Results 31 to 40 of about 65,062 (302)

Disruption of Intracellular Calcium Homeostasis as a Therapeutic Target Against Trypanosoma cruzi

Frontiers in Cellular and Infection Microbiology, 2020
There is no effective cure for Chagas disease, which is caused by infection with the arthropod-borne parasite, Trypanosoma cruzi. In the search for new drugs to treat Chagas disease, potential therapeutic targets have been identified by exploiting the ...
Gustavo Benaim, Gustavo Benaim, Alberto E. Paniz-Mondolfi, Alberto E. Paniz-Mondolfi, Emilia Mia Sordillo, Emilia Mia Sordillo, Nathalia Martinez-Sotillo   +6 more
doaj   +1 more source

Mechanisms of cellular invasion by intracellular parasites [PDF]

Cellular and Molecular Life Sciences, 2013
Numerous disease-causing parasites must invade host cells in order to prosper. Collectively, such pathogens are responsible for a staggering amount of human sickness and death throughout the world. Leishmaniasis, Chagas disease, toxoplasmosis, and malaria are neglected diseases and therefore are linked to socio-economical and geographical factors ...
Dawn M, Walker, Steve, Oghumu, Gaurav, Gupta, Bradford S, McGwire, Mark E, Drew, Abhay R, Satoskar   +5 more
openaire   +2 more sources

Malarial proteases and host cell egress: an 'emerging' cascade. [PDF]

, 2008
Malaria is a scourge of large swathes of the globe, stressing the need for a continuing effort to better understand the biology of its aetiological agent. Like all pathogens of the phylum Apicomplexa, the malaria parasite spends part of its life inside a
Blackman, Michael J
core   +1 more source

Extracellular vesicles could be a putative posttranscriptional regulatory mechanism that shapes intracellular RNA levels in Plasmodium falciparum

Nature Communications, 2023
Plasmodium falciparum secretes extracellular vesicles (PfEVs) that contain parasite-derived RNA. However, the significance of the secreted RNA remains unexplored. Here, we compare secreted and intracellular RNA from asexual cultures of six P.
Mwikali Kioko, Alena Pance, Shaban Mwangi, David Goulding, Alison Kemp, Martin Rono, Lynette Isabella Ochola-Oyier, Pete C. Bull, Philip Bejon, Julian C. Rayner, Abdirahman I. Abdi   +10 more
doaj   +1 more source

IL-10 from CD4(+)CD25(-)Foxp3(-)CD127(-) adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection [PDF]

, 2008
The outcome of malaria infection is determined, in part, by the balance of pro-inflammatory and regulatory immune responses. Failure to develop an effective pro-inflammatory response can lead to unrestricted parasite replication, whilst failure to ...
Couper, Kevin N, Hafalla, Julius C, Riley, Eleanor M, Daniel G. Blount, Eleanor M Riley, Blount, Daniel G., Kevin N Couper, Richard A Flavell, Wilson, MS, de Souza, J Brian, Daniel G Blount, Mark S Wilson, Couper, KN, Blount, DG, Kamanaka, Masahito, Wilson, Mark S, Julius C. Hafalla, Belkaid, Yasmine, Masahito Kamanaka, Blount, Daniel G, Flavell, Richard A, Flavell, Richard A., J. Brian de Souza, Flavell, RA, De Souza, J. Brian, Kevin N. Couper, Kamanaka, M, Hafalla, Julius C., Julius C Hafalla, Eleanor M. Riley, Hafalla, JC, Riley, Eleanor M., Belkaid, Y, Yasmine Belkaid, De Souza, JB, Mark S. Wilson, Richard A. Flavell, Couper, Kevin N., Wilson, Mark S., Riley, EM, J Brian de Souza   +40 more
core   +1 more source

Phosphoinositide metabolism links cGMP-dependent protein kinase G to essential Ca²⁺ signals at key decision points in the life cycle of malaria parasites [PDF]

, 2014
This work was funded by grants from the Wellcome Trust (WT098051 and 079643/Z/06/Z) and the Medical Research Council (G0501670) to OB, a Wellcome Trust project grant to DB (WT094752), a Wellcome Trust Grant (WT093228) to TKS, a Marie Curie Fellowship ...
Katrin Volkmann, Chappell, Lia, Brochet, M., Oliver Billker, Eloise Thompson, Billker, Oliver,, Mathieu Brochet, Berriman, Matthew, Jyoti Choudhary (261900), Frank Schwach, Rayner, Julian C., Rayner, Julian C, Jyoti Choudhary, Lia Chappell (530631), Sebastian, Sarah, Lia Chappell, Chappell, L., Terry K. Smith (112550), Gomes, Ana Rita, Frank Schwach (530630), Ana Rita Gomes, Oliver Billker (92636), Smith, T.K., Thompson, E., Schwach, F., Sebastian, S., Baker, David A, Volkmann, K., Sarah Sebastian (530629), Volkmann, Katrin, David A Baker, Terry K Smith, Ana Rita Gomes (220735), Collins, Mark O., Smith, Terry K., Mark O Collins, Gomes, A.R., Collins, M.O., David A. Baker (122252), Choudhary, J., Julian C Rayner, Brochet, Mathieu, Mathieu Brochet (149272), Billker, Oliver, Collins, Mark O, Mark O. Collins (131229), Billker, O., Schwach, Frank, Berriman, M., Sarah Sebastian, Rayner, J.C., Matthew Berriman (5353), Baker, David A., Thompson, Eloise, Smith, Terry K, Matthew Berriman, Choudhary, Jyoti, Eloise Thompson (376344), Baker, D.A., Julian C. Rayner (121198), Katrin Volkmann (149256)   +60 more
core   +1 more source

Protein kinase TgCDPK7 regulates vesicular trafficking and phospholipid synthesis in Toxoplasma gondii.

PLoS Pathogens, 2021
Apicomplexan parasites are causative agents of major human diseases. Calcium Dependent Protein Kinases (CDPKs) are crucial components for the intracellular development of apicomplexan parasites and are thus considered attractive drug targets. CDPK7 is an
Priyanka Bansal, Neelam Antil, Manish Kumar, Yoshiki Yamaryo-Botté, Rahul Singh Rawat, Sneha Pinto, Keshava K Datta, Nicholas J Katris, Cyrille Y Botté, T S Keshava Prasad, Pushkar Sharma   +10 more
doaj   +1 more source

Functional analysis of leishmania cyclopropane fatty acid synthetase [PDF]

, 2012
The single gene encoding cyclopropane fatty acid synthetase (CFAS) is present in Leishmania infantum, L. mexicana and L. braziliensis but absent from L. major, a causative agent of cutaneous leishmaniasis. In L.
Mottram Jeremy C., Evans, K.J., Samuel O. Oyola (112546), Barbara A. Smith (112553), Smith, Barbara A., Terry K Smith, Smith Barbara A., Samuel O Oyola, Smith, Deborah F., Paul M Kaye, James D. Hilley (112558), Kaye, Paul M., Evans, Krystal J., Smith, Terry K., Smith, B.A., Oyola, Samuel O., Hilley, J.D., Mottram, J.C., Kaye, P.M., Oyola, S.O., Jeremy C. Mottram (112563), Smith Terry K., Terry K. Smith (112550), Smith, D.F., Mottram, Jeremy C., Hilley James D., Oyola Samuel O., Paul M. Kaye (54054), Deborah F. Smith (112029), Krystal J Evans, Evans Krystal J., Jeremy C Mottram, Kaye Paul M., James D Hilley, Smith, T.K., Barbara A Smith, Krystal J. Evans (112547), Smith Deborah F., Deborah F Smith, Hilley, James D.   +39 more
core   +1 more source

Identification of Fis1 Interactors in Toxoplasma gondii Reveals a Novel Protein Required for Peripheral Distribution of the Mitochondrion

mBio, 2020
Toxoplasma gondii’s single mitochondrion is very dynamic and undergoes morphological changes throughout the parasite’s life cycle. During parasite division, the mitochondrion elongates, enters the daughter cells just prior to cytokinesis, and undergoes ...
Kylie Jacobs, Robert Charvat, Gustavo Arrizabalaga   +2 more
doaj   +1 more source

Phosphatidylserine synthase in the endoplasmic reticulum of Toxoplasma is essential for its lytic cycle in human cells

Journal of Lipid Research
Glycerophospholipids have emerged as a significant contributor to the intracellular growth of pathogenic protist Toxoplasma gondii. Phosphatidylserine (PtdSer) is one such lipid, attributed to the locomotion and motility-dependent invasion and egress ...
Dimitrios Alexandros Katelas, Rosalba Cruz-Miron, Ruben D. Arroyo-Olarte, Jos F. Brouwers, Ratnesh Kumar Srivastav, Nishith Gupta   +5 more
doaj   +1 more source