Results 91 to 100 of about 1,449,476 (289)

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

Theorising masculinity and intimate partner violence

, 2021
This chapter discusses different historical and contemporary approaches to men, masculinity and intimate partner violence. We present radical feminism and its analysis of men’s violence as an effect of patriarchal society, as well as a contribution to ...
Gottzén, Lucas,, Berggren, Kalle,, Bornäs, Hanna,   +2 more
core   +1 more source

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

Intimate partner violence during pregnancy and risks of low birth weight and preterm birth in hospitals of Tigray, Northern Ethiopia

Scientific Reports
Intimate partner Violence (IPV) can affect any woman, irrespective of their economic status, religion, or culture. This is a human-rights issue and due to its prevalence and adverse effects on pregnancy and birth, it must be given greater attention ...
Kahsay Zenebe Gebreslasie, Solomon Weldemariam, Gelawdyos Gebre, Dawit Zenebe, Mihreteab Mehari, Aklil Birhane, Rebecca Susan Dewey   +6 more
doaj   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Financial inclusion and intimate partner violence: What does the evidence suggest?

PLoS ONE, 2019
Financial inclusion is an area of growing global interest in women's empowerment policy and programming. While increased economic autonomy may be expected to reduce the prevalence of intimate partner violence, the mechanisms and contexts through which ...
Lotus McDougal, Jeni Klugman, Nabamallika Dehingia, Amruta Trivedi, Anita Raj   +4 more
doaj   +1 more source

A social empowerment intervention to prevent intimate partner violence against women in a microfinance scheme in Tanzania: findings from the MAISHA cluster randomised controlled trial

The Lancet Global Health, 2019
Summary: Background: Globally, about 30% of women have experienced physical or sexual violence, or both, from an intimate partner during their lifetime.
Saidi Kapiga, ProfMD, Sheila Harvey, PhD, Gerry Mshana, PhD, Christian Holm Hansen, PhD, Grace J Mtolela, Flora Madaha, BA, Ramadhan Hashim, PGD, Imma Kapinga, BA, Neema Mosha, MSc, Tanya Abramsky, MSc, Shelley Lees, PhD, Charlotte Watts, ProfPhD   +11 more
doaj   +1 more source

Intimate Partner Violence in Chinese Societies

, 2011
The Chinese are the largest ethnic group in the world. In the United States, Chinese Americans are the largest Asian-American group, constituting about 22.6% of the Asian-American population (Uba, 1994). Although the number of studies on intimate partner
Chan, EKL
core  

Interleukin‐39 is a Prognostic Biomarker and Therapy Target for Sepsis

Advanced Science, EarlyView.
Sepsis triggers a significant increase in IL‐39 production, with circulating levels markedly elevated and positively correlated with disease severity and poor clinical prognosis in sepsis patients. Mechanistically, macrophage‐derived IL‐39 activates the GP130 signaling pathway via a ligand‐receptor interaction, thereby fueling the pro‐inflammatory ...
Feng‐zhi Zhang, Hai‐jun Liu, Yan Yue, Jun‐jie Gao, Jin Zhang, Wen‐wu Zhang, Yun‐long Zhang, Wei‐hua Lu, Sheng‐wei Jin, Pu‐hong Zhang   +9 more
wiley   +1 more source

Spatial variation of intimate partner violence and its public health implication: a cross-sectional study

BMC Public Health
Background/Aim Intimate partner violence has a significant impact on people as individuals, as families, and as communities. The ripple effects extend beyond the immediate victims, straining healthcare systems, stifling economic productivity, and ...
Abisola Esther Babatope, Demilade Olusola Ibirongbe, Idowu Peter Adewumi, Damola Olanipekun Ajisafe, Oluwafunbi Ajoke Fadipe, Gbenga Omotade Popoola, Kayode Olayiwola Adepoju, Oluyemi Adewole Okunlola   +7 more
doaj   +1 more source