Results 71 to 80 of about 65,062 (302)

Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures

mBio, 2016
Macrophages are mononuclear phagocytes that constitute a first line of defense against pathogens. While lethal to many microbes, they are the primary host cells of Leishmania spp.
Maria Cecilia Fernandes, Laura A. L. Dillon, Ashton Trey Belew, Hector Corrada Bravo, David M. Mosser, Najib M. El-Sayed   +5 more
doaj   +1 more source

Spatiotemporal and functional characterisation of the Plasmodium falciparum cGMP-dependent protein kinase. [PDF]

, 2012
Signalling by 3'-5'-cyclic guanosine monophosphate (cGMP) exists in virtually all eukaryotes. In the apicomplexan parasite Plasmodium, the cGMP-dependent protein kinase (PKG) has previously been reported to play a critical role in four key stages of the ...
Baker, David A, Lev Solyakov (122244), Solyakov, Lev, David A Baker, Flueck, Christian, Lev Solyakov, L. Solyakov (7638338), Hopp Christine S., Flueck Christian, Andrew Tobin (122248), David A. Baker (122252), Christine S Hopp, David A. Baker, D. A. Baker (7638335), A. B. Tobin (7638326), Solyakov Lev, C. Flueck (7638332), Andrew Tobin, Christine S. Hopp (122239), Baker David A., Tobin Andrew, Christian Flueck, C. S. Hopp (7638329), Tobin, Andrew, Christian Flueck (122240), Hopp, Christine S   +25 more
core   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Hiding inside the host: development and application of "Neospora caninum" bradyzoite in vitro culture [PDF]

, 2003
The bradyzoite stage of the apicomplexan parasite Neospora caninum represents a hypobiotic, slowly proliferating and tissue cyst forming stage, which can survive in the immunocompetent host for several years. Tissue cysts are orally infectious.
Vonlaufen, Nathalie
core   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

A Computational Strategy for Identifying Self‐Assembling Food‐Derived Molecules for Antiparasitic Nanotherapy

Advanced Science, EarlyView.
An integrated computational screening strategy identified ursolic acid (UA) and 18β‐glycyrrhetinic acid (18βGA) as a self‐assembling food‐derived molecular pair. The resulting carrier‐free nanoparticles (UA‐18βGA) showed synergistic antiparasitic activity, reduced combined toxicity, and host‐protective anti‐inflammatory effects in zebrafish and murine ...
Shenye Qu, Ting Wang, Jietao Liu, Jiacheng Qin, Bin Yang, Yihang Liu, Pengfei Li, Gaoxue Wang, Fei Ling   +8 more
wiley   +1 more source

Bioadhesive Hydrogel With Polyphenol‐Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy

Advanced Science, EarlyView.
An adhesive hydrogel depot with polyphenol‐armored nanogenes is developed for treating aged osteoarthritis. This system maintains miR‐140 bioactivity, prolongs its intra‐articular retention, and enhances transfection into chondrocytes, leading to the downregulation of senescence‐associated pathways.
Liwei Yan, Runze Yang, Ting Zhou, Tianhao Xu, Yongqi Li, Yuelin Hu, Minghao Ge, Lei Zhang, Xiong Lu, Chaoming Xie, Weili Fu   +10 more
wiley   +1 more source

Regulation of PKC mediated signaling by calcium during visceral leishmaniasis.

PLoS ONE, 2014
Calcium is an ubiquitous cellular signaling molecule that controls a variety of cellular processes and is strictly maintained in the cellular compartments by the coordination of various Ca2+ pumps and channels.
Nivedita Roy, Supriya Chakraborty, Bidisha Paul Chowdhury, Sayantan Banerjee, Kuntal Halder, Saikat Majumder, Subrata Majumdar, Parimal C Sen   +7 more
doaj   +1 more source

Functional Disorder at the Neural Interface: How Disordered Nanostructures Promote Proper Growth and Differentiation in In Vitro Neural Cultures

Advanced Science, EarlyView.
This work provides a practical guide for neuroengineers to design advanced neural interfaces, embracing and tailoring the concept of functional disorder. By bridging 2D and 3D in vitro models, this work highlights how non‐periodic, spatially heterogeneous, multiscale nanotopography can enable more physiologically relevant platforms for studying neural ...
F. Maita, E. Palmieri, I. Lucarini, L. Montaina, L. Maiolo   +4 more
wiley   +1 more source

Calcium-binding protein TgpCaBP regulates calcium storage of the zoonotic parasite Toxoplasma gondii

Microbiology Spectrum
Toxoplasma gondii, the causative parasite of toxoplasmosis, is an apicomplexan parasite that infects warm-blooded mammals. The ability of the calcium-binding proteins (CBPs) to transport large amounts of Ca2+ appears to be critical for the biological ...
Weisong Sun, Ning Jiang, Qilong Li, Yize Liu, Yiwei Zhang, Ran Chen, Ying Feng, Xiaoyu Sang, Shaojun Long, Qijun Chen   +9 more
doaj   +1 more source