Results 131 to 140 of about 58,680 (271)

Beyond Docking: A Multi‐Tier Computational Pipeline for USP7 Inhibitor Optimization

open access: yesChemMedChem, Accepted Article.
Ubiquitin‐specific protease 7 (USP7) is a key deubiquitinating enzyme involved in tumor suppression, DNA repair, and epigenetic regulation. Given its critical role in cancer progression, USP7 has emerged as an attractive therapeutic target. In this study, we employed a multi‐tier computational approach, integrating ligand‐based virtual screening ...
Serdar Durdagi   +3 more
wiley   +1 more source

A social empowerment intervention to prevent intimate partner violence against women in a microfinance scheme in Tanzania: findings from the MAISHA cluster randomised controlled trial

open access: yesThe Lancet Global Health, 2019
Summary: Background: Globally, about 30% of women have experienced physical or sexual violence, or both, from an intimate partner during their lifetime.
Saidi Kapiga, ProfMD   +11 more
doaj  

‘Acceptance of diversity’…but not too much? (Restricted) pathways towards transgender and intersex inclusivity in sex education curriculum guidelines

open access: yesThe Curriculum Journal, EarlyView.
Abstract Positive representation of LGBTQIA+ perspectives in curriculum can help improve well‐being of transgender and intersex students. However, research on sex education curriculum indicates that the experiences of intersex and transgender students are largely absent in the respective curriculum or constructed as other, pathologized or stigmatized ...
Ayla Fedorchenko
wiley   +1 more source

Geological and geotechnical challenges on the Great Dyke of Zimbabwe and their impact on hardrock pillar design

open access: yesDeep Underground Science and Engineering, EarlyView.
The Great Dyke of Zimbabwe is notable for its rich platinum group metal deposits but poses significant geological and geotechnical challenges due to its complex rock types and structural features. Traditional pillar design methods are insufficient for addressing these complexities; the study suggests incorporating advanced techniques such as machine ...
Tawanda Zvarivadza   +3 more
wiley   +1 more source

An analysis of contractile and protrusive cell behaviors at the superficial surface of the zebrafish neural plate

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background The forces underlying convergence and internalization of the teleost neural plate remain unknown. To help understand this morphogenesis, we analyzed collective and individual cell behaviors at the superficial surface of the neural plate as internalization begins to form the neural keel in the hindbrain region of the zebrafish embryo.
Claudio Araya   +11 more
wiley   +1 more source

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