Results 171 to 180 of about 6,871 (232)

Sarilumab in Polyarticular‐Course Juvenile Idiopathic Arthritis: Dose‐Finding and 1‐Year Analysis of a Phase 2b, Open‐Label, Multicenter Study

Arthritis Care &Research, Volume 78, Issue 6, Page 749-760, June 2026.
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension phase).
Fabrizio De Benedetti, Inmaculada C. Penadés, Irina Nikishina, Ivan Foeldvari, Alberto J. Spindler, Anna Kozlova, Nadina Rubio‐Pérez, Pierre Quartier, Zbigniew Żuber, Raul Barria, Daniel Clemente, Gabriel V. Cornejo, Katherine Marzan, Nancy Liu, Christine Xu, Stephen DiMartino, Angeliki Giannelou, Fei Cao‐Ghoul, Bolanle Akinlade, Lydie Baret‐Cormel   +19 more
wiley   +1 more source

Polyphenol‐Rich Duhuo Jisheng Decoction Enhances Mesenchymal Stem Cell–Derived Exosome–Mediated Chondroprotection via PI3K/AKT Signaling in Osteoarthritis

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
This graphical abstract illustrates the chondroprotective mechanism of exosomes derived from bone marrow mesenchymal stem cells (BMSCs) preconditioned with polyphenol‐rich Duhuo Jisheng Decoction (DHJST‐Exos). Enriched with bioactive compounds such as wogonin, quercetin, and kaempferol, DHJST‐Exos effectively ameliorate osteoarthritis (OA ...
Zhouwei Liao, Weiran Wang, Shunwan Jiang, Lixin Wang, Tian Yu, Xinqiang Ni, Shaoqun Zhang, Jun Liu, Junzheng Yang, Hui Xie   +9 more
wiley   +1 more source

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, Volume 2, Issue 2, June 2026.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source

Impact of Bone Grafting and Graft Type on Fusion and Patient‐Reported Outcomes Following Subtalar Arthrodesis: A Multicenter Retrospective Cohort Study

Journal of Foot and Ankle Research, Volume 19, Issue 2, June 2026.
ABSTRACT Background The role of bone grafting in subtalar joint arthrodesis (SJA) remains controversial. This study aimed to compare clinical and radiographic outcomes of SJA performed with and without bone graft and to evaluate the influence of different graft types on fusion and functional results.
Giovan Giuseppe Mazzella, Antonio Bove, Andrea De Fazio, Natale Maria Gangemi, Marco Peruzzi, Fabrizio Forconi, Philip Krekosch, Christian Lausmann, Mustafa Citak, Vincenzo Di Sanzo, Giulio Maccauro, Raffaele Vitiello   +11 more
wiley   +1 more source

Ultra High field MRI in patients with knee osteoarthritis receiving intra-articular injections of a hyaluronan derivative

Purpose: To prospectively evaluate morphologic and quantitative relaxometry changes of knee articular cartilage using UHF MRI in patients with symptomatic osteoarthritis of the knee within the first 6 months after receiving intra-articular injections of ...
BALDUCCI, FRANCESCO
core  

Synovial Fluid Biomarkers Reflect Pre‐ and Postoperative Clinical Features in Rotator Cuff Tears, Independent of Tear Size

Journal of Orthopaedic Research, Volume 44, Issue 6, June 2026.
ABSTRACT Synovitis is a major contributor to pain and dysfunction in rotator cuff tears (RCTs), yet it remains unclear whether routine synovial fluid (SF) parameters reflect clinical features independent of tear size, operation method, and patient age.
Seungmin Jeong, Jong Min Lee, Jeong‐Hyun Koh, Doohyung Lee   +3 more
wiley   +1 more source

Design and Development of a Wearable E‐Textile Garment for Knee Osteoarthritis Pain Management and Muscle Exercise

Small Structures, Volume 7, Issue 6, June 2026.
An e‐textile garment for knee osteoarthritis integrates transcutaneous electrical nerve stimulation electrodes targeting knee pain and neuromuscular electrical stimulation electrodes supporting thigh muscle exercise. Co‐designed with end users, the prototype undergoes evaluation for durability, usability, comfort, and pain relief, informing iterative ...
Gillian Lake‐Thompson, Meijing Liu, Elena Zaballa, Hongrui Zhang, Alison Wescott, Irfan Ullah, Tom Greig, Lynn Reeves, Dan Young, Elaine Dennison, John Tudor, Kai Yang   +11 more
wiley   +1 more source

Abnormal Stress Reduced miR‐330 Supplementation Alleviates Osteoarthritis Progression by Suppressing Osteochondral Catabolism

Aging Cell, Volume 25, Issue 6, June 2026.
Downregulation of miR‐330 under abnormal stress exacerbates catabolism in cartilage and subchondral bone, thereby promoting the progression of osteoarthritis. ABSTRACT Abnormal mechanical stress plays a crucial role in the progression of osteoarthritis (OA). Key factors regulating mechanical response remain to be explored. This study harvested synovium
Luxiang Zou, Kaiwen Yang, Chuyao Wang, Yeke Yu, Xiaoyu Zhang, Chuan Lu, Jieyun Zhao, An Qin, Dongmei He   +8 more
wiley   +1 more source

Comparison of cone beam CT and low‐field MRI for diagnosing equine foot and pastern lesions

Equine Veterinary Education, Volume 38, Issue 6, Page e332-e343, June 2026.
Summary Background While standing magnetic resonance imaging (sMRI) of the foot has been extensively studied, descriptions of cone beam computed tomography (CBCT) abnormalities in this region are sparse. Objective This study compares CBCT and sMRI for diagnosing lesions in the equine foot and pastern, aiming to assess the complementarity of these ...
M. Vandersmissen, C. E. Sherlock, A. J. Fairburn, T. S. Mair   +3 more
wiley   +1 more source

Ophthalmic Vascular Occlusion and Blindness After Platelet‐Rich Plasma Injections: A Systematic Review

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Background Platelet‐rich plasma (PRP) is widely used in aesthetic and regenerative medicine; however, rare vision‐threatening complications such as blindness have been reported following facial injections. Aims This systematic review aimed to identify and analyze all published cases of visual impairment following PRP injections.
Mandana Ebrahimzade, Shahriar Nazari, Mohammad Reza Pourani, Cristina Muñoz‐Gonzalez, Fahimeh Abdollahimajd, Maurizio Cavallini, Nabil Fakih‐Gomez   +6 more
wiley   +1 more source