Results 61 to 70 of about 595,091 (292)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
BEGINNING TO UNDERSTAND THE ECONOMIC COSTS OF CHILDREN’S EXPOSURE TO INTIMATE PARTNER VIOLENCE
International Journal of Child, Youth & Family Studies, 2014 Intimate partner violence comprises 37% of violent crime in Canada, imposing significant economic costs on society. Childhood exposure to intimate partner violence is a well-documented phenomenon, but the resulting costs are less understood.
Martin A Andresen, Shannon J Linning
doaj +1 more source
Masculinities and men’s emotions in and after intimate partner relationships
, 2023 Men's emotions in intimate partner relationships have received little research attention. The current interpretive descriptive study included 30 Canadian-based men to address the research question, what are the connections between masculinities and men’s
Oliffe, J. +5 more
core +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
BMC Public HealthIntroduction Intimate partner violence is a human rights violation that often involves violence against women, which appears to be the most prevalent type of abuse.
Mamaru Melkam +7 more
doaj +1 more source
Effect of physical intimate partner violence on body mass index in low-income adult women
Cadernos de Saúde Pública, 2015 This study aimed to assess whether physical intimate partner violence affects the nutritional status of adult women with different levels of body mass index (BMI).
Marcela de Freitas Ferreira +5 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Roles of Alcohol in Intimate Partner Abuse
, 2014 There is little available evidence relating to the measurement of alcohol use in IPV relationships (McMurran & Gilchrist, 2008). This mixed-method, multi-phase project aimed to unpick some of the complicated roles that alcohol appears to have in intimate
Laxton, T. +5 more
core +6 more sources
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Health Research Policy and Systems, 2018 Background Integrating sustainable responses to intimate partner violence in health care is a persistent and complex problem internationally. New Zealand holds a leading role, having established national health system infrastructure for responding to ...
Claire Gear +2 more
doaj +1 more source