Results 101 to 110 of about 1,812,771 (319)

Ryanodine receptors, a family of intracellular calcium ion channels, are expressed throughout early vertebrate development

, 2011
Background Calcium signals ([Ca2+]i) direct many aspects of embryo development but their regulation is not well characterised. Ryanodine receptors (RyRs) are a family of intracellular Ca2+ release channels that control the flux of Ca2+ from internal ...
Ashworth, R, Rachel Ashworth, Brennan Caroline, Wu Houdini HT, Brennan, C, Wu, HH, Ashworth Rachel, Caroline Brennan, Houdini HT Wu   +8 more
core   +1 more source

Functional adaptation of a plant receptor-kinase paved the way for the evolution of intracellular root symbioses with bacteria [PDF]

, 2008
Nitrogen-fixing root nodule symbioses (RNS) occur in two major forms-Actinorhiza and legume-rhizobium symbiosis-which differ in bacterial partner, intracellular infection pattern, and morphogenesis.
Markmann, Katharina, Parniske, Martin, Katharina Markmann, Giczey Gábor, Parniske Martin, Markmann Katharina, Gábor Giczey, Giczey, Gábor, Martin Parniske   +8 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Nanoparticle-based intra-cellular diagnostics [PDF]

, 2012
An in-depth understanding of biochemical processes occurring within the cell is a key factor for early diagnosis of disease and identification of appropriate treatment.
Korzeniowska, Barbara
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Palmitoylation of ULK1 by ZDHHC13 plays a crucial role in autophagy

Nature Communications
Autophagy is a highly conserved process from yeast to mammals in which intracellular materials are engulfed by a double-membrane organelle called autophagosome and degrading materials by fusing with the lysosome.
Keisuke Tabata, Kenta Imai, Koki Fukuda, Kentaro Yamamoto, Hayato Kunugi, Toshiharu Fujita, Tatsuya Kaminishi, Christian Tischer, Beate Neumann, Sabine Reither, Fatima Verissimo, Rainer Pepperkok, Tamotsu Yoshimori, Maho Hamasaki   +13 more
doaj   +1 more source

A rhodanine agent active against non-replicating intracellular Mycobacterium avium subspecies paratuberculosis. [PDF]

, 2009
BACKGROUND: Antibiotic therapy targeting chronic mycobacterial disease is often ineffective due to problems with the emergence of drug resistance and non-replicating persistent intracellular antibiotic resistant phenotypes.
Hermon-Taylor, J, Hinds Jason, Hinds, J, Bull Tim J, Hermon-Taylor John, Richard Linedale, Bull, TJ, Linedale Richard, Jason Hinds, Tim J Bull, John Hermon-Taylor, Linedale, R   +11 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Сomparative characteristics of cytokine profile induced in vitro by supernatants of industrial and intestinal strains of bifido- and lactobacteria

Медицинская иммунология
The immunomodulatory properties of probiotics largely depend on the metabolites secreted into the culture medium, which is studied as a cell-free supernatant and referred to as postbiotics. The aim of the present work was to conduct screening of cytokine
O. V. Bukharin, E. V. Ivanova, I. N. Chaynikova, N. B. Perunova, T. A. Bondarenko, A. V. Bekpergenova   +5 more
doaj   +1 more source

A re-examination of Hebbian-covariance rules and spike timing-dependent plasticity in cat visual cortex in vivo

Frontiers in Synaptic Neuroscience, 2010
Spike-Timing-Dependent Plasticity (STDP) is considered as an ubiquitous rule for associative plasticity in cortical networks in vitro. However, limited supporting evidence for its functional role has been provided in vivo.
Yves Frégnac, Marc ePananceau, Marc ePananceau, Alice René, Nazyed Huguet, Olivier Marre, manuel Levy, Daniel E Shulz   +7 more
doaj   +1 more source