Results 231 to 240 of about 640,590 (268)

Dietary pectin enhances intestinal antimicrobial protein expression via a tuft cell-ILC2-STAT6 signaling axis. [PDF]

Curr Res Food Sci
Yanagi C, Ishii Y, Ishikawa S, Inoue R, Rini DM, Suzuki T.   +5 more
europepmc   +1 more source

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

Route-Dependent Mucosal and Systemic Immune Remodeling Induced by a Regulated-Lysis <i>Edwardsiella piscicida</i> Vaccine in Channel Catfish. [PDF]

Vaccines (Basel)
Miryala KR, Curtiss R, Lima V, Swain B.
europepmc   +1 more source

Epithelial TRIM27 Inhibits Intestinal Inflammation in Ulcerative Colitis by the USP7/TRIM27‐IKK Double Negative‐Feedback

Advanced Science, EarlyView.
ABSTRACT The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF‐κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)‐induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF‐κB pathway and its
Weimin Xu, Zhebin Hua, Zhujiang Dai, Shasha Zhang, Yihan Jiang, Wensong Ge, YingWei Chen, Zhongchuan Wang, Bing Zhang, Chen‐Ying Liu, Peng Du   +10 more
wiley   +1 more source

Development and functional adaptation of intestinal macrophages across the lifespan. [PDF]

Clin Transl Immunology
Mustafa B, Hill-Yardin EL, Spencer SJ.
europepmc   +1 more source

A Chirality‐Converted Bacteriolytic Dodecapeptide Regulates Vibrio‐Induced Polymicrobial Infection and Ameliorates Invasion‐Associated Gut Microbiota Disequilibrium

Advanced Science, EarlyView.
Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng, Qipeng Cheng, Xiaoxu Zhang, Honglan Wang, Jinghan Zhang, Xinyi Ding, Pengfei Zhang, Lanhua Yi, Kwok‐Yin Wong, Kin‐Fai Chan, Sheng Chen, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

Endoscopic treatment of walled-off necrosis with fistulas to the small intestine and colon using a lumen-apposing metal stent. [PDF]

Endoscopy
Yagi S, Hasegawa S, Honda Y, Iizuka T, Kurita Y, Kubota K, Yoneda M.   +6 more
europepmc   +1 more source

Targeting METTL3 Attenuates Thyroid Inflammatory Injury by Restoring Th17/Treg Balance through a YTHDC2‐m6A‐Dependent KDR/VEGFA Loop

Advanced Science, EarlyView.
METTL3‐mediated m6A modification stabilizes KDR/Kdr mRNA through YTHDC2, amplifying the VEGFA‐KDR feedback loop and disturbing Th17/Treg balance. This pathway promotes persistent inflammation and tissue damage in patients with AIT, and inhibiting the METTL3‐KDR axis effectively disrupts this circuit, alleviating thyroid tissue injury and disease ...
Qingyi Hu, Huan Liu, Anwen Ren, Zimei Tang, Jie Tan, Wen Yang, Jie Ming, Tao Huang   +7 more
wiley   +1 more source

β-Hydroxybutyrate Improves Glucose Metabolism in Streptozotocin-Induced Type 1 Diabetes by Inhibiting Gut and Liver Glucose Transporters via GPR109A. [PDF]

Diabetes
Li S, Wang J, Xin C, Dong Y, Xie A, Song J, Wan J, Yin J.   +7 more
europepmc   +1 more source

Hybridization-Driven Herbivorous Adaptation in Fish: Morphological, Digestive, Transcriptome, and Microbial Evidence from a Hybrid of <i>Megalobrama amblycephala</i> (♀) × <i>Culter mongolicus</i> (♂). [PDF]

Int J Mol Sci
Li Y, Zhao C, Liu M, Luo C, Xiong Z, Chen H, Zhong H, Jiang J, Xin X, Wang Y, Zhang C, Wu C, Liu Q, Sun Y, Wang S, Wen M, Hu F, Liu S.   +17 more
europepmc   +1 more source