Orthopaedic Surgery, EarlyView.This article outlines a paradigm shift in OA therapeutics, OA as a systemic disease of joint microenvironment imbalance. It synthesizes advances in targeting key pathological hubs—immune, metabolic, and senescent—and details novel regenerative strategies using engineered biomaterials and exosomes.
Yongbiao Meng, Shenghua Wu, Quanchun Liu
wiley +1 more source
The evolving efficacy landscape of intra-articular injections for rotator cuff injuries over time: a network meta-analysis of randomized controlled studies. [PDF]
J Orthop Surg ResWu M, Yan C, Xu Y, Yan Z.
europepmc +1 more source
Understanding exosomes in regenerative dentistry
Periodontology 2000, EarlyView.Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad +2 more
wiley +1 more source
Placebo Effect Sizes in Clinical Trials of Knee Osteoarthritis Using Intra-Articular Injections of Biologic Agents. [PDF]
Arthritis Care Res (Hoboken)Borst JM +5 more
europepmc +1 more source
Understanding extracellular vesicles in antiaging
Periodontology 2000, EarlyView.Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad +3 more
wiley +1 more source
Association of Physical Therapy Care With Use of Intra-Articular Injections in People With Knee Osteoarthritis: A Real-World Cohort Study. [PDF]
Arthritis RheumatolNeogi T +6 more
europepmc +1 more source
Clinically relevant intra‐articular corticosteroid doses impair equine osteoclast function in vitro
Veterinary Surgery, EarlyView.Abstract Objective To assess the effects of clinically relevant doses of commonly employed intra‐articular corticosteroids—specifically, triamcinolone acetonide (TCA), methylprednisolone acetate (MPA), and combination of betamethasone acetate and betamethasone sodium phosphate (BM)—on equine osteoclasts.
Gwladys Malek +4 more
wiley +1 more source
Veterinary Surgery, EarlyView.Abstract Objective To determine short‐ and long‐term outcomes of core decompression combined with autologous bone marrow aspirate concentrate (BMAC) in treating moderate‐to‐severe refractory distal sesamoid bone (DSB) trabecular pathology in horses. Study design Retrospective observational study. Animals A total of 21 client‐owned Warmblood horses with
Grigorios Maleas +2 more
wiley +1 more source
Multiple Intra-Articular Injections of Adipose-Derived Mesenchymal Stem Cells for Canine Osteoarthritis Treatment. [PDF]
CellsLi X, Jian X, Yan Z, Liu H, Zhang L.
europepmc +1 more source
Veterinary Surgery, EarlyView.Abstract Objective To determine whether reduced intra‐articular (IA) injection volumes provide complete synovial surface coverage while minimizing leakage following canine elbow arthroscopy. Study design Randomized cadaveric study. Animals Forty elbow joints from 20 canine cadavers weighing >15 kg.
Erin Smith +3 more
wiley +1 more source