Results 81 to 90 of about 3,321,426 (398)

Stimulation of Na⁺/H⁺ Exchanger Isoform 1 Promotes Microglial Migration [PDF]

, 2013
Regulation of microglial migration is not well understood. In this study, we proposed that Na+/H+ exchanger isoform 1 (NHE-1) is important in microglial migration.
A Bretscher, A Hall, Akemichi Baba, AM Woodward, B Hinz, B Masereel, C Frantz, C Martin, C Nolte, C Stock, CH Choi, Dandan Sun, DB Kintner, Dong Kim, GG Borisy, GW Kreutzberg, H Chen, H Kettenmann, HS Kim, Hui Yuan, J Luo, J Luo, K Nakamura, K Takeuchi, KP Yip, L Cartier, L Walter, L Yu, M Ghosh, M Ifuku, M Noda, M Noda, M Schliwa, MF Carlier, N Takayama, N Yonezawa, Pelin Cengiz, Peter Ferrazzano, PK Tucker, S Honda, SP Denker, SP Denker, T Matsuda, T Matsui, TM Gomez, Toshio Matsuda, Vishal Chanana, Y Liu, Y Shi, Yejie Shi, Zhe Zhang   +50 more
core   +3 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor. [PDF]

, 2016
Cellular amino acid uptake is critical for mTOR complex 1 (mTORC1) activation and cell proliferation. However, the regulation of amino acid uptake is not well-understood.
Braas, Daniel, Christofk, Heather R, Graeber, Thomas G, Krall, Abigail S, Xu, Shili   +4 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

THE ROLE OF BIFIDOBACTERIA IN THE FORMATION OF HUMAN IMMUNE HOMEOSTASIS

Журнал микробиологии, эпидемиологии и иммунобиологии, 2015
In the review the materials on the formation ofintestinal immune homeostasis through involvement of bifidobacteria which are the key species of microbiota of human colon biotype are presented.
O. V Bukharin, E. V Ivanova, N. B Perunova, I. N Chainikova   +3 more
doaj  

Serological and molecular analysis of feline vector-borne anaplasmosis and ehrlichiosis using species-specific peptides and PCR

Parasites & Vectors, 2015
Background With the exception of Bartonella spp. or Cytauxzoon felis, feline vector-borne pathogens (FVBP) have been less frequently studied in North America and are generally under-appreciated as a clinical entity in cats, as compared to dogs or people.
Barbara C. Hegarty, Barbara A. Qurollo, Brittany Thomas, Karen Park, Ramaswamy Chandrashekar, Melissa J. Beall, Brendon Thatcher, Edward B. Breitschwerdt   +7 more
doaj   +1 more source

Coxiella burnetii Blocks Intracellular Interleukin-17 Signaling in Macrophages [PDF]

, 2018
Coxiella burnetii is an obligate intracellular bacterium and the etiological agent of Q fever. Successful host cell infection requires the Coxiella type IVB secretion system (T4BSS), which translocates bacterial effector proteins across the vacuole ...
Clemente, Tatiana M., Gilk, Stacey D., Justis, Anna V., Mulye, Minal, Nallandhighal, Srinivas, Tran, Tuan M.   +5 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

INTRA-ERYTHROCYTE INVASION OF ESCHERICHIA COLI STRAINS WITH VARIOUS LEVELS OF ANTIHEMOGLOBIN ACTIVITY IN EXPERIMENT

Журнал микробиологии, эпидемиологии и иммунобиологии, 2015
Aim. Study of intra-erythrocyte invasion of Escherichia coli strains with various levels of antihemoglobin activity on a model of generalized infection. Materials and methods. Experiments were carried out on 72 male mice.
E. A Schuplova, S. B Fadeev, O. V Bukharin   +2 more
doaj  

PRODUCTION AND CHARACTERIZATION OF CRUDE INTRACELLULER PHYTASE FROM RECOMBINANT BACTERIA pEAS1AMP [PDF]

, 2009
This research was aimed at producing a crude intracellular phytase characterized from recombinant bacteria. The recombinant bacteria (pEAS1AMP) was produced by way of transforming pET-22b(+) +pEAS1 into competent E. coli BL21 and E.
Bachruddin, Z., Nuhriawangsa, A. M. P., SAJIDAN,, Wibowo, A.   +3 more
core