Results 41 to 50 of about 65,062 (302)

Within-Host Dynamics of Multi-Species Infections:Facilitation, Competition and Virulence [PDF]

, 2012
Host individuals are often infected with more than one parasite species (parasites defined broadly, to include viruses and bacteria). Yet, research in infection biology is dominated by studies on single-parasite infections.
Eswarappa, Sandeepa M., Sylvie Estrela, Sam P Brown, Sylvie Estrela (156401), Estrela, Sylvie, Sam P. Brown (30600), Brown, Sam P., Sandeepa M Eswarappa, Sandeepa M. Eswarappa (156396)   +8 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The motility of a human parasite, Toxoplasma gondii, is regulated by a novel lysine methyltransferase. [PDF]

PLoS Pathogens, 2011
Protozoa in the phylum Apicomplexa are a large group of obligate intracellular parasites. Toxoplasma gondii and other apicomplexan parasites, such as Plasmodium falciparum, cause diseases by reiterating their lytic cycle, comprising host cell invasion ...
Aoife T Heaslip, Manami Nishi, Barry Stein, Ke Hu   +3 more
doaj   +1 more source

Actin-mediated plasma membrane plasticity of the intracellular parasite Theileria annulata

, 2012
Pathogen–host interactions are modulated at multiple levels by both the pathogen and the host cell. Modulation of host cell functions is particularly intriguing in the case of the intracellular T heileria parasite, which resides as a multinucleated ...
Cyrklaff, Marek, Stoffel, Michael, Kühni-Boghenbor, Kathrin, Frischknecht, Friedrich, Gaschen, Véronique, Baumgartner, Martin, Ma, Min, Lemgruber, Leandro, Stoffel, Michael Hubert, Lemgruber Soares, Leandro   +9 more
core   +1 more source

The genome of the obligate intracellular parasite Trachipleistophora hominis : new insights into microsporidian genome dynamics and reductive evolution [PDF]

, 2012
The dynamics of reductive genome evolution for eukaryotes living inside other eukaryotic cells are poorly understood compared to well-studied model systems involving obligate intracellular bacteria.
Thomas Weinmaier (124598), Hall, Neil (Department of Functional and Comparative Genomics, School of Biological Sciences, University of Liverpool), Bernhardt Jörg, Robert P Hirt, Hacker Christian, Swan, Daniel C., Robert P. Hirt (124609), Weinmaier, Thomas, Nakjang, Sirintra, Rattei, Thomas, Harris, Simon R. (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Noël Christophe J., Noel, Christophe J., Embley, T. Martin, John M. Lucocq (124603), Christian Hacker (124601), Hirt, Robert P. (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Christophe J. Noël (124592), Lucocq, John M., Stephanie Markert, Tom A. Williams, Embley T. Martin, Neil Hall, Nakjang Sirintra, Williams Tom A., Sirintra Nakjang (124590), Dagan Tal, Martin Embley, John M Lucocq, Rattei, Thomas (University of Vienna), Goldberg Alina V., Tom A Williams, Dagan, Tal (Institute for Molecular Evolution, Heinrich Heine University Düsseldorf), Lucocq John M., Hall Neil, Bernhardt, Jörg, Heinz Eva, Simon R. Harris, Neil Hall (12782), Lucocq, John M. (School of Medicine, University of St Andrews), Noël, Christophe J. (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Weinmaier, Thomas (University of Vienna), Markert, Stephanie (Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald), Tal Dagan, Daniel C. Swan, Sirintra Nakjang, John M. Lucocq, Dörte Becher, Rattei Thomas, Harris Simon R., Daniel C Swan, Christian Hacker, Thomas Rattei (13991), Becher, Dörte, Swan Daniel C., Heinz, Eva (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Weinmaier Thomas, Eva Heinz, Hacker, Christian, Alina V. Goldberg, Simon R Harris, Christophe J. Noël, Thomas Rattei, Eva Heinz (105025), Swan, Daniel C. (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Thomas Weinmaier, Simon R. Harris (124597), Schweder, Thomas (Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald), T Martin Embley, Becher, Doerte, Harris, Simon R., Hacker, Christian (School of Medicine, University of St Andrews), Alina V. Goldberg (124596), Heinz, Eva, Dagan, Tal, Becher Dörte, Markert, Stephanie, Bernhardt, Jörg (Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald), Goldberg, Alina V. (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Schweder Thomas, Hirt, Robert P., T. Martin Embley (124611), Nakjang, Sirintra (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Dörte Becher (90765), Tom A. Williams (124587), Thomas Schweder (124606), Markert Stephanie, Bernhardt, Joerg, Embley, T. Martin (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Williams, Tom A., Hirt Robert P., Alina V Goldberg, Williams, Tom A. (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Jörg Bernhardt (124600), Jörg Bernhardt, Goldberg, Alina V., Schweder, Thomas, Tal Dagan (68513), Robert P. Hirt, Lucocq, John Milton, Hall, Neil, Christophe J Noël, Thomas Schweder, Becher, Dörte (Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald), Daniel C. Swan (124594), Stephanie Markert (124599)   +105 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Control of parasitophorous vacuole expansion by LYST/Beige restricts the intracellular growth of Leishmania amazonensis. [PDF]

PLoS Pathogens, 2008
The intracellular protozoan Leishmania replicates in parasitophorous vacuoles (PV) that share many features with late endosomes/lysosomes. L. amazonensis PVs expand markedly during infections, but the impact of PV size on parasite intracellular survival ...
Jude Wilson, Chau Huynh, Kathleen A Kennedy, Diane M Ward, Jerry Kaplan, Alan Aderem, Norma W Andrews   +6 more
doaj   +1 more source

Draft genome sequence of the Daphnia pathogen Octosporea bayeri: insights into the gene content of a large microsporidian genome and a model for host-parasite interactions [PDF]

, 2009
Background: The highly compacted 2.9-Mb genome of Encephalitozoon cuniculi placed the microsporidia in the spotlight, encoding a mere 2,000 proteins and a highly reduced suite of biochemical pathways.
Ebert, Dieter, Corradi, N., Pombert, J. F., Haag, Karen L., Keeling, P. J., Haag, Karen Luisa, Haag, K. L., Pombert, Jean-François, Corradi, Nicolas, Keeling, Patrick J., Keeling, Patrick J. (Patrick John), 1969-   +10 more
core   +1 more source

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

Sarcoendoplasmic reticulum calcium ATPase is an essential and druggable lipid-dependent ion pump in Toxoplasma gondii

Communications Biology
Toxoplasma gondii is a common intracellular pathogenic protist causing acute and chronic infections in many warm-blooded organisms. Calcium homeostasis is pivotal for its asexual reproduction in mammalian host cells, and sarcoendoplasmic reticulum ...
Rosalba Cruz-Mirón, Namita Pandey, Dimitrios Alexandros Katelas, Arunakar Kuchipudi, Dharmarajan Sriram, Aditi Gangopadhyay, Soumyananda Chakraborti, Ratnesh Kumar Srivastav, Nishith Gupta   +8 more
doaj   +1 more source