Results 101 to 110 of about 59,439 (303)

AI‐Assisted Digital Single‐Molecule Activity Tracker for Decoupling Intrinsic Heterogeneity from Photo‐Oxidative Damage in High‐Photon‐Flux Enzymology

Advanced Science, EarlyView.
Employing a digital single‐molecule activity tracker (dSMAT), this research demonstrates that high‐photon‐flux irradiation drives progressive oxidative scarring in polymerases. Unlike simple thermal denaturation, real‐time kinetic tracking dynamically visualizes enzymes degrading into multiple impaired subpopulations.
Anran Zheng, Qi Yang, Jinze Li, Fuqiang Ma, Xuefeng Wang, Zhen Guo, Chuanyu Li, Dongshu Li, Jia Yao, Zhiqi Zhang, Wei Zhang, Lianqun Zhou   +11 more
wiley   +1 more source

Family violence across the life cycle [PDF]

, 2014
Aims to address clinical questions that general practitioners (GPs) may have in identifying and responding to patients experiencing family violence. Background Family violence covers a range of abuse including child abuse and neglect, intimate partner ...
Kelsey Hegarty, Laura Tarzia, Kirsty Forsdike, Elizabeth Hindmarsh   +3 more
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RBM12 Maintains Glioma Stem Cells by Activating Amino Acid‐Dependent mTORC1 Signaling via SLC7A5 mRNA Stabilization

Advanced Science, EarlyView.
This study shows that in glioma stem cells (GSCs), RBM12 recruits ALKBH5 to remove m6A from SLC7A5 transcripts, thereby enhancing mRNA stability, which elevates large neutral amino acid (LNAA) levels and activates mTORC1, promoting GSC proliferation, self‐renewal, and tumor growth.
Hong Lei, Wenlong Luo, Shu Zhou, Lihao Wan, Peng Ling, Zhihua Huang, Zhihua Qian, Chenfei Lu, Mengyue Guo, Zhen Xue, Jun Qin, Ningwei Zhao, Jianghong Man, Wenchao Zhou, Zhiqiang Dong, Shutong Xu, Zhipeng Zhou, Xiuxing Wang, Weiwei Tao   +18 more
wiley   +1 more source

Primary care identification and referral to improve safety of women experiencing domestic violence (IRIS): protocol for a pragmatic cluster randomised controlled trial. [PDF]

, 2010
BACKGROUND: Domestic violence, which may be psychological, physical, sexual, financial or emotional, is a major public health problem due to the long-term health consequences for women who have experienced it and for their children who witness it.
Danielle Dunne, Dunne, D, Jean Ramsay, Medina Johnson, Rutterford, Clare, Sharp, Debbie, Sharp, D, Baird, K, Eldridge, Sandra, Feder, G, Rutterford, C, Angela Devine, Baird, Kathleen, Annie Howell, Ramsay, Jean, Ramsay, J, Howell, A, Eldridge, S, Roxane Agnew-Davies, Devine, Angela, Clare Rutterford, Alison Gregory, Dunne, Danielle, Johnson, M, Rutterford, Claire, Agnew-Davies, Roxane, Johnson, Medina, Gregory, AC, Howell, Annie, Feder, Gene, Devine, A, Debbie Sharp, Agnew-Davies, R, Gregory, Alison, Agnew Davies, R, Kathleen Baird, Gregory, A, Sandra Eldridge, Gene Feder   +38 more
core   +1 more source

Intimate partner violence during pregnancy and risks of low birth weight and preterm birth in hospitals of Tigray, Northern Ethiopia

Scientific Reports
Intimate partner Violence (IPV) can affect any woman, irrespective of their economic status, religion, or culture. This is a human-rights issue and due to its prevalence and adverse effects on pregnancy and birth, it must be given greater attention ...
Kahsay Zenebe Gebreslasie, Solomon Weldemariam, Gelawdyos Gebre, Dawit Zenebe, Mihreteab Mehari, Aklil Birhane, Rebecca Susan Dewey   +6 more
doaj   +1 more source

A social empowerment intervention to prevent intimate partner violence against women in a microfinance scheme in Tanzania: findings from the MAISHA cluster randomised controlled trial

The Lancet Global Health, 2019
Summary: Background: Globally, about 30% of women have experienced physical or sexual violence, or both, from an intimate partner during their lifetime.
Saidi Kapiga, ProfMD, Sheila Harvey, PhD, Gerry Mshana, PhD, Christian Holm Hansen, PhD, Grace J Mtolela, Flora Madaha, BA, Ramadhan Hashim, PGD, Imma Kapinga, BA, Neema Mosha, MSc, Tanya Abramsky, MSc, Shelley Lees, PhD, Charlotte Watts, ProfPhD   +11 more
doaj   +1 more source

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, EarlyView.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source

Financial inclusion and intimate partner violence: What does the evidence suggest?

PLoS ONE, 2019
Financial inclusion is an area of growing global interest in women's empowerment policy and programming. While increased economic autonomy may be expected to reduce the prevalence of intimate partner violence, the mechanisms and contexts through which ...
Lotus McDougal, Jeni Klugman, Nabamallika Dehingia, Amruta Trivedi, Anita Raj   +4 more
doaj   +1 more source

Metagenomic Association Uncovers Host Genotype‐Structured Rhizobacterial Networks and Novel Taxa That Enhance Soybean Salt Tolerance

Advanced Science, EarlyView.
An STI‐guided metagenomic association framework links soybean salt‐tolerance phenotypes with rhizosphere microbiome composition and network organization in natural saline soils. The approach identifies candidate beneficial taxa, including Thalassospira xiamenensis, and provides an efficient strategy for mining stress‐protective microbes from native ...
Yu Luo, Feng‐Li Kang, Qi‐Min Li, Wei‐Cai Yang   +3 more
wiley   +1 more source

Charming or harming: Case studies of emotional abuse in heterosexual intimate partner relationships [PDF]

, 2013
Emotional abuse in the absence of physical abuse is often unrecognised. Although the literature identifies the insidious nature of this type of abuse and the physiological, psychological and emotional harm it often causes, knowledge of how women come to ...
Corbett, Catherine
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