Results 131 to 140 of about 1,812,771 (319)

BIN1 regulates BACE1 intracellular trafficking and amyloid-β production

, 2016
BIN1 is a genetic risk factor of late-onset Alzheimer disease (AD), which was identified in multiple genome-wide association studies. BIN1 is a member of the amphiphysin family of proteins, and contains N-terminal Bin-Amphiphysin-Rvs and C-terminal Src ...
Morohashi Yuichi, Maehara Tomoaki, Yokoshima Satoshi, Prendergast George C., Hori Yukiko, Ebinuma Ihori, Tomita Taisuke, Chang Mee Young, Miyagawa Toji, Fukuyama Tohru, Tsuji Shoji, Hattori Haruhiko, Iwatsubo Takeshi   +12 more
core   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

BIOLOGICAL PROPERTIES OF ENTEROCOCCI OF VARIOUS ORIGINS

Журнал микробиологии, эпидемиологии и иммунобиологии, 2015
Aim. Study the prevalence and intensity of anti-hemoglobin and anti-lactoferrin activity in enterococci as representatives of symbiotic intestine microflora and causative agents of infection-inflammatory diseases in children. Materials and methods.
M. V Sycheva, O. L Kartashova
doaj  

Neurobartonelloses: emerging from obscurity!

Parasites & Vectors
Background Bartonella species are fastidious, intracellular bacteria responsible for an expanding array of human pathologies. Most are considered to be transmitted by direct inoculation with infected bodily fluids from a mammalian reservoir species or ...
Janice C. Bush, Cynthia Robveille, Ricardo G. Maggi, Edward B. Breitschwerdt   +3 more
doaj   +1 more source

Relationship between electrocardiogram and intracellular action potential or extracellular action potential

, 2007
P(論文)An analysis of the relation between electrocardiogram (ECG) and intracellular action potential in heart cells was performed using two considerations, that is, with the extracellular action potential induced from the differentiated intracellular ...
猪股, 孝四郎, 33021, INOMATA, Koshiro, 33019   +3 more
core  

Intracellular phase for an extracellular bacterial pathogen: MgtC shows the way

, 2015
Pseudomonas aeruginosa is an extracellular pathogen known to impair host phagocytic functions. However, our recent results identify MgtC as a novel actor in P.
Audrey Bernut, Bernut, Audrey, Belon, Claudine, Bleves, Sophie, Claudine Belon, Chantal Soscia, Sophie Bleves, Anne-Béatrice Blanc-Potard, Blanc-Potard, Anne-Béatrice, Soscia, Chantal   +9 more
core   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Bufei Jiedu Formula enhances CD40 activation and macrophage polarization to eliminate intracellular MRSA persisters

Frontiers in Immunology
BackgroundIntracellular methicillin-resistant Staphylococcus aureus (MRSA) represents a complex infection in clinical practice, characterized by its refractory and recurrent nature, rendering it challenging to treat with conventional antibiotics.
Shaoyan Zhang, Jiajun Chen, Lei Qiu, Xianwei Wu, Wei Zhou, Ruoqing Peng, Ya Feng, Rui Zhou, Xing Huang, Dingzhong Wu, Zhenhui Lu   +10 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source