mice, widespread deletion of the tumor suppressor Phosphatase and tensin homolog (PTEN) generates hamartomatous intestinal polyps with epithelial and stromal involvement.
Xi C, He, Tong, Yin, Justin C, Grindley, Qiang, Tian, Toshiro, Sato, W Andy, Tao, Raminarao, Dirisina, Kimberly S, Porter-Westpfahl, Mark, Hembree, Teri, Johnson, Leanne M, Wiedemann, Terrence A, Barrett, Leroy, Hood, Hong, Wu, Linheng, Li   +14 more
openaire   +2 more sources

Paneth Cells: Dispensable yet Irreplaceable for the Intestinal Stem Cell NicheSummary

Cellular and Molecular Gastroenterology and Hepatology
Intestinal stem cells replenish the epithelium throughout life by continuously generating intestinal epithelial cell types, including absorptive enterocytes, and secretory goblet, endocrine, and Paneth cells. This process is orchestrated by a symphony of
Michaela Quintero, Linda C. Samuelson
doaj   +1 more source

Intestinal stem cells promote crypt fission during postnatal growth of the small intestine

BMJ Open Gastroenterology, 2020
Objective Wnt-β-catenin signalling is essential for intestinal stem cells. Our aim was to investigate the relationship between intestinal stem cells and crypt fission which peaks during infancy.Design Duodenal biopsies were obtained during endoscopy to ...
Zenab Mustansir Dudhwala, Paul D Hammond, Gordon S Howarth, Adrian Gerard Cummins   +3 more
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Canonical Wnt signals combined with suppressed TGFβ/BMP pathways promote renewal of the native human colonic epithelium [PDF]

, 2013
Background: A defining characteristic of the human intestinal epithelium is that it is the most rapidly renewing tissue in the body. However, the processes underlying tissue renewal and the mechanisms that govern their coordination have proved difficult ...
Ahmed El Hadi, Alyson Parris, Amy Reynolds, Anastasia Sobolewski, Andrea Münsterberg, Barker, Belshaw, Carmon, Chen, Christopher Speakman, Christy Kam, Crawford Jamieson, de Lau, Esther Mitchell, Farin, Farrall, Freeman, Furukawa, Haramis, Hardwick, He, Howe, Howe, James Hernon, Jung, Kaur, Kevin Sargen, Kosinski, Kuhnert, Leedham, Lindqvist, Lopez-Garcia, Loren Bigwood, Mark R Williams, Medema, Michael Lewis, Miyoshi, Munoz, Naohide Oue, Natalia Wharton, Pinto, Playford, Reynolds, Richard Tighe, Richard Wharton, Sandeep Kapur, Sato, Sato, Sato, Scoville, Simmons, Snippert, Suzuki, van de Wetering, van der Flier, van der Flier, van Es, VanDussen, Wataru Yasui, William Stebbings, Yui, Zhao, Zhou, Ziskin   +63 more
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Krüppel-like factor 5 is essential for proliferation and survival of mouse intestinal epithelial stem cells

Stem Cell Research, 2015
Krüppel-like factor 5 (KLF5) is a pro-proliferative transcription factor that is expressed in dividing epithelial cells of the intestinal crypt. Leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) has been identified as a stem cell marker ...
Mandayam O. Nandan, Amr M. Ghaleb, Agnieszka B. Bialkowska, Vincent W. Yang   +3 more
doaj   +1 more source

Aging-related upregulation of the homeobox gene caudal represses intestinal stem cell differentiation in Drosophila.

PLoS Genetics, 2021
The differentiation efficiency of adult stem cells undergoes a significant decline in aged animals, which is closely related to the decline in organ function and age-associated diseases.
Kun Wu, Yiming Tang, Qiaoqiao Zhang, Zhangpeng Zhuo, Xiao Sheng, Jingping Huang, Jie'er Ye, Xiaorong Li, Zhiming Liu, Haiyang Chen   +9 more
doaj   +1 more source