Results 121 to 130 of about 98,760 (293)

Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem Cells

Advanced Science, EarlyView.
In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu, Wenhao Zhang, Yifan Zhang, Yu He, Yi Du, Yiding Zhao, Chunmeng Yao, Shengyi Sun, Xiaoyan Sheng, Qian Gao, Chao Tong, Ling Shuai   +11 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Natural history of intestinal failure, investigated through a network-based approach.

, 2003
OBJECTIVES: Intestinal failure (IF) is a condition whose treatment requires advanced knowledge and techniques and a multidisciplinary approach. Intestinal failure is the endpoint of many intestinal diseases and may result in full recovery, in life-long ...
DE MARCO G, FOR THE ITALIAN NATIONAL NETWORK FOR PEDIATRIC INTESTINAL FAILURE, GUARINO, ALFREDO   +2 more
core   +1 more source

Isolated liver transplantation in an infant with ultrashort gut

, 2006
Intestinal function in children with very short bowel syndrome and related intestinal failure may improve after isolated liver transplantation. An infant with an ultrashort gut, ileo-cecal valve, and whole colon received total parenteral nutrition from ...
Otte, Jean-Bernard, Lezo, A., Baldi, M, Salizzoni, M., Lezo, A, Santini, B, DE VILLE DE GOYET, JEAN, Gennari, F., 10th International Symposium on Small Bowel Transplantation, Salizzoni, M, Otte, J, Calvo, P., Gennari, F, de Ville de Goyet, J, de Goyet, J. de Ville, Barbera, C, Santini, B., Barbera, C., Calvo, P, Baldi, M.   +19 more
core   +1 more source

Enhancing Maturation of Human Neuromuscular Organoids via Electrical Stimulation

Advanced Science, EarlyView.
A framework for on‐demand and non‐invasive exposure of human neuromuscular organoids (NMOs) to electrical stimuli is established to promote their maturation. The robustness and effectiveness of different stimulation regimes are evaluated via thorough characterization of organoid tissue structure and contraction capacity. Chronic electrical stimulation,
Chrysanthi‐Maria Moysidou, Inês Afonso Martins, Ismail Amr El‐Shimy, Iacopo Bicci, Donatella Cea, Christina Bukas, Isra Mekki, Mara‐Camelia Rusu, Aylin Nebol, Ines Lahmann, Marie Piraud, Enrico Klotzsch, Mina Gouti   +12 more
wiley   +1 more source

Present state of intestinal transplantation in Japan. [PDF]

Pediatr Surg Int, 2023
Ueno T, Wada M, Ogawa E, Matsuura T, Yamada Y, Sakamoto S, Okuyama H.   +6 more
europepmc   +1 more source

Intestinal transplantation: current status

, 1999
Current Treatment Of Intestinal Failure Consists Of Long-Term Total Parenteral Nutrition, Which Is Associated With Major Complications Including Liver Failure And Catheter Problems. The Ultimate Solution Is Small Bowel Transplantation.
Tam, PKH, Guo, WH
core  

Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang, Baoshuai Liang, Liangmin Fu, Weiliang Deng, Yuyan Jiang, Weiping Xu, Jinwei Chen, Ya Zhou, Ke Wu, Jiaguo Huang   +9 more
wiley   +1 more source

Indications for intestinal and multivisceral transplantation in pediatric patients: a systematic review

Journal of Pediatric Surgery Open
Objective: This is a systematic review that aims to collect and analyze existing literature on the indications for intestinal transplantation and multivisceral transplantation in pediatric patients. Methodology: The electronic search method was developed
Vinícius Gutierres de Paula Silva, Cristina Teodoro de Melo Mendo, Stefania Pinto Mota   +2 more
doaj   +1 more source

Idiopathic Ileal Ulceration After Intestinal Transplantation. [PDF]

Transplant Direct, 2023
Hussan E, Kroemer A, Elsabbagh AM, Khan KM, Yazigi NA, Ekong UD, Subramanian S, Ghobrial SS, Guerra JF, Fishbein TM, Matsumoto CS, Kaufman SS.   +11 more
europepmc   +1 more source