Results 51 to 60 of about 65,062 (302)

A combination of four Toxoplasma gondii nuclear-targeted effectors protects against interferon gamma-driven human host cell death

mBio
In both mice and humans, Type II interferon gamma (IFNγ) is crucial for the regulation of Toxoplasma gondii (T. gondii) infection, during acute or chronic phases. To thwart this defense, T.
Brittany Henry, Aubrey J. Phillips, L. David Sibley, Alex Rosenberg   +3 more
doaj   +1 more source

Toxoplasma gondii Ingests and Digests Host Cytosolic Proteins

mBio, 2014
The protozoan parasite Toxoplasma gondii resides within a nonfusogenic vacuole during intracellular replication. Although the limiting membrane of this vacuole provides a protective barrier to acidification and degradation by lysosomal hydrolases, it ...
Zhicheng Dou, Olivia L. McGovern, Manlio Di Cristina, Vern B. Carruthers   +3 more
doaj   +1 more source

Identification of TgCBAP, a novel cytoskeletal protein that localizes to three distinct subcompartments of the toxoplasma gondii pellicle

, 2014
This work was supported by US Public Health Service grant AI054961 (GEW).The cytoskeletons of Toxoplasma gondii and related apicomplexan parasites are highly polarized, with apical and basal regions comprised of distinct protein complexes.
Lucas D Tilley, Shruthi Krishnamurthy (571344), Nicholas J. Westwood (254891), Shruthi Krishnamurthy, Gary E. Ward (208054), Tilley, Lucas D., Lucas D. Tilley (208044), Nicholas J Westwood, Krishnamurthy, Shruthi, Gary E Ward, Westwood, Nicholas J., Ward, Gary E.   +11 more
core   +1 more source

Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application

Advanced Materials, EarlyView.
This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong, You Zhou, Qingxiu Li, Wenyu Zhao, Sunyingyue Geng, Hangfei Li, Yan‐Bing Leng, Shirui Zhu, Guanglong Ding, Yongbiao Zhai, Ziyu Lv, Ye Zhou, Su‐Ting Han   +12 more
wiley   +1 more source

The intracellular parasite Theileria parva protects infected T cells from apoptosis.

, 1999
Parasites have evolved a plethora of strategies to ensure their survival. The intracellular parasite Theileria parva secures its propagation and spreads through the infected animal by infecting and transforming T cells, inducing their continuous ...
Chen, C G, Fernandez, P C, Heussler, Volker, Pearse, M J, Chao-Guang Chen, Volker T. Heussler, Botteron, C, Paula C. Fernandez, Joel Machado, Martin J. Pearse, Catherine Botteron, Machado, J, Dirk A. E. Dobbelaere, Dobbelaere, D A   +13 more
core   +1 more source

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

Microsporidian obligate intracellular parasites subvert autophagy of infected mammalian cells to promote their own growth

mBio
Intracellular pathogens such as Microsporidia can interfere with host proteostasis pathways, including autophagy. While the manipulation of host autophagy has been demonstrated in a nematode-infecting species, and autophagic activity was also observed in
Johan Panek, Eugenie Carriere, Moudy Bin Saleh, Kacper Sendra, Gregor Kosta, Viktor I. Korolchuk, Robert P. Hirt   +6 more
doaj   +1 more source

Adhesion of Toxoplasma gondii tachyzoite-infected vehicle leukocytes to capillary endothelial cells triggers timely parasite egression

Scientific Reports, 2017
Intracellular pathogens have numerous strategies for effective dissemination within the host. Many intracellular pathogens first infect leukocytes, which they use as a vehicle to transport them to target organs.
Minami Baba, Tatiana Batanova, Katsuya Kitoh, Yasuhiro Takashima   +3 more
doaj   +1 more source

Metabolic systems biology of the malaria parasite [PDF]

, 2012
Quantitative one-dimensional proton NMR metabolomics is performed on growth medium samples gathered at up to ten time-points during the in vitro culture of P. falciparum in human red blood cells. From this study, exchange fluxes between the parasite-host
Forth, Thomas
core  

Sphingolipid synthesis and scavenging in the intracellular apicomplexan parasite, Toxoplasma gondii [PDF]

, 2012
Sphingolipids are essential components of eukaryotic cell membranes, particularly the plasma membrane, and are involved in a diverse array of signal transduction pathways.
Steven Pratt, Nilu Wansadhipathi-Kannangara, Catherine Bruce, Hosam Shams-Eldin, Paul Denny, Sabrina Sonda, John Mina, Josefina Casas, Kentaro Hanada, Ralph T. Schwarz   +9 more
core   +1 more source