Results 101 to 110 of about 365,824 (219)

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

Macrophage Membrane‐Cloaked, ROS‐Triggered Quercetin Nanocarriers Target Ovarian Lesions to Treat Polycystic Ovary Syndrome

Advanced Healthcare Materials, EarlyView.
The synthesis process of MM@PCD@QNPs and its potential mechanism for treating PCOS. (A) Assembly steps of MM@PCD@QNPs. (B) Synthesis and decomposition of MM@PCD@QNPs. (C) Potential therapeutic mechanisms of MM@PCD@QNPs for PCOS. PCD, PABP conjugated with DEX polymer; QUR, quercetin; CDI, N, N′‐carbonyldiimidazole; DEX, dextran; PABP, 4‐(hydroxymethyl ...
Wenzhu Li, Yu Guan, Nan Song, Feng Zhang, Zhimin Deng, Tailang Yin, Yanbing Yang, João Conde, Wenyi Jin, Zhinang Yin   +9 more
wiley   +1 more source

Metabolic flux analysis for metabolome data validation of naturally xylose-fermenting yeasts

BMC Biotechnology, 2019
Background Efficient xylose fermentation still demands knowledge regarding xylose catabolism. In this study, metabolic flux analysis (MFA) and metabolomics were used to improve our understanding of xylose metabolism.
Henrique C. T. Veras, Christiane G. Campos, Igor F. Nascimento, Patrícia V. Abdelnur, João R. M. Almeida, Nádia S. Parachin   +5 more
doaj   +1 more source

Oxygen and ROS Delivery for Infected Wound Healing and Future Prospects

Advanced Healthcare Materials, EarlyView.
Bacterial infection is a major driver of delayed wound healing and postsurgical readmissions; with rising antibiotic resistance, solid peroxide–releasing biomaterials offer sustained delivery of ROS/O2 for antimicrobial control and microenvironmental modulation.
Ayden Watt, Chably Rachella, Charlotte Jaloux, Joshua Vorstenbosch, Adam Hart, Michael Tanzer, Geraldine Merle, Jake Barralet   +7 more
wiley   +1 more source

Metabolic reprogramming dynamics in tumor spheroids: Insights from a multicellular, multiscale model.

PLoS Computational Biology, 2019
Mathematical modeling provides the predictive ability to understand the metabolic reprogramming and complex pathways that mediate cancer cells' proliferation.
Mahua Roy, Stacey D Finley
doaj   +1 more source

Raman spectroscopy online monitoring of biomass production, intracellular metabolites and carbon substrates during submerged fermentation of oleaginous and carotenogenic microorganisms. [PDF]

Microb Cell Fact, 2023
Dzurendova S, Olsen PM, Byrtusová D, Tafintseva V, Shapaval V, Horn SJ, Kohler A, Szotkowski M, Marova I, Zimmermann B.   +9 more
europepmc   +1 more source

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, EarlyView.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source

Population pharmacokinetics of tenofovir, emtricitabine and intracellular metabolites in transgender women. [PDF]

Br J Clin Pharmacol, 2022
Tanaudommongkon A, Chaturvedula A, Hendrix CW, Fuchs EJ, Shieh E, Bakshi RP, Marzinke MA.   +6 more
europepmc   +1 more source

Host glutathione is required for Rickettsia parkeri cell division and intracellular survival

Nature Communications
Intracellular bacteria rely on eukaryotic metabolites for their fitness and pathogenesis. Yet, the mechanisms of how host metabolites promote bacterial physiology and immune evasion are often unclear.
Han Sun, Anh Phuong Luu, Meggie Danielson, Thomas P. Burke   +3 more
doaj   +1 more source

RTGill-W1 Cells Response to Salmonella enterica Metabolites

Bacteria
This report investigates the interaction between the metabolites of the highly virulent bacteria Salmonella enterica and RTGill-W1 cells, a cell line derived from rainbow trout gills.
Abdulhusein Jawdhari, Robert Wolff, Bianca-Maria Tihăuan, Irina-Tania Ghitoc, Nicolae Crăciun   +4 more
doaj   +1 more source