Results 101 to 110 of about 3,321,426 (398)

Intracellular Regulatory Networks are close to Monotone Systems [PDF]

, 2007
Several meso-scale biological intracellular regulatory networks that have specified directionality of interactions have been recently assembled from experimental literature.
Avi Ma', Eduardo D. Sontag, Ravi Iyengar   +2 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Artificial Intracellular Filaments

Cell Reports Physical Science, 2020
Intracellular protein filaments are ubiquitous for cellular functions, but forming bona fide biomimetic intracellular filaments of small molecules in living cells remains elusive. Here, we report the in situ formation of self-limiting intracellular filaments of a small peptide via enzymatic morphological transition of a phosphorylated and trimethylated
Zhaoqianqi Feng, Huaimin Wang, Fengbin Wang, Younghoon Oh, Cristina Berciu, Qiang Cui, Edward H. Egelman, Bing Xu   +7 more
openaire   +3 more sources

RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition

Nature Communications, 2017
RAF family kinases transmit signals from activated RAS at the plasma membrane to downstream kinases to control cell proliferation, differentiation and survival. Here the authors shed light on the molecular mechanisms whereby small molecule RAF inhibitors
Ting Jin, Hugo Lavoie, Malha Sahmi, Maud David, Christine Hilt, Amy Hammell, Marc Therrien   +6 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

PROTEIN PROFILE STRAIN SPECIFICITY OF BIFIDOBACTERIUM GENUS MEMBERS

Журнал микробиологии, эпидемиологии и иммунобиологии, 2015
Aim. Analysis of differences in protein spectra of various bifidobacteria strains of intestine microsymbiocenosis using identification results from MALDI-TOF mass-spectrometer. Materials and methods.
O. V Bukharin, T. F Stepanova, N. B Perunova, E. V Ivanova, S. V Andryuschenko, L. V Kataeva   +5 more
doaj  

High energy-charged cell factory for heterologous protein synthesis [PDF]

, 2009
Overexpression of gluconeogenic phosphoenolpyruvate carboxykinase (PCK) under glycolytic conditions enables Escherichia coli to maintain a greater intracellular ATP concentration and, consequently, to up-regulate genes for amino acid and nucleotide ...
Hye Jung Kim, Pil Kim, Sang Yup Lee, Yeong Deok Kwon   +3 more
core   +1 more source

Protein Pattern Formation

, 2018
Protein pattern formation is essential for the spatial organization of many intracellular processes like cell division, flagellum positioning, and chemotaxis.
A Desai, A Melbinger, A Touhami, A Treuner-Lange, A Varma, A-C Butty, AB Goryachev, AG Vecchiarelli, AJ Molendijk, AM Turing, B Goldstein, B Klünder, BD Corbin, D Schumacher, D Thalmeier, DA Ramirez-Diaz, David Fange, DM Raskin, DM Raskin, E Bi, E Mileykovskaya, E Munro, F Wu, Fabai Wu, FO Bendezu, G Bange, G Meacci, I Bose, IS Aranson, J Denk, J Denk, J Guckenheimer, J Halatek, J Halatek, J Halatek, J Halatek, J Lutkenhaus, J Lutkenhaus, J Männik, J Schweizer, JE Pearson, JS Schuhmacher, K Gerdes, K Zieske, K Zieske, K Zieske, K-T Park, KC Huang, KJ Lee, L Kozubowski, L Laan, L Reese, L Reese, LA Segel, LD Renner, LL Lackner, M Bonny, M Cross, M Kac, M Loose, M Loose, M Loose, M Loose, M Otsuji, MC Florian, NW Goehring, NW Goehring, NW Goehring, O Sliusarenko, P Gray, P Gray, P Gray, R Thom, R Wedlich-Soldner, RA Green, S Bergeler, S Kondo, S Kretschmer, T Freisinger, TH Szeto, V Ivanov, V Varga, V Varga, WM Bement, Y Caspi, Y Gu, Y-L Shih, Y-L Shih, Y-L Shih, Z Hu, Z Hu, Z Hu, Z Hu, Z Hu   +93 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source