Results 81 to 90 of about 65,062 (302)

Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell‐Type‐Specific TGFβ Modulators

Advanced Science, EarlyView.
The mammalian TGFβ interacts with ubiquitously expressed TGFBR1 and TGFBR2, and current TGFβ‐targeting agents are non‐cell‐selective. The cooperative interaction of the modular parasite TGFβ antagonist with multiple host (co‐)receptors empowers the design of TGM chimeras and bispecific antibodies that activate or inhibit TGFβ signaling in a cell ...
Maarten van Dinther, Tristin Schwartze, Jiying Zhang, Kun Fan, Gerard van der Zon, Luke Power, Cynthia S. Hinck, Claire Ciancia, Ananya Mukundan, Roman Gonzalez‐Prieto, Peter van Veelen, Rick M. Maizels, Andrew P. Hinck, Peter ten Dijke   +13 more
wiley   +1 more source

Mechanisms of infectivity and evasion derived from microvesicles cargo produced by Trypanosoma cruzi

Frontiers in Cellular and Infection Microbiology, 2016
Cell invasion by the intracellular protozoans requires interaction of proteins from both the host and the parasite. Many parasites establish chronic infections, showing they have the potential to escape the immune system; for example, Trypanosoma cruzi ...
Bruna Cristina Borges, Isadora Akemi Uehara, Laysa Oliveira Santos Dias, Paula Cristina Brígido, Claudio Vieira Silva, Marcelo J B Silva   +5 more
doaj   +1 more source

Invasion and intracellular survival by protozoan parasites [PDF]

Immunological Reviews, 2011
Summary:  Intracellular parasitism has arisen only a few times during the long ancestry of protozoan parasites including in diverse groups such as microsporidians, kinetoplastids, and apicomplexans. Strategies used to gain entry differ widely from injection (e.g. microsporidians), active penetration of the host cell (e.g.
openaire   +2 more sources

Identification of T. gondii myosin light chain-1 as a direct target of TachypleginA-2, a small-molecule inhibitor of parasite motility and invasion

, 2014
This work was supported by US Public Health Service grant AI054961 (GEW/NJW), a University Research Fellowship from the Royal Society (NJW) and funding for the mass spectrometry analysis was provided by the Vermont Genetics Network/NIH Grant 8P20GM103449
Pathak, R.B., Bryan A. Ballif (238963), Nicholas J Westwood, Westwood, N.J., Gary E Ward, Leung, J.M., Jacqueline M Leung, Poupart, S., Ward, G.E., Nicholas J. Westwood (254891), Séverine Poupart (571871), Gary E. Ward (208054), Ballif, B.A., Séverine Poupart, Tran, F., Aoife T. Heaslip (207534), Bryan A Ballif, Fanny Tran, Aoife T Heaslip, Fanny Tran (571869), Jacqueline M. Leung (120235), Heaslip, A.T., Ravindra B Pathak, Ravindra B. Pathak (571870)   +23 more
core   +1 more source

Dual‐Network Protein Hydrogels Promote Rapid Hemostasis and Immune‐Regulated Scarless Tissue Regeneration

Advanced Science, EarlyView.
A dual‐network protein hydrogel substantially improves hemostasis and scar‐free healing.The adaptive network maintains intimate tissue contact while providing strong wet adhesion, tunable mechanics, and controlled degradation. Concurrent ROS scavenging and M2 polarization suppress fibrotic pathways, preventing scar formation.
Xiaomei Li, Guorui Zhang, Xinyue Wang, Zhongyu Liu, Ling Yang, Yuhan Bao, Min Wei, Yonglin Chen, Yanfei Ma, Wenbo Sheng, Bo Yu, Bin Li   +11 more
wiley   +1 more source

Cyst Detection in Toxoplasma gondii Infected Mice and Rats Brain

Bio-Protocol, 2015
Toxoplasmosis caused by the intracellular parasite Toxoplasma gondii, is characterized by a life-long chronic infection. The parasite is an efficient neurotropic infectious agent that establishes its “safe” life by forming intracellular cysts in ...
Valeria Bellini, Corinne Loeuillet, Céline Massera, Marie-France Cesbron-Delauw, Pierre Cavaillès   +4 more
doaj   +1 more source

No evidence for Ago2 translocation from the host erythrocyte into the Plasmodium parasite [version 2; peer review: 2 approved]

Wellcome Open Research, 2020
Background: Plasmodium parasites rely on various host factors to grow and replicate within red blood cells (RBC). While many host proteins are known that mediate parasite adhesion and invasion, few examples of host enzymes co-opted by the parasite during
Franziska Hentzschel, Klara Obrova, Matthias Marti   +2 more
doaj   +1 more source

Aptamer‐Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis

Advanced Science, EarlyView.
This study presents an injectable DNA‐based porous hydrogel integrating catechol motifs and targeting aptamers for pulpitis management. Upon in situ crosslinking, the scaffold actively recruits endogenous dental pulp stem cells, restores redox homeostasis, and modulates immune responses.
Luhui Cai, Huan Yu, Zihan Ni, Kan Chen, I‐Chen Tsai, Zeyu Bao, Shuo Sun, Weichang Li, Yunhua Chen, Qiong Xu   +9 more
wiley   +1 more source

Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy

Advanced Science, EarlyView.
A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang, Yubo Lai, Jia Wang, Lingling Liu, Jieyuan An, Mi Qu, Yuan Liang, Bijun Tan, Guodong Yang, Xuekang Yang, Lijun Yuan   +10 more
wiley   +1 more source

Toxoplasma gondii - intracellular parasite

, 2002
Tue article presents selected data concerning invasion and intracellular life of obligate intracellular parasite Toxoplasma gondii in susceptible ...
Długońska, H.
core