Results 51 to 60 of about 685,570 (303)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Macrophages Inability to Mediate Adherent-Invasive E. coli Replication is Linked to Autophagy in Crohn’s Disease Patients

Cells, 2019
The macrophages from Crohn’s Disease (CD) patients are defective to control the replication of CD-associated adherent-invasive E. coli (AIEC). We aimed to identify the host factors associated with AIEC replication focusing on polymorphisms related ...
Anthony Buisson, Clara Douadi, Lemlih Ouchchane, Marion Goutte, Jean-Pierre Hugot, Anaëlle Dubois, Régine Minet-Quinard, Damien Bouvier, Gilles Bommelaer, Emilie Vazeille, Nicolas Barnich   +10 more
doaj   +1 more source

Gestational Weight Gain and Small for Gestational Age in Obese Women: A Systematic Review and Meta-Analysis

International Journal of Endocrinology, 2023
Objective. This systematic review and meta-analysis evaluates the relationship between gestational weight gain and the risk of small for gestational age in obese pregnant women. Methods.
Wen Chen, Beiyi Li, Kexin Gan, Jing Liu, Yajing Yang, Xiuqin Lv, Huijuan Ma   +6 more
doaj   +1 more source

A key role for E-cadherin in intestinal homeostasis and Paneth cell maturation. [PDF]

, 2010
E-cadherin is a major component of adherens junctions. Impaired expression of E-cadherin in the small intestine and colon has been linked to a disturbed intestinal homeostasis and barrier function.
Trülzsch, Konrad, Eckhard Wolf, Sylvia Steininger, Hirschi Benjamin, Müller-Höcker Josef, Frank T Kolligs, Allgäuer, Michael, Marlon R. Schneider, Schneider Marlon R., Dahlhoff, Maik, Gerhard Markus, Schneider, Marlon R., Konrad Trülzsch, Vogelmann, Roger, Maik Dahlhoff, Müller-Höcker, Josef, Michael Allgäuer, Allgäuer Michael, Horst David, Roger Vogelmann, Markus Gerhard, Horst, David, Frank T. Kolligs, Wolf Eckhard, Dahlhoff Maik, Benjamin Hirschi, Kolligs, Frank T., David Horst, Trülzsch Konrad, Wolf, Eckhard, Josef Müller-Höcker, Kolligs Frank T., Marlon R Schneider, Hirschi, Benjamin, Steininger Sylvia, Gerhard, Markus, Steininger, Sylvia, Vogelmann Roger   +37 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Dose-dependent effects of dietary fat on development of obesity in relation to intestinal differential gene expression in C57BL/6J mice [PDF]

, 2011
Excessive intake of dietary fat is known to be a contributing factor in the development of obesity. In this study, we determined the dose-dependent effects of dietary fat on the development of this metabolic condition with a focus on changes in gene ...
Boekschoten, Mark V., Bachmair, Eva-Maria, de Groot, Philip, Eva-Maria Bachmair, Isabel Rubio-Aliaga, Rubio-Aliaga Isabel, de Wit Nicole J. W., de Wit, Nicole J. W., Rubio-Aliaga, I., Nicole J. W. de Wit, Philip J. de Groot, Machmair, E.M., Boekschoten Mark V., Hooiveld, Guido, Wit, N.J.W., de, Philip J de Groot, de Groot Philip J., Boekschoten, M.V., Muller, M.R., Daniel Hannelore, Hooiveld, Guido J. E. J., Rubio-Aliaga, Isabel, Müller, Michael, Nicole J W de Wit, Guido J E J Hooiveld, Hannelore Daniel, Müller Michael, Daniel, H., Mark V Boekschoten, Michael Müller, Hooiveld Guido J. E. J., de Groot, Philip J., Guido J. E. J. Hooiveld, Bachmair Eva-Maria, Boekschoten, Mark, Daniel, Hannelore, Groot, P.J., de, de Wit, Nicole, Mark V. Boekschoten, Hannelore, Daniel, Hooiveld, G.J.E.J., de Groot, P.J., de Wit, Nicole J. W.;Boekschoten, Mark V.;Bachmair, Eva-Maria;Hooiveld, Guido J. E. J.;de Groot, Philip J.;Rubio-Aliaga, Isabel;Daniel, Hannelore;Müller, Michael, de Wit, N.J.W.   +43 more
core   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Regulation of bicarbonate secretion in marine fish intestine by the calcium-sensing receptor [PDF]

, 2018
In marine fish, high epithelial intestinal HCO3- secretion generates luminal carbonate precipitates of divalent cations that play a key role in water and ion homeostasis.
Gregorio, Silvia, Sílvia F. Gregório, Fuentes, Juan, Sílvia Gregório, Juan Fuentes   +4 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source