Results 121 to 130 of about 365,824 (219)

Deep learning reveals endogenous sterols as allosteric modulators of the GPCR–Gα interface

eLife
Endogenous intracellular allosteric modulators of GPCRs remain largely unexplored, with limited binding and phenotype data available. This gap arises from the lack of robust computational methods for unbiased cavity identification, cavity-specific ligand
Sanjay Kumar Mohanty, Aayushi Mittal, Namra Farooqi, Aakash Gaur, Subhadeep Duari, Saveena Solanki, Anmol Kumar Sharma, Sakshi Arora, Suvendu Kumar, Vishakha Gautam, Nilesh Kumar Dixit, Karthika Subramanian, Tarini Shankar Ghosh, Debarka Sengupta, Shashi Kumar Gupta, Arul Natarajan Murugan, Deepak Sharma, Gaurav Ahuja   +17 more
doaj   +1 more source

Metabolomics profiles of the liquid co-culture of Sanghuangporus vaninii and Pleurotus sapidus

Frontiers in Sustainable Food Systems
IntroductionFungal secondary metabolites (SMs) have broad application prospects in the food and medicine industries. Co-culturing strategies that simulate natural symbiotic relationships among microorganisms are used to discover and enhance the ...
Yuantian Lu, Di Liu, Di Liu
doaj   +1 more source

The Noncanonical Functions of Metabolites in Tumor Progression

Metabolites
Metabolic reprogramming has emerged as a prominent hallmark of cancer, characterized by substantial alterations in nutrient uptake and intracellular metabolic pathways.
Siyang Wu, Yijun Qi, Weiwei Yang
doaj   +1 more source

Muscle Fatigue from the Perspective of a Single Crossbridge [PDF]

, 2016
The repeated intense stimulation of skeletal muscle rapidly decreases its force- and motion-generating capacity. This type of fatigue can be temporally correlated with the accumulation of metabolic by-products, including phosphate (Pi) and protons (H ...
Debold, Edward Patrick, Fitts, Robert H., Nosek, Thomas M., Sundberg, Christopher W.   +3 more
core   +1 more source

Effect of ozone stress on the intracellular metabolites from Cobetia marina. [PDF]

Anal Bioanal Chem, 2020
Li J, Rumancev C, Lutze HV, Schmidt TC, Rosenhahn A, Schmitz OJ.   +5 more
europepmc   +1 more source

INTERCELLULAR AND INTRACELLULAR TRAFFICKING OF NAD+ AND NAD+ PRECURSORS, INTERMEDIATE METABOLITES AND SIGNAL METABOLITES

Journal of the Siena Academy of Sciences, 2012
n ...
openaire   +3 more sources

Antioxidative and Cytoprotective Effects of Rosa Roxburghii and Metabolite Changes in Oxidative Stress-Induced HepG2 Cells Following Rosa Roxburghii Intervention

Foods
Rosa Roxburghii (RR), a traditional Chinese medicinal fruit, is rich in bioactive substances that make it a potential natural antioxidant resource.
Yangchen Mao, Ruyi Sha, Yuhao Sun, Zhenzhen Wang, Jun Huang   +4 more
doaj   +1 more source

GC-MS-Based Metabolomics for the Smut Fungus Ustilago maydis: A Comprehensive Method Optimization to Quantify Intracellular Metabolites. [PDF]

Front Mol Biosci, 2020
Phan ANT, Blank LM.
europepmc   +1 more source

Lactate: an intracellular metabolite regulates cell cycle progression

Life Metabolism, 2023
Cheng, Jinke, Yeh, Edward T H
openaire   +1 more source

Mass Isotopologue Distribution of dimer ion adducts of intracellular metabolites for potential applications in 13C Metabolic Flux Analysis. [PDF]

PLoS One, 2019
Prasannan CB, Mishra V, Jaiswal D, Wangikar PP.   +3 more
europepmc   +1 more source