Results 201 to 210 of about 544,707 (268)

Development and functional adaptation of intestinal macrophages across the lifespan. [PDF]

Clin Transl Immunology
Mustafa B, Hill-Yardin EL, Spencer SJ.
europepmc   +1 more source

Human‐Centered Innovation: Precision Nutrition and the Future of Food

Advanced Science, EarlyView.
ABSTRACT Nutritional science is moving beyond one‐size‐fits‐all recommendations toward more precise and personalized approaches, yet its implementation pathway remains unclear. This paper proposes a human‐centered precision nutrition framework that highlights the central roles of artificial intelligence (AI), food innovation, and human agency.
Shanshan Zhang, Yonggan Sun, Jiaqi Jiang, Shaoping Nie   +3 more
wiley   +1 more source

Route-Dependent Mucosal and Systemic Immune Remodeling Induced by a Regulated-Lysis <i>Edwardsiella piscicida</i> Vaccine in Channel Catfish. [PDF]

Vaccines (Basel)
Miryala KR, Curtiss R, Lima V, Swain B.
europepmc   +1 more source

Gut Microbiota, Immunity, and Metabolism in the Progression From Chronic Liver Disease to Hepatocellular Carcinoma

Advanced Science, EarlyView.
This review explains how chronic liver injury progresses toward hepatocellular carcinoma through interconnected changes in gut microbes, metabolism, immunity, fibrosis, and diet. It highlights microbial metabolites, bile‐acid signaling, immune dysfunction, and nutritional or microbiome‐based interventions as opportunities to identify risk earlier ...
Yi Hu, Caiyan Lin, Lijie Zhang, Xue Jiang, Huawen Li, Yangzhe Wu   +5 more
wiley   +1 more source

β-Hydroxybutyrate Improves Glucose Metabolism in Streptozotocin-Induced Type 1 Diabetes by Inhibiting Gut and Liver Glucose Transporters via GPR109A. [PDF]

Diabetes
Li S, Wang J, Xin C, Dong Y, Xie A, Song J, Wan J, Yin J.   +7 more
europepmc   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

Endoscopic treatment of walled-off necrosis with fistulas to the small intestine and colon using a lumen-apposing metal stent. [PDF]

Endoscopy
Yagi S, Hasegawa S, Honda Y, Iizuka T, Kurita Y, Kubota K, Yoneda M.   +6 more
europepmc   +1 more source

An Implantable Optogenetics‐Engineered Hydrogel for Amelioration of Rheumatoid Arthritis through Light‐Controlled Metabolic Reprogramming of Synovial Macrophages

Advanced Science, EarlyView.
An implantable hydrogel is designed to enable in situ and on‐demand secretion of GLP‐1 in synovium through blue light irradiation to activate GLP‐1R/HK2/VDAC1 pathway for upregulating tricarboxylic acid cycle and oxidative phosphorylation in macrophage, facilitating tissue repair and bone erosion recovery.
Dahai Hu, Yaru Sun, Qi Lu, Yi Zhang, Jieruo Li, Huige Hou, Huajun Wang, Hui Tang, Yunsong Zhang, Xiaofei Zheng, Qingsong Mei   +10 more
wiley   +1 more source

Hybridization-Driven Herbivorous Adaptation in Fish: Morphological, Digestive, Transcriptome, and Microbial Evidence from a Hybrid of <i>Megalobrama amblycephala</i> (♀) × <i>Culter mongolicus</i> (♂). [PDF]

Int J Mol Sci
Li Y, Zhao C, Liu M, Luo C, Xiong Z, Chen H, Zhong H, Jiang J, Xin X, Wang Y, Zhang C, Wu C, Liu Q, Sun Y, Wang S, Wen M, Hu F, Liu S.   +17 more
europepmc   +1 more source

Annotation of bat IG H/L/K loci and analysis of the characteristics of bat BCR-CDR3 repertoires. [PDF]

Front Immunol
Liu Q, Ma L, Li J, Liu L, Zhou H, Liu Z, Wang H, Yao X.   +7 more
europepmc   +1 more source