Results 51 to 60 of about 365,824 (219)

Ketamine Metabolites Enantioselectively Decrease Intracellular D-Serine Concentrations in PC-12 Cells. [PDF]

PLoS ONE, 2016
D-Serine is an endogenous NMDA receptor co-agonist that activates synaptic NMDA receptors modulating neuronal networks in the cerebral cortex and plays a key role in long-term potentiation of synaptic transmission.
Nagendra S Singh, Ewelina Rutkowska, Anita Plazinska, Mohammed Khadeer, Ruin Moaddel, Krzysztof Jozwiak, Michel Bernier, Irving W Wainer   +7 more
doaj   +1 more source

Antifungal potential of volatiles produced by Bacillus subtilis BS-01 against Alternaria solani in Solanum lycopersicum

Frontiers in Plant Science, 2023
Bacterial biocontrol agent/s (BCAs) against plant diseases are eco-friendly and sustainable options for profitable agricultural crop production. Specific beneficial strains of Bacillus subtilis are effective in controlling many fungal diseases including ...
Zoia Arshad Awan, Amna Shoaib, Peer M. Schenk, Ajaz Ahmad, Saleh Alansi, Bilal Ahamad Paray   +5 more
doaj   +1 more source

Arachidonic Acid as a Possible Negative Feedback Inhibitor of Nicotinic Acetylcholine Receptors on Neurons [PDF]

, 1995
Neuronal acetylcholine receptors, being highly permeable to calcium, are likely to regulate calcium-dependent events in neurons. Arachidonic acid is a membrane-permeant second messenger that can be released from membrane phospholipids by phospholipases ...
Berg, Darwin K., Blumenthal, Edward M, Huang, Bo, Vijayaraghavan, Sukumar   +3 more
core   +2 more sources

Childhood leukaemia: a relationship between intracellular 6‐ mercaptopurine metabolites and neutropenia. [PDF]

British Journal of Clinical Pharmacology, 1983
6‐Mercaptopurine is extensively used in the treatment of childhood lymphoblastic leukaemia to prolong the duration of remission achieved with other drugs. The response to remission maintenance therapy varies widely. We investigated the relationship between red blood cell 6‐ thioguanine nucleotide, a metabolite of 6‐mercaptopurine, and myelosuppression ...
L, Lennard, C A, Rees, J S, Lilleyman, J L, Maddocks   +3 more
openaire   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Water extract of Cryphaea heteromalla (Hedw.) D. Mohr bryophyte as a natural powerful source of biologically active compounds [PDF]

, 2019
Bryophytes comprise of the mosses, liverworts, and hornworts. Cryphaea heteromalla, (Hedw.) D. Mohr, is a non-vascular lower plant belonging to mosses group. To the date, the most chemically characterized species belong to the liverworts, while only 3.2%
Biagio P. L. S., Campisi P., Costa M. A., Dia M. G., Ditta L. A., Giacomazza D., Linares I. B., Passantino R., Provenzano F., Rao E., Sanchez J. L., Santonocito R., Segura-Carretero A.   +12 more
core   +1 more source

Intracellular Delivery of Biologically-Active Fungal Metabolite Gliotoxin Using Magnetic Nanoparticles [PDF]

Materials, 2019
Gliotoxin (GT), a secondary metabolite produced by Aspergillus molds, has been proposed as a potential anti-tumor agent. Here we have developed a nanoparticle approach to enhance delivery of GT in tumor cells and establish a basis for its potential use as therapeutical drug. GT bound to magnetic nanoparticles (MNPs) retained a high anti-tumor activity,
Laura Comas, Esther Polo, M Domingo, Yulán Hernández, Maykel Arias, Patricia Esteban, Luis Martínez-Lostao, Julián Pardo, Jesús Martínez de la Fuente, Eva Gálvez   +9 more
openaire   +6 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Study of intracellular anabolism of 5-fluorouracil and incorporation in nucleic acids based on an LC-HRMS method

Journal of Pharmaceutical Analysis, 2021
5-Fluorouracil (5-FU) is an anticancer drug extensively used for different cancers. Intracellular metabolic activation leads to several nucleoside and nucleotide metabolites essential to exert its cytotoxic activity on multiple cellular targets such as ...
Christelle Machon, Frédéric Catez, Nicole Dalla Venezia, Floriane Vanhalle, Laetitia Guyot, Anne Vincent, Maxime Garcia, Béatrice Roy, Jean-Jacques Diaz, Jérôme Guitton   +9 more
doaj   +1 more source

Comparative genomics of Burkholderia multivorans, a ubiquitous pathogen with a highly conserved genomic structure [PDF]

, 2017
The natural environment serves as a reservoir of opportunistic pathogens. A well-established method for studying the epidemiology of such opportunists is multilocus sequence typing, which in many cases has defined strains predisposed to causing infection.
Peeters, Charlotte, Cooper, Vaughn S, Hatcher, Philip J, Verheyde, Bart, Carlier, Aurélien, Vandamme, Peter   +5 more
core   +3 more sources