Results 61 to 70 of about 1,734,969 (325)

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Surgeon\u27s perspective on short bowel syndrome: Where are we? [PDF]

, 2018
Short bowel syndrome (SBS) is due to a massive loss of small bowel: the reduction of gut function is below the minimum necessary to maintain health (in adults) and growth (in children) so intravenous supplementation is required.
Lauro, Augusto, Marino, Ignazio R.
core   +1 more source

p-Cresyl sulfate [PDF]

, 2017
If chronic kidney disease (CKD) is associated with an impairment of kidney function, several uremic solutes are retained. Some of these exert toxic effects, which are called uremic toxins.
Glorieux, Griet, Gryp, Tessa, Vaneechoutte, Mario, Vanholder, Raymond   +3 more
core   +3 more sources

Preferences for post‐traumatic osteoarthritis prevention strategies in individuals with anterior cruciate ligament injury

Arthritis Care &Research, Accepted Article.
Objectives There is growing interest in evaluating new strategies to delay or prevent post‐traumatic osteoarthritis (PTOA) in individuals who have sustained anterior cruciate ligament (ACL) injury. This study sought to determine characteristics of potential treatments that are acceptable to patients with ACL injury.
Kevin Kennedy, Lily Waddell, Adam Easterbrook, Jeffrey N. Katz, Cale Jacobs, Morgan Jones, Faith Selzer, Elena Losina, Liana Fraenkel, Nick Bansback   +9 more
wiley   +1 more source

Multivisceral Transplantation as curative Treatment for patients with Diffuse Splanchnic Arterial Ischemia: a case report

Intestinal Failure
Background: Criteria for multivisceral transplantation (MVTx) have broadened. However, diffuse splanchnic arterial ischemia secondary to visceral arterial thrombosis has only been described once.
Caroline Boelhouwer, Aksharaa Iyer, Antoine Dubois, Lawrence Bonne, Geert Maleux, Inge Fourneau, Sabrina Houthoofd, Albert Wolthuis, Philippe Nafteux, Hans Van Veer, Mauricio Sainz, Diethard Monbaliu, Lucas Wauters, Tim Vanuytsel, Laurens J. Ceulemans, Jacques Pirenne   +15 more
doaj   +1 more source

Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Belimumab in Pediatric Patients With Systemic Lupus Erythematosus: A Multicenter, Open‐Label Trial

Arthritis Care &Research, EarlyView.
Objective This study aimed to characterize the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of subcutaneous belimumab in pediatric patients with active systemic lupus erythematosus (SLE) receiving standard therapy. Methods This single‐arm, multicenter, open‐label trial (GSK study 200908; ClinicalTrials.gov identifier ...
Hermine I. Brunner, Jordi Antón, Inmaculada Calvo‐Penadés, Richard Dimelow, Gerd Horneff, Sylvia Kamphuis, Rebecca Marino, Andre van Maurik, Kirsten Minden, Masaaki Mori, Josephine Ocran‐Appiah, Christel Wilkinson, Yuichi Yamasaki, Deepak Assudani, for the Pediatric Rheumatology Collaborative Study Group (PRCSG) and Paediatric Rheumatology International Trials Organisation (PRINTO) Network investigators   +14 more
wiley   +1 more source

Neurodevelopmental, cognitive and motor function: Practice recommendations in pediatric intestinal failure and transplantation- position statement of the International Intestinal Rehabilitation and Transplant Association allied health committee

Intestinal Failure
Background: The objective of this position statement was to provide evidence-based and expert-informed recommendations for the assessment and treatment of neurodevelopment in children with intestinal failure and those undergoing intestinal transplant ...
Stephanie So, Catherine Patterson, Taru Palsa, Jemma Mears, Bianca C. Bondi, Sydney Dempster, Christina Belza   +6 more
doaj   +1 more source

Pancreatic transplantation at the University of Pittsburgh. [PDF]

, 2004
Campath-1H preconditioning with tacrolimus monotherapy is an effective immunosuppressive regimen for pancreas transplantation, with acceptable patient and graft survival rates early after transplantation.
Abu-Elmagd, K, Basu, A, Bond, G, Khan, A, Marcos, A, Mazariegos, G, Reyes, J, Shapiro, R, Sindhi, R, Starzl, TE, Tan, HP, Thai, NL, Tom, K   +12 more
core  

Intestinal neuromuscular function after preservation and transplantation [PDF]

, 1996
While it is well known that prolonged preservation of the intestinal graft causes severe mucosal damage after transplantation, little is known about the effect on neuromuscular function.
Hamada, N, Hutson, WR, Ikoma, A, Nakada, K, Starzl, TE, Suzuki, T, Todo, S, Zhu, Y   +7 more
core   +1 more source