Results 121 to 130 of about 3,321,426 (398)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Fatty Acylation of Phospholipase D1 on Cysteine Residues 240 and 241 Determines Localization on Intracellular Membranes [PDF]
, 1999 Jane M. Sugars +4 more
openalex +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
A nanoelectrode array for obtaining intracellular recordings from thousands of connected neurons
Nature Biomedical Engineering, 2019 Current electrophysiological or optical techniques cannot reliably perform simultaneous intracellular recordings from more than a few tens of neurons.
Jeffrey Abbott +9 more
semanticscholar +1 more source
Detection of intracellular antigens by flow cytometry: comparison of two chemical methods and microwave heating [PDF]
, 1998 Isabelle Millard +3 more
openalex +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Intracellular Developmental Timers [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2007 One of the most poorly understood aspects of animal development is how the timing of developmental events is controlled. In most vertebrate cell lineages, for example, precursor cells divide a limited number of times before they stop and terminally differentiate, but it is not known what controls when the cells stop dividing and differentiate. There is
openaire +2 more sources
Медицинская иммунологияThe immunomodulatory properties of probiotics largely depend on the metabolites secreted into the culture medium, which is studied as a cell-free supernatant and referred to as postbiotics. The aim of the present work was to conduct screening of cytokine
O. V. Bukharin +5 more
doaj +1 more source
Parasites & Vectors, 2014 Background Canine vector borne diseases (CVBDs) comprise illnesses caused by a spectrum of pathogens that are transmitted by arthropod vectors. Some dogs have persistent infections without apparent clinical, hematological or biochemical abnormalities ...
Nandhakumar Balakrishnan +4 more
doaj +1 more source