Results 161 to 170 of about 2,992,178 (408)

Poly I:C Delivery into J774.1 & RAW264.7 Macrophages Induces Rapid Cell Death [PDF]

open access: yesIranian Journal of Immunology, 2017
Background: Cytosolic double-stranded RNA (dsRNA) is an important ‘molecular signature’ for the detection of intracellular viral infections. Although intracellular dsRNA is a known potent inducer of apoptosis, the optimal time and dose for the onset of ...
Cheah Wen Yapp   +2 more
doaj  

Ventral tegmental area activation promotes firing precision and strength through circuit inhibition in the primary auditory cortex

open access: yesFrontiers in Neural Circuits, 2014
The activation of the ventral tegmental area (VTA) can rebuild the tonotopic representation in the primary auditory cortex (A1), but the cellular mechanisms remain largely unknown. Here, we investigated the firing patterns and membrane potential dynamics
Yunxiao eLou   +6 more
doaj   +1 more source

Tuning the kinetics of intracellular transport [PDF]

open access: yesarXiv
A variety of complex mechanisms, from chemical reaction pathways to active fluctuations, orchestrate molecular transport in intracellular environments. Despite significant recent progress in visualizing and probing these processes, little is known about how tunable the resulting dynamics is through external physical controllers.
arxiv  

Intracellular Communication [PDF]

open access: yesMolecular Plant, 2014
Grimm, Bernhard   +3 more
openaire   +2 more sources

Definition of intracellular pathogens [PDF]

open access: yesClinical Microbiology and Infection, 1996
Most microorganisms are destroyed by the host tissues through processes which usually involve phagocytosis and lysosomal disruption. However, some organisms are capable of growing inside macrophages and avoiding destruction. This paper describes the normal phagocytic process and how it is avoided by certain viruses, bacteria and protozoa, and the ...
openaire   +3 more sources

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

Vascular endothelial‐cadherin as a marker of endothelial injury in preclinical Alzheimer disease

open access: yesAnnals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1926-1940, December 2022., 2022
Abstract Objective Endothelial dysfunction is an early and prevalent pathology in Alzheimer disease (AD). We here investigate the value of vascular endothelial‐cadherin (VEC) as a cerebrospinal fluid (CSF) marker of endothelial injury in preclinical AD.
Rawan Tarawneh   +5 more
wiley   +1 more source

Cryoloading: Introducing Large Molecules into Live Synaptosomes

open access: yesFrontiers in Cellular Neuroscience, 2014
Neurons communicate with their target cells primarily by the release of chemical transmitters from presynaptic nerve terminals. The study of CNS presynaptic nerve terminals, isolated as synaptosomes (SSMs) has, however, been hampered by the typical ...
Arup R Nath   +2 more
doaj   +1 more source

Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis

open access: yesJournal of Experimental Medicine, 1997
Apoptosis and necrosis are considered conceptually and morphologically distinct forms of cell death. Here, we report that demise of human T cells caused by two classic apoptotic triggers (staurosporin and CD95 stimulation) changed from apoptosis to ...
M. Leist   +4 more
semanticscholar   +1 more source

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