Results 41 to 50 of about 365,824 (219)

Ketamine: NMDA receptors and beyond [PDF]

, 2016
Human studies examining the effects of the dissociative anesthetic ketamine as a model for psychosis and as a rapidly acting antidepressant have spurred great interest in understanding ketamine's actions at molecular, cellular, and network levels ...
Izumi, Yukitoshi, Mennerick, Steven, Zorumski, Charles F   +2 more
core   +2 more sources

Augmenting Biogas Process Modeling by Resolving Intracellular Metabolic Activity [PDF]

, 2019
The process of anaerobic digestion in which waste biomass is transformed to methane by complex microbial communities has been modeled for more than 16 years by parametric gray box approaches that simplify process biology and do not resolve intracellular ...
Denny Popp, Dirk Benndorf, Dirk Benndorf, Fabian Bonk, Florian Centler, Sabine Koch, Steffen Klamt, Sören Weinrich   +7 more
core   +1 more source

Intracellular and Extracellular Metabolic Response of the Lactic Acid Bacterium Weissella confusa Under Salt Stress

Metabolites
Background: Weissella confusa is a member of the lactic acid bacterium group commonly found in many salt-fermented foods. Strains of W. confusa isolated from high-salinity environments have been shown to tolerate salt stress to some extent.
Ali Wang, Qinqin Du, Xiaomin Li, Yimin Cui, Jiahua Luo, Cairong Li, Chong Peng, Xianfeng Zhong, Guidong Huang   +8 more
doaj   +1 more source

Decreased glutathione biosynthesis contributes to EGFR T790M-driven erlotinib resistance in non-small cell lung cancer [PDF]

, 2016
Epidermal growth factor receptor (EGFR) inhibitors such as erlotinib are novel effective agents in the treatment of EGFR-driven lung cancer, but their clinical impact is often impaired by acquired drug resistance through the secondary T790M EGFR mutation.
Chater, E, De Bruin, E, Downward, J, Heynen, GJJE, Hu, Y, Li, H, Liu, Z, Pardo, OE, Roy, R, Seckl, MJS, Smit, EF, Stokes, W, Tang, H, Wang, Y   +13 more
core   +2 more sources

Analysing intracellular isoprenoid metabolites in diverse prokaryotic and eukaryotic microbes

, 2022
Isoprenoids, also known as terpenes or terpenoids, are a very large and diverse group of natural compounds. These compounds fulfil a myriad of critical roles in biology as well as having a wide range of industrial uses. Isoprenoids are produced via two chemically distinct metabolic pathways, the mevalonate (MVA) pathway and the methylerythritol ...
Plan, Manuel, Bongers, Mareike, Bydder, Sarah, Fabris, Michele, Hodson, Mark P., Kelly, Erin, Krömer, Jens, Perez-Gil, Jordi, Peng, Bingyin, Satta, Alessandro, Schrübbers, Lars C., Vickers, Claudia E.   +11 more
openaire   +5 more sources

Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids. [PDF]

, 2016
The beta amyloid (Aβ) and other aggregating proteins in the brain increase with age and are frequently found within neurons. The mechanistic relationship between intracellular amyloid, aging and neurodegeneration is not, however, well understood.
Currais, Antonio, Daugherty, Daniel, M Armando, Aaron, Maher, Pam, Quehenberger, Oswald, Schubert, David   +5 more
core   +2 more sources

Intracellular Metabolomics Switching Alters Extracellular Acid Production and Insoluble Phosphate Solubilization Behavior in Penicillium oxalicum

Metabolites, 2020
This research aims to understand the precise intracellular metabolic processes of how microbes solubilize insoluble phosphorus (Insol-P) to increase bio-available P. Newly isolated Penicillium oxalicum PSF-4 exhibited outstanding tricalcium phosphate (TP)
Yifan Jiang, Fei Ge, Feng Li, Dayi Zhang, Songqiang Deng, Jiang Tian   +5 more
doaj   +1 more source

Effect of cyclosporine on hepatic energy status and on fructose metabolism after portacaval shunt in dog as monitored by phosphorus‐31 nuclear magnetic resonance spectroscopy in vivo [PDF]

, 1991
The effect of cyclosporin A on the hepatic energy status and intracellular pH of the liver and its response to a fructose challenge has been investigated using in vivo phosphorus‐31 nuclear magnetic resonance spectroscopy in dogs.
Atkinson, Avison, Baldassarri, Bode, Bäckman, Calne, Cohen, Evelhoch, Francavilla, Grant, Harder, Iles, Iles, Kahn, Kim, Kim, Klintmalm, Laupacis, Loertscher, Lorber, Makowka, Mazzaferro, Otte, Powles, Roos, Rossaro, Schade, Seo, Stacey, Starzl, Starzl, Starzl, Starzl, Starzl, Stone, Thompson, Van Thiel, Ziegler   +37 more
core   +1 more source

Intracellular metabolite profiling of Saccharomyces cerevisiae evolved under furfural

Microbial Biotechnology, 2016
Summary Furfural, one of the most common inhibitors in pre‐treatment hydrolysates, reduces the cell growth and ethanol production of yeast. Evolutionary engineering has been used as a selection scheme to obtain yeast strains that exhibit furfural tolerance.
Jung, Young Hoon, Kim, Sooah, Yang, Jungwoo, Seo, Jin‐Ho, Kim, Kyoung Heon   +4 more
openaire   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source