Results 101 to 110 of about 98,760 (293)

Intestinal transplantation from the clinic to translational research [PDF]

, 2015
Uno de los mayores avances de la gastroenterología y la ci­rugía de los últimos 50 años ha sido el poder trasplantar los distintos órganos del aparato digestivo abdominal por separa­do o en su conjunto. La complejidad del trasplante intestinal llevó a la
Echevarria, Constanza, Gondolesi, Gabriel Eduardo, Pucci Molineris, Melisa Eliana, Martínez, María Inés, Meier, Dominik, Nachman, Fabio, Ramisch, Diego, Barros Schelotto, Pablo, Cabanne, Ana, Rumbo, Martín, Solar, Héctor, Rumbo, Carolina   +11 more
core  

A 3D In Vitro Model of the Human Hepatobiliary Junction

Advanced Science, EarlyView.
A 3D human organoid platform reconstructs the hepatobiliary junction between primary adult hepatocytes and intrahepatic cholangiocytes. These adult hepatobiliary organoids (aHBOs) support directional bile transport from canaliculi to ductule‐like structures, enable quantitative imaging of junction dynamics, and reveal cell‐type‐specific vulnerabilities
Ashley D. Westerfield, Katarzyna A. Grzelak, Katie Katsuyama, Vardhman Kumar, Bess M. Miller, Joa Yun, Jesse Kirkpatrick, David Mankus, Margaret E. Bisher, Abigail K.R. Lytton‐Jean, Z. Gordon Jiang, David D. Lee, Christopher S. Chen, Sangeeta N. Bhatia   +13 more
wiley   +1 more source

Cost-effectiveness of intestinal transplantation for adult patients with intestinal failure: a simulation study

, 2015
Background: Home parenteral nutrition (HPN) and intestinal transplantation (ITx) are the 2 treatment options for irreversible intestinal failure (IF). Objective: This study simulated the disease course of irreversible IF and both of these treatments HPN ...
Haveman, Jan Willem, Gerard Dijkstra, Krabbe, Paul F. M.; id_orcid, Dijkstra, Gerard, Roskott, Anne Margot, Rings, Edmond H. H. M., Rutger J Ploeg, Edmond Hhm Rings, Mireille J Serlie, Dijkstra, Gerard; id_orcid, Groen, Henk; id_orcid, Jan Willem Haveman, Geert Wanten, Krabbe, Paul F. M., Wanten, Geert, Groen, Henk, Anne Margot Roskott, Paul Fm Krabbe, Serlie, Mireille J., Henk Groen, Ploeg, Rutger J.   +20 more
core   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Improvements in intestine transplantation

Seminars in Pediatric Surgery, 2018
Transplantation of the intestine in children has presented significant challenges even as it has become a standard to treat nutritional failure due to short gut syndrome. These challenges have been addressed in part by significant improvements in short and long-term care.
Neslihan, Celik, Kaitlin, Stanley, Jeff, Rudolph, Feras, Al-Issa, Beverly, Kosmach, Chethan, Ashokkumar, Qing, Sun, Renee, Brown-Bakewell, Dale, Zecca, Kyle, Soltys, Ajai, Khanna, Geoffrey, Bond, Armando, Ganoza, George, Mazariegos, Rakesh, Sindhi   +14 more
openaire   +2 more sources

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Extended pancreas donor program - the EXPAND study rationale and study protocol [PDF]

, 2013
BACKGROUND: Simultaneous pancreas kidney transplantation (SPK), pancreas transplantation alone (PTA) or pancreas transplantation after kidney (PAK) are the only curative treatment options for patients with type 1 (juvenile) diabetes mellitus with or ...
Bechstein, Wolf Otto, Carsten Dietz, Falk Rauchfuss, Holub, Ines, Peter Schenker, Heise, Michael, Volker Müller, Rauchfuss, Falk, Proneth, Andrea, Florian Zeman, Björn Nashan, Markus Guba, Banas, Bernhard, Stefan Thorban, Schemmer, Peter, Edward K Geissler, Stephan Kersting, Ströhlein, Michael A., Andreas A Schnitzbauer, Nashan, Björn, Jonas, Sven, Thomas Becker, Ines Holub, Johanna R Foerster, Andreas Pascher, Manekeller, Steffen, Viebahn, Richard, Müller, Volker, Thomas Vogel, Peter Schemmer, Bernhard Banas, Farkas, Stefan A., Andrea Proneth, Arbogast, Helmut, Schenker, Peter, Richard Viebahn, Thorban, Stefan, Jürgen Klempnauer, Silvio Nadalin, Axel O Rahmel, Vogel, Thomas, Becker, Thomas, Guba, Markus, Zeman, Florian, Kersting, Stephan, Michael Heise, Rahmel, Axel, Klempnauer, Jürgen, Schlitt, Hans J., Schnitzbauer, Andreas, Stefan A Farkas, Nadalin, Silvio, Sven Jonas, Steffen Manekeller, Helmut Arbogast, Hans J Schlitt, Dietz, Carsten, Michael A Ströhlein, Geissler, Edward K., Wolf O Bechstein, Foerster, Johanna R., Pascher, Andreas, Andrea Proneth   +62 more
core   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

Fat absorption after small intestinal transplantation in the rat

, 1997
Intestinal transplantation is now used for patients with severe malabsorption, however, little data exists quantifying the ability of the graft to absorb fat. This study tested the hypothesis that intestinal transplantation would not affect the lymphatic
Smith, L J, Martin, G R, Winkelaar, G B, Sigalet, D L   +3 more
core   +1 more source