Results 151 to 160 of about 544,707 (268)

Sex and regional effects of <i>Bacteroides</i> in the gut. [PDF]

mBio
Valls RA, Barrack KE, Surve SV, Bliska JB, O'Toole GA.   +4 more
europepmc   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

Muribaculum as a microbial contributor of rifaximin-induced mucosal protection during chemotherapy. [PDF]

Gut Microbes
Correale C, Morandi M, Gil-Gomez A, Silvestri A, Gatti A, Braga D, Maroli A, Foppa C, De Zanet S, Algieri F, Lizier M, Rossetti R, Carloni S, Penna G, Spinelli A, Brescia P, Rescigno M.   +16 more
europepmc   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Toll-like receptor 2 impacts small intestinal villus capillarization through epithelial dual oxidase 2. [PDF]

Redox Biol
Paeslack N, Mimmler M, Schulz J, Kownatzki J, Kollar B, Melzow F, Zamor J, Dremova O, Kuntic M, Kiouptsi K, Soshnikova N, Mann A, Kittner JM, Daiber A, Sommer F, Reinhardt C.   +15 more
europepmc   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Epithelial chemokine CCL25 integrates T cell development and intestinal homeostasis. [PDF]

J Exp Med
Li J, Yang MT, Matsuda-Lennikov M, Kalle-Youngoue F, Ushio A, Kondo K, Gluckman M, Bando K, Abe T, Takada K, Kelly MC, Castro Martinez F, Chen Z, Wu C, Takahama Y.   +14 more
europepmc   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

A case of pneumothorax and subcutaneous emphysema caused by colonoscopy

Asian Journal of Surgery
Li-Long Wu, Yuan-Dan Zhuang, Ji-Hou Wang, Guang-Xiong Luo   +3 more
doaj   +1 more source

Myeloid Mir34a suppresses initiation and progression of intestinal and colitis-induced colon cancers in APC^min mice. [PDF]

Cell Death Dis
Chen Y, Liu F, König J, Bouznad N, Hermeking H.   +4 more
europepmc   +1 more source