Results 91 to 100 of about 1,267,955 (284)

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source

Intimate partner violence during pregnancy and risks of low birth weight and preterm birth in hospitals of Tigray, Northern Ethiopia

Scientific Reports
Intimate partner Violence (IPV) can affect any woman, irrespective of their economic status, religion, or culture. This is a human-rights issue and due to its prevalence and adverse effects on pregnancy and birth, it must be given greater attention ...
Kahsay Zenebe Gebreslasie, Solomon Weldemariam, Gelawdyos Gebre, Dawit Zenebe, Mihreteab Mehari, Aklil Birhane, Rebecca Susan Dewey   +6 more
doaj   +1 more source

Intimate Partner Violence in Chinese Societies

, 2011
The Chinese are the largest ethnic group in the world. In the United States, Chinese Americans are the largest Asian-American group, constituting about 22.6% of the Asian-American population (Uba, 1994). Although the number of studies on intimate partner
Chan, EKL
core  

Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery

Advanced Science, EarlyView.
Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae, Jisun Lee, Jae‐Hun Ahn, Hosam Choi, Huijeong Choi, Jungmin Kim, Minho Kang, Ho Rim Oh, So Hyun Park, Eun Young Oh, Sanghyuk Jeon, Yeeun Lee, Yu‐Sun Lee, Na‐Young Lee, Hee‐Jin Bae, Jina Kwak, Jooil Kim, Nakyung Lee, Beomsun Kang, Ji‐Hye Kim, Eunsaem Song, Daesub Song, Hyunho Yoon, Sang‐Myeong Lee, Hyewon Youn, Kiyoun Lee, Byeong‐Cheol Kang, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Financial inclusion and intimate partner violence: What does the evidence suggest?

PLoS ONE, 2019
Financial inclusion is an area of growing global interest in women's empowerment policy and programming. While increased economic autonomy may be expected to reduce the prevalence of intimate partner violence, the mechanisms and contexts through which ...
Lotus McDougal, Jeni Klugman, Nabamallika Dehingia, Amruta Trivedi, Anita Raj   +4 more
doaj   +1 more source

A social empowerment intervention to prevent intimate partner violence against women in a microfinance scheme in Tanzania: findings from the MAISHA cluster randomised controlled trial

The Lancet Global Health, 2019
Summary: Background: Globally, about 30% of women have experienced physical or sexual violence, or both, from an intimate partner during their lifetime.
Saidi Kapiga, ProfMD, Sheila Harvey, PhD, Gerry Mshana, PhD, Christian Holm Hansen, PhD, Grace J Mtolela, Flora Madaha, BA, Ramadhan Hashim, PGD, Imma Kapinga, BA, Neema Mosha, MSc, Tanya Abramsky, MSc, Shelley Lees, PhD, Charlotte Watts, ProfPhD   +11 more
doaj   +1 more source

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

Spatial variation of intimate partner violence and its public health implication: a cross-sectional study

BMC Public Health
Background/Aim Intimate partner violence has a significant impact on people as individuals, as families, and as communities. The ripple effects extend beyond the immediate victims, straining healthcare systems, stifling economic productivity, and ...
Abisola Esther Babatope, Demilade Olusola Ibirongbe, Idowu Peter Adewumi, Damola Olanipekun Ajisafe, Oluwafunbi Ajoke Fadipe, Gbenga Omotade Popoola, Kayode Olayiwola Adepoju, Oluyemi Adewole Okunlola   +7 more
doaj   +1 more source

TPI1 Loss Triggers a Metabolite‐Driven Mitochondrial Redox Vulnerability via the SARM1–cADPR–Ca2+ Axis

Advanced Science, EarlyView.
Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Chunyu Liu, Shun Wu, Chuang Wang, Zirui Zhou, Tianwei Cai, Wen Tao, Shidong Zuo, Chi Zhang, Yuhao Dong, Yi Feng, Qingbo Huang, Baojun Wang, Xin Ma, Haoli Ma, Xu Zhang, Yan Huang   +15 more
wiley   +1 more source