Results 101 to 110 of about 752,164 (352)

Mitochondrial Ca2+ uptake in skeletal muscle health and disease [PDF]

, 2016
Muscle uses Ca2+ as a messenger to control contraction and relies on ATP to maintain the intracellular Ca2+ homeostasis. Mitochondria are the major sub-cellular organelle of ATP production. With a negative inner membrane potential, mitochondria take up Ca2+ from their surroundings, a process called mitochondrial Ca2+ uptake.
arxiv   +1 more source

Membrane and inhibitor interactions of intracellular phospholipases A2 [PDF]

Advances in Biological Regulation, 2016
Studying phospholipases A2 (PLA2s) is a challenging task since they act on membrane-like aggregated substrates and not on monomeric phospholipids. Multidisciplinary approaches that include hydrogen/deuterium exchange mass spectrometry (DXMS) and computational techniques have been employed with great success in order to address important questions about
Mouchlis, Varnavas D, Dennis, Edward A
openaire   +4 more sources

Phagosome-lysosome fusion is a calcium-independent event in macrophages. [PDF]

, 1996
Phagosome-lysosome membrane fusion is a highly regulated event that is essential for intracellular killing of microorganisms. Functionally, it represents a form of polarized regulated secretion, which is classically dependent on increases in ...
Ernst, JD, Gustavsson, M, Majeed, M, Sanan, DA, Stendahl, O, Zimmerli, S   +5 more
core   +2 more sources

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

Molecular Oncology, EarlyView.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock, Lina Benzien, Sandra Lange, Maja Huehns, Alexandra Runge, Catrin Roolf, Anett Sekora, Gudrun Knuebel, Hugo Murua Escobar, Christian Junghanss, Anna Richter   +10 more
wiley   +1 more source

Oxidative photocatalysis on membranes triggers non-canonical pyroptosis

Nature Communications
Intracellular membranes composing organelles of eukaryotes include membrane proteins playing crucial roles in physiological functions. However, a comprehensive understanding of the cellular responses triggered by intracellular membrane-focused oxidative ...
Chaiheon Lee, Mingyu Park, W. C. Bhashini Wijesinghe, Seungjin Na, Chae Gyu Lee, Eunhye Hwang, Gwangsu Yoon, Jeong Kyeong Lee, Deok-Ho Roh, Yoon Hee Kwon, Jihyeon Yang, Sebastian A. Hughes, James E. Vince, Jeong Kon Seo, Duyoung Min, Tae-Hyuk Kwon   +15 more
doaj   +1 more source

A model of calcium-mediated coupling between membrane activity and clock gene expression in neurons of the suprachiasmatic nucleus [PDF]

arXiv, 2015
Rhythms in electrical activity in the membrane of cells in the suprachiasmatic nucleus (SCN) are crucial for the function of the circadian timing system, which is characterized by the expression of the so-called clock genes. Intracellular Ca$^{2+}$ ions seem to connect, at least in part, the electrical activity of SCN neurons with the expression of ...
arxiv  

Annexin-A5 assembled into two-dimensional arrays promotes cell membrane repair [PDF]

, 2011
Eukaryotic cells possess a universal repair machinery that ensures rapid resealing of plasma membrane disruptions. Before resealing, the torn membrane is submitted to considerable tension, which functions to expand the disruption.
A Brisson, A Brisson, AK McNeil, B Brachvogel, B Brachvogel, B Brachvogel, B Jeppesen, C Cai, C Cai, C Pigault, C Vénien-Bryan, CE Creutz, CJ Merrifield, D Bansal, D Bansal, D Voges, EB Babiychuk, F D'Acquisto, F Oling, F Oling, G Mosser, GQ Bi, HA Andree, I Reviakine, J Liu, JH Rand, K Balasubramanian, K Monastyrskaya, L Glover, M Menke, M Rodahl, MA Kaetzel, MA Swairjo, MP Sheetz, NJ Lennon, NO Concha, NO Concha, O Lambert, O Saurel, PL McNeil, PL McNeil, PL McNeil, Q Ling, R Bérat, R Huber, R Huber, R Langen, R Richter, RA Steinhardt, RP Richter, S Yasuda, SE Moss, T Skrahina, T Togo, T Yeung, V Gerke, Y Mo   +56 more
core   +2 more sources

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia

Molecular Oncology, EarlyView.
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar, Shima Shahbaz, Anthea C. Peters, Spencer B. Gibson, Shokrollah Elahi   +4 more
wiley   +1 more source

Investigating the role of viral integral membrane proteins in promoting the assembly of nepovirus and comovirus replication factories

Frontiers in Plant Science, 2013
Formation of plant virus membrane-associated replication factories requires the association of viral replication proteins and viral RNA with intracellular membranes, the recruitment of host factors and the modification of membranes to form novel ...
Helene eSanfacon
doaj   +1 more source

The Effects of Regulatory Lipids on Intracellular Membrane Fusion Mediated by Dynamin-Like GTPases

Frontiers in Cell and Developmental Biology, 2020
Membrane fusion mediates a number of fundamental biological processes such as intracellular membrane trafficking, fertilization, and viral infection. Biological membranes are composed of lipids and proteins; while lipids generally play a structural role,
Yeojin Moon, Youngsoo Jun
doaj   +1 more source