Results 111 to 120 of about 6,871 (232)

Smart Nanodelivery Systems for Immunometabolic Modulation in Osteoarthritis

Exploration, EarlyView.
Smart nanodelivery systems deliver therapeutic payloads across the cartilage matrix to ensure their sustained accumulation within chondrocytes at sites of injury. By targeting specific molecular targets and signaling pathways, these platforms modulate the pathological synovium‐cartilage axis to restore immunometabolic homeostasis and drive tissue ...
Qirui Zhao, Zhewen Mi, Shuya Liu, Shijun Liang, Linjia Peng, Zixuan Gao, Jiaming Li, Xiaoqing Lu, Zhiguang Ren, Yongjie Wan, Shengsheng Cui, Longlong Lu, Xiaoyang Gao, Tao Wang, Hui Liang, Furong Tian, de la Fuente Jesus M, Chong Xiang, Luyi Sun, Lichen Xiang, Daxiang Cui   +20 more
wiley   +1 more source

Intra-Articular Injection of Alginate-Microencapsulated Adipose Tissue-Derived Mesenchymal Stem Cells for the Treatment of Osteoarthritis in Rabbits

Stem Cells International, 2018
We investigated the effects of intra-articular injections of alginate-microencapsulated adipose tissue-derived mesenchymal stem cells (ASCs) during osteoarthritis (OA) development in a rabbit model of anterior cruciate ligament transection (ACLT).
Seongjae Choi, Jun-Hyung Kim, Jeongho Ha, Bo-Ing Jeong, Yun Chan Jung, Geun-Shik Lee, Heung-Myong Woo, Byung-Jae Kang   +7 more
doaj   +1 more source

RecUrrent Intra-articular Corticosteroid injections in Osteoarthritis: the RUbICOn mixed-methods study

BackgroundIntra-articular corticosteroid injections are an adjunct to core treatments for osteoarthritis. The National Institute for Health and Care Research Health Technology Assessment programme commissioned this research to address uncertainty around ...
Donovan, Richard, Ashley W Blom, Blom, Ashley W, Wylde, Vikki, Jameson, Catherine, Samuel Hawley, Richard Donovan, Edith Anderson, Gulraj Matharu, Uribe, Albert Prats, Matharu, Gulraj, Moore, Andrew, Michael Richard Whitehouse, Catherine Jameson, Antonella Delmestri, Vikki Wylde, Cecily Palmer, Hawley, Samuel, Albert Prats Uribe, Prieto-Alhambra, Daniel, Whitehouse, Michael Richard, Daniel Prieto-Alhambra, Rachael Gooberman-Hill, Gooberman-Hill, Rachael, Delmestri, Antonella, Judge, Andrew, Anderson, Edith, Barker, Karen, Andrew Judge, Palmer, Cecily, Nick Snelling, Snelling, Nick, Andrew Moore, Karen Barker   +33 more
core   +1 more source

Sel1l preserves condylar cartilage matrix homeostasis by regulating PERK signaling

Interdisciplinary Medicine, EarlyView.
Our study revealed that the expression of Sel1l was downregulated in OA cartilage and that Sel1l deficiency induced cartilage catabolism. Mechanistically, Sel1l depletion aberrantly activated PERK signaling and resulted in ER stress. PERK inhibition rescued the phenotype of Sel1l‐deficient chondrocytes and alleviated TMJOA pathogenesis.
Xinqi Huang, Zinan Cen, Zhihe Zhao, Xiao Cen   +3 more
wiley   +1 more source

Intra-articular injection of steroid

, 1997
Intra-articular steroid injection is a useful technique to acquire for doctors in the field of rheumatology and orthopaedic surgery as well as family medicine.
Lee, GKW, Lau, CS
core  

Cervical Intra-Articular Facet Injection: Computed Tomography

, 2016
Intra-articular facet joint injections commonly refer to the injection of a contrast media and local anesthetic solution, with or without corticosteroids, directly into the facet joint space.
Allan L. Brook, Karina Gritsenko, Amaresh Vydyanathan, Samer N. Narouze   +3 more
core   +1 more source

USP7 Regulates TRPV1 Deubiquitination to Mediate Chondrocyte Ferroptosis and Alleviate Osteoarthritis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osteoarthritis (OA) is a common degenerative joint disease characterized by chondrocyte dysfunction. In this study, we explored the function and mechanism of ubiquitin‐specific protease 7 (USP7) in chondrocyte ferroptosis in OA. The USP7, TRPV1, collagen II, and GPX4 levels in knee joint tissue were detected using immunohistochemistry ...
Jun Li, Ding Chen, Wei‐Ye Zhong
wiley   +1 more source

Are intra-articular injections of hyaluronic acid effective for the treatment of temporomandibular disorders? A systematic review

, 2016
This systematic review aimed to investigate whether intra-articular injections of hyaluronic acid (HA) are better than other drugs used in temporomandibular joint arthrocentesis, for the improvement of temporomandibular disorder (TMD) symptoms.
Túrcio, K. H.L. [UNESP], de Medeiros, R. A. [UNESP], da Silva, E. V.F. [UNESP], dos Santos, D. M. [UNESP], Goiato, Marcelo Coelho [UNESP]   +4 more
core   +1 more source

A single intra‐articular stromal vascular fraction with platelet‐rich plasma injection yields superior clinical outcomes than a hyaluronic acid injection in patients with knee osteoarthritis: A prospective comparative study

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose The present study aimed to compare the efficacy and safety of a combined injection of stromal vascular fraction (SVF) and platelet rich plasma (PRP) versus a high molecular weight (HMW) hyaluronic acid (HA) injection in patients with knee osteoarthritis (KOA).
Trifon Totlis, Vlasios Achlatis, Panagiotis‐Konstantinos Emfietzis, Theodorakys Marín Fermín, Theodoros Pettas, Aristotelis Sideridis, Ioannis Terzidis   +6 more
wiley   +1 more source

Intra-Articular Injections of Polyphenols Protect Articular Cartilage from Inflammation-Induced Degradation: Suggesting a Potential Role in Cartilage Therapeutics.

, 2015
Arthritic diseases, such as osteoarthritis and rheumatoid arthritis, inflict an enormous health care burden on society. Osteoarthritis, a degenerative joint disease with high prevalence among older people, and rheumatoid arthritis, an autoimmune ...
Moti L. Tiku (749970), Balaraman Madhan, Venkatachalam Natarajan, Balaraman Madhan (749969), Moti L Tiku, Venkatachalam Natarajan (749968), Moti L. Tiku   +6 more
core   +1 more source