Results 31 to 40 of about 2,312,449 (162)

Separating the signal from the noise in metagenomic cell-free DNA sequencing

Microbiome, 2020
Background Cell-free DNA (cfDNA) in blood, urine, and other biofluids provides a unique window into human health. A proportion of cfDNA is derived from bacteria and viruses, creating opportunities for the diagnosis of infection via metagenomic sequencing.
Philip Burnham, Nardhy Gomez-Lopez, Michael Heyang, Alexandre Pellan Cheng, Joan Sesing Lenz, Darshana M. Dadhania, John Richard Lee, Manikkam Suthanthiran, Roberto Romero, Iwijn De Vlaminck   +9 more
doaj   +1 more source

Intra-Amniotic Inflammation or Infection: Suspected and Confirmed Diagnosis of “Triple I” at Term

Children, 2023
Chorioamnionitis (CA) at term of pregnancy can have an infectious and/or inflammatory origin and is associated with adverse outcomes. Triple I (intrauterine inflammation, infection, or both, TI) has been proposed to reduce the overdiagnosis of infection ...
Sara Consonni, Elettra Salmoiraghi, Isadora Vaglio Tessitore, Armando Pintucci, Valentina Vitale, Patrizia Calzi, Francesca Moltrasio, Anna Locatelli   +7 more
doaj   +1 more source

Intra-amniotic Candida albicans infection induces mucosal injury and inflammation in the ovine fetal intestine [PDF]

, 2016
Chorioamnionitis is caused by intrauterine infection with microorganisms including Candida albicans (C. albicans). Chorioamnionitis is associated with postnatal intestinal pathologies including necrotizing enterocolitis.
Kallapur, Suhas G., Payne, Matthew S, Jacobs, Esmee MR, Kemp, Matthew W., Janssen, Leon EW, Newnham, John P., Saito, Masatoshi, Kallapur, Suhas G, Hornef, Mathias W, Janssen, Leon E W., Wolfs, Tim GAM, Jobe, Alan H, Janssen, Leon E. W., Kramer, Boris W, Jacobs, Esmee M. R., Payne, Matthew S., Wolfs, Tim G A M., Jacobs, Esmee M R., Jobe, Alan H., Hornef, Mathias W., Kemp, Matthew W, Newnham, John P, Nikiforou, Maria, Kramer, Boris W., Wolfs, Tim G. A. M.   +24 more
core   +1 more source

Intra-amniotic infection and sterile intra-amniotic inflammation in women with preterm labor with intact membranes are associated with a higher rate of Ureaplasma species DNA presence in the cervical fluid

, 2022
To determine the prevalence of Ureaplasma spp. DNA and its load in the cervical fluid in women with preterm labor with intact membranes (PTL) complicated by intra-amniotic infection (the presence of both microbial invasion of the amniotic cavity and ...
Kacerovsky, Marian, Stranik, Jaroslav, Bolehovska, Radka, Jacobsson, Bo,, Musilova, Ivana, Bostik, Pavel, Matulova, Jana, Stepan, Martin, Hladky, Jan, Kukla, Rudolf   +9 more
core   +1 more source

Noninvasive prediction models of intra-amniotic infection in women with preterm labor [PDF]

, 2022
Corrigendum published online July 9, 2025 at https://doi.org/10.1016/j.ajog.2025.06.045Among women with preterm labor, those with intraamniotic infection present the highest risk of early delivery and the most adverse outcomes.
Rueda, Claudia, Gratacós Solsona, Eduard, Sánchez García, Ana B., Cascante i Serratosa, Marta, Bosch Mestres, Jordi, Palacio, Montse, Marín Martínez, Silvia, Collado, Maria Carmen, Filella Pla, Xavier, Murillo Bravo, Clara, Ponce, Júlia, Cobo, Teresa, Ferrero Martínez, Silvia, Burgos Artizzu, Xavier P., Andreu Fernández, Vicente, Boada, David   +15 more
core   +2 more sources

Scatter plot of fold changes in protein abundance with intra- amniotic infection and with sterile intra-amniotic inflammation between pairs of amniotic fluid compartments.

, 2020
Proteins for which the changes were significantly different between compartments are highlighted in red. Data represents log2 fold changes between groups.
Gregory Edward Rice (8313273), Leonid Margolis (284647), Gaurav Bhatti (344747), Wendy Fitzgerald (8313276), Adi L. Tarca (6856166), Nardhy Gomez-Lopez (337881), Roberto Romero (19224), Mahendra Kavdia (319390), Percy Pacora (4268128)   +8 more
core   +1 more source

Volcano plot of—log₁₀ transformed p-values against log₂ transformed fold changes illustrating the changes in protein abundance with intra-amniotic infection and with sterile intra-amniotic inflammation.

, 2020
Differentially abundant proteins (q-value < 0.05) are highlighted in red. Changes in protein concentrations were most evident when comparing preterm labor with intra-amniotic infection to preterm labor without either intra-amniotic inflammation or proven
Gregory Edward Rice (8313273), Leonid Margolis (284647), Gaurav Bhatti (344747), Wendy Fitzgerald (8313276), Adi L. Tarca (6856166), Nardhy Gomez-Lopez (337881), Roberto Romero (19224), Mahendra Kavdia (319390), Percy Pacora (4268128)   +8 more
core   +1 more source

The Relationship between Intra-Amniotic Sludge and the Amniotic Fluid Proteome in a Cohort of Pregnant Women with Acute Cervical Insufficiency: A Pilot Study

Clinical and Experimental Obstetrics & Gynecology, 2023
Background: We aim to determine the relationship between intra-amniotic sludge and the amniotic fluid proteome in cases of acute cervical insufficiency.
Rachelle N. M. Govia, Kenzie D. Birse, Adam D. Burgener, Vanessa Poliquin, Savas M. Menticoglou, Christy L. Pylypjuk   +5 more
doaj   +1 more source

Proteomic profiling of the amniotic fluid to detect inflammation, infection, and neonatal sepsis. [PDF]

PLoS Medicine, 2007
Proteomic analysis of amniotic fluid shows the presence of biomarkers characteristic of intrauterine inflammation. We sought to validate prospectively the clinical utility of one such proteomic profile, the Mass Restricted (MR) score.We enrolled 169 ...
Catalin S Buhimschi, Vineet Bhandari, Benjamin D Hamar, Mert-Ozan Bahtiyar, Guomao Zhao, Anna K Sfakianaki, Christian M Pettker, Lissa Magloire, Edmund Funai, Errol R Norwitz, Michael Paidas, Joshua A Copel, Carl P Weiner, Charles J Lockwood, Irina A Buhimschi   +14 more
doaj   +1 more source

Evidence that antibiotic administration is effective in the treatment of a subset of patients with intra-amniotic infection/inflammation presenting with cervical insufficiency. [PDF]

Am J Obstet Gynecol, 2019
Background: Cervical insufficiency is a risk factor for spontaneous midtrimester abortion or early preterm birth. Intra-amniotic infection has been reported in 8-52% of such patients and intra-amniotic inflammation in 81%. Some professional organizations
Oh KJ, Romero R, Park JY, Lee J, Conde-Agudelo A, Hong JS, Yoon BH.   +6 more
europepmc   +2 more sources