Repeated intra-articular injections of umbilical cord-derived mesenchymal stem cells for knee osteoarthritis: a phase I, single-arm study. [PDF]
Ao Y +7 more
europepmc +1 more source
Senescent synovial intimal fibroblasts (SIF) are identified as key drivers of osteoarthritis. They promote M1 macrophage polarization and cartilage degeneration via the ANGPTL4–α5β1 axis, regulated by transcription factors EGR1 and ATF3. Pharmacological inhibition of this pathway alleviates disease, revealing SIF senescence as a promising therapeutic ...
Muhai Deng +7 more
wiley +1 more source
The evolving efficacy landscape of intra-articular injections for rotator cuff injuries over time: a network meta-analysis of randomized controlled studies. [PDF]
Wu M, Yan C, Xu Y, Yan Z.
europepmc +1 more source
Outcomes from conservative treatment of shoulder idiopathic adhesive capsulitis and factors associated with developing contralateral disease [PDF]
Brophy, Robert H +2 more
core +1 more source
Spatial transcriptomics reveals a remodeled fibroblast‐immune microenvironment in the temporomandibular joint (TMJ) during arthritis. By combining seqFISH with genetic mouse models, this study uncovers TMJ spatial cell atalas, macrophage‐fibroblast crosstalk, and cytokine signaling pathways driving TMJ inflammation and pain.
Ziying Lin +10 more
wiley +1 more source
Efficacy of intra-articular injections for the treatment of osteoarthritis: A narrative review. [PDF]
Si-Hyeong Park S, Li B, Kim C.
europepmc +1 more source
Knee Osteoarthritis: Clinical and MRI Outcomes After Multiple Intra-Articular Injections With Expanded Autologous Adipose-Derived Stromal Cells or Platelet-Rich Plasma. [PDF]
Khoury MA +7 more
europepmc +1 more source
Multifocal pyomyositis after intra‐articular injections
Moriyama, Yuki, Nishioka, Hiroaki
openaire +2 more sources
Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo +5 more
wiley +1 more source
Placebo Effect Sizes in Clinical Trials of Knee Osteoarthritis Using Intra-Articular Injections of Biologic Agents. [PDF]
Borst JM +5 more
europepmc +1 more source

