Results 101 to 110 of about 700,213 (303)

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Rectal endometriosis without typical gynecological symptoms mimics gastrointestinal stromal tumors: a case report and literature review

Frontiers in Oncology
Rectal endometriosis may be similar to gastrointestinal stromal tumors (GIST), especially in women without typical gynecological or cyclical gastrointestinal symptoms. A 45-year-old female patient had an eight-year history of rectal defecation difficulty
Xiaopeng Ma, Zhesen Tian, Zengfang Hao, Jiawei Cui, Guojian Zhang, Yalei Zhao   +5 more
doaj   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Identifying the location-dependent adipose tissue bacterial DNA signatures in obese patients that predict body weight loss

Gut Microbes
Recent sets of evidence have described profiles of 16S rDNA sequences in host tissues, notably in fat pads that are significantly overrepresented and can serve as signatures of metabolic disease. However, these recent and original observations need to be
Matthieu Minty, Alberic Germain, Jiuwen Sun, Gracia Kaglan, Florence Servant, Benjamin Lelouvier, Emiri Misselis, Radu Mircea Neagoe, Menghini Rossella, Marina Cardellini, Rémy Burcelin, Massimo Federici, José Manuel Fernandez-Real, Vincent Blasco-Baque   +13 more
doaj   +1 more source

Post-operative Management for Visceral (Intestine, Intestine/Liver, and Multi-Visceral) Transplantation

, 2016
Patients who require intestine-containing grafts may be categorized into three groups: (1) patients who need an isolated intestinal transplant for intestinal failure; (2) those who need both an intestine and liver transplant for intestinal failure with ...
Hiroshi Sogawa, Sogawa, Hiroshi
core   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Salivary microbiota signatures of periodontitis are associated with CGM-derived short-term glycaemic control in adults with type 1 diabetes: a pilot study

Frontiers in Endocrinology
AimsPeriodontitis is common in type 1 diabetes (T1D), yet its relationship with short-term glycaemic control remains unclear. Continuous glucose monitoring (CGM) provides complementary metrics to HbA1c, including Time in Range (TIR) and Time Above Range (
Kevin Munsch, Kevin Munsch, Kevin Munsch, Jiuwen Sun, Thibault Canceill, Thibault Canceill, Thibault Canceill, Paul Slisse, Charlotte Pegouret, Charlotte Pegouret, Swann Diemer, Pascale Loubières, Pascale Loubières, Sara Laurencin-Dalicieux, Sara Laurencin-Dalicieux, Sara Laurencin-Dalicieux, Matthieu Minty, Matthieu Minty, Matthieu Minty, Pierre Gourdy, Pierre Gourdy, Pierre Gourdy, Blandine Tramunt, Blandine Tramunt, Blandine Tramunt, Remy Burcelin, Vincent Blasco-Baque, Vincent Blasco-Baque, Vincent Blasco-Baque, Charlotte Thomas, Charlotte Thomas, Charlotte Thomas   +31 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source