Results 91 to 100 of about 3,145,194 (361)
Electrotonic signals along intracellular membranes may interconnect dendritic spines and nucleus. [PDF]
PLoS Computational Biology, 2008 Synapses on dendritic spines of pyramidal neurons show a remarkable ability to induce phosphorylation of transcription factors at the nuclear level with a short latency, incompatible with a diffusion process from the dendritic spines to the nucleus.
Isaac Shemer +3 more
doaj +1 more source
Membrane Trafficking: Intracellular Highways and Country Roads [PDF]
Plant Physiology, 2008 Membrane trafficking, or the flow of membrane material between endomembrane compartments and the plasmalemma, is essential for transport of proteins and other macromolecules to various destinations inside and outside of the cell.
Cheung, A.Y., de Vries, S.C.
openaire +4 more sources
Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
FEBS Letters, EarlyView.Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää +2 more
wiley +1 more source
iScience, 2022 Summary: Intracellular transport, regulated by complex cytoarchitectures and active driving forces, is crucial for biomolecule translocations and relates to many cellular functions.
Chao Jiang +5 more
doaj
Journal of Biological Chemistry, 1999 We have reported previously that phospholipase D1 (PLD1) is labeled specifically with [3H]palmitate following transient expression and immunoprecipitation and that this modification appeared important both for membrane localization and catalytic activity.
J. Sugars +4 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu +17 more
wiley +1 more source
Hopanoid lipids may facilitate aerobic nitrogen fixation in the ocean. [PDF]
, 2019 Cyanobacterial diazotrophs are considered to be the most important source of fixed N2 in the open ocean. Biological N2 fixation is catalyzed by the extremely O2-sensitive nitrogenase enzyme.
Cornejo-Castillo, Francisco M +1 more
core +1 more source
The SPCA1 Ca2+ Pump and Intracellular Membrane Trafficking [PDF]
Traffic, 2010 The Golgi apparatus (GA) is a dynamic store of Ca(2+) that can be released into the cell cytosol. It can thus participate in the regulation of the Ca(2+) concentration in the cytosol ([Ca(2+) ](cyt) ), which might be critical for intra-Golgi transport.
Massimo, Micaroni +4 more
openaire +5 more sources
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Biochemical Journal, 2001 The SHERP genes are found as a tandem pair within the differentially regulated LmcDNA16 locus of Leishmania major. The SHERP gene product (small hydrophilic endoplasmic reticulum-associated protein) is unusual in its small size (6.2 kDa), its acidic pI ...
E. Knuepfer +3 more
semanticscholar +1 more source