Results 191 to 200 of about 833,273 (291)

Intra-articular Injections of Allogeneic Platelet-Rich Plasma from Responder Patients for the Treatment of Knee Osteoarthritis: A Pilot and Feasibility Clinical Trial. [PDF]

Cartilage
Sánchez M, Guadilla J, Jorquera C, Marijuán-Pinel D, Mercader-Ruiz J, Beitia M, Andrade R, Espregueira-Mendes J, González S, Oraa J, López de Dicastillo L, Fiz N, Azofra J, Delgado D.   +13 more
europepmc   +1 more source

Evasins: Biology and Therapeutic Potential of Broad‐Spectrum Chemokine Inhibitors

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
ABSTRACT Ticks are haematophagous parasites that rely on uninterrupted bloodmeals for survival and need an effective strategy to suppress the host inflammatory response. Leukocyte recruitment is a chemokine‐mediated hallmark of inflammation, which ticks counteract via anti‐chemokine proteins in their saliva named evasins.
Emilia L. Bialek, Roos Buds, Ingrid Dijkgraaf, Pedro E. Marques   +3 more
wiley   +1 more source

Efficacy of Platelet-Rich Plasma Intra-articular Injections in Hip and Knee Osteoarthritis. [PDF]

Cureus
Shahbaz A, Alzarooni A, Veeranagari VR, Patel K, Mohammed C, Kuruba V, Rajkumar N, Mirza BA, Rauf M, Maldonado Ramirez JG, Siddiqui HF.   +10 more
europepmc   +1 more source

Advances in the treatment of systemic lupus erythematosus: Biologicals, small‐molecular agents, and cell‐depleting therapies coming to the clinic

Journal of Internal Medicine, Volume 300, Issue 4, Page 461-479, October 2026.
Abstract Systemic lupus erythematosus (SLE; lupus) remains a particular challenge for the practicing clinician on account of its chronic undulating and unpredictable course, its diverse manifestations, and—until recently—limited treatment options all associated with considerable downsides.
Ronald van Vollenhoven
wiley   +1 more source

Dual intra-articular injections of corticosteroid and hyaluronic acid versus single corticosteroid injection for ankle osteoarthritis: a randomized comparative trial. [PDF]

BMC Musculoskelet Disord
Woo I, Park JJ, Park CH.
europepmc   +1 more source

Nucleic Acids as Emerging Regulators of Calcium Phosphate Biomineralization

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Calcium phosphate biomineralization has traditionally been considered a protein‐regulated process. This review highlights the emerging role of nucleic acids, which interact with mineral phases through adsorption, coprecipitation, and templating, thereby influencing crystal nucleation and growth.
Fanny Duhalde, Jessem Landoulsi, Xavier Houard   +2 more
wiley   +1 more source

Clinical Phenotypes, Treatment, and Outcomes of Rheumatic Immune–Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitors: A Rheumatologists‐Referred Multicenter German Registry Cohort

ACR Open Rheumatology, Volume 8, Issue 9, September 2026.
Objective Immune checkpoint inhibitors (ICIs) induce a broad range of immune‐related adverse events (irAEs), including rheumatic manifestations. Evidence from dedicated rheumatology cohorts on the clinical spectrum, severity, treatment, and outcomes of rheumatic irAEs (rh‐irAEs) remains limited.
Didzis Gailis, Fabian T.H. Ullrich, Sophia Dombret, Marc Schmalzing, Rebecca Hasseli‐Fräbel, Torsten Witte, Thea Thiele, Uta Kiltz, Mara Oleszowsky, Marcel Müller, Karolina Gente, Christof Specker, Matthias B. Thaler, Alla Skapenko, Hendrik Schulze‐Koops   +14 more
wiley   +1 more source

Factors affecting the therapeutic effects of multiple intra-articular injections of platelet-rich-plasma for knee osteoarthritis. [PDF]

Asia Pac J Sports Med Arthrosc Rehabil Technol
Kamada K, Matsushita T, Yamashita T, Matsumoto T, Iwaguro H, Kuroda R, Sobajima S.   +6 more
europepmc   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Associations of Longitudinal Multiparametric MRI Findings and Clinical Outcomes in Intra-Articular Injections for Knee Osteoarthritis. [PDF]

Diagnostics (Basel)
Kang WY, Hong SJ, Bae JH, Yang Z, Kim IS, Woo OH.   +5 more
europepmc   +1 more source