Results 141 to 150 of about 281,844 (353)

Modelling the dynamics of intramammary E. coli infections in dairy cows: understanding mechanisms that distinguish transient from persistent infections [PDF]

, 2009
The majority of intramammary infections with Escherichia coli in dairy cows result in transient infections with duration of about 10 days or less, although more persistent infections (2 months or longer) have been identified.
Green, L, Döpfer, D, Medley, GF, Laura Green, Graham F. Medley, Medley, Graham F., Belgin Dogan, Lisa J. White, White, Lisa, Chappell, M. J. (Michael J.), Dogan, B, Green, Laura, Chappell, Mike J., Ynte H. Schukken, White, Lisa J., Schukken, Ynte H., Chappell, MJ, Dogan, Belgin, Schukken, Y. H., Schukken, YH, White, L. J., Mike J. Chappell, Dörte Döpfer, Medley, Graham, Green, Laura E., White, LJ, Green, Laura; id_orcid, Döpfer, Dörte   +27 more
core   +1 more source

Cellular Imaging of Intracellular Bacterial Pathogens

Microbiology Spectrum, 2019
ABSTRACT The spatial dimensions of host cells and bacterial microbes are perfectly suited to being studied by microscopy techniques. Therefore, cellular imaging has been instrumental in uncovering many paradigms of the intracellular lifestyle of microbes. Initially, microscopy was used as a qualitative, descriptive tool.
Stévenin, Virginie, Enninga, Jost
openaire   +2 more sources

A Surface‐engineered Microfluidic Device for Antibody‐Mediated Negative Selection of High‐Quality Sperm for Assisted Reproduction

Advanced Functional Materials, EarlyView.
This study reports a microfluidic device with a functionalized surface utilizing a polyoxazoline coating and covalently immobilized gold nanoparticles and anti‐phosphatidylserine antibody. The device efficiently eliminates pre‐apoptotic and apoptotic spermatozoa and yields sperm with substantially improved quality and low DNA damage, offering a simple ...
Soraya Rasi Ghaemi, David J. Sharkey, Nicole O. McPherson, Markos Negash Alemie, Krasimir Vasilev, Sarah A. Robertson   +5 more
wiley   +1 more source

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

Applying RNA-Seq to investigate the transition into a Viable But Non Culturable State (VBNC) for the intracellular pathogen, Francisella tularensis LVS.

, 2023
Stuart Cantlay, Nicole L. Garrison, Rachelle Patterson, Donald A. Primerano, Jun Fan, Joseph Horzempa   +5 more
openalex   +2 more sources

Glutathione activates virulence gene expression of an intracellular pathogen

, 2015
Intracellular pathogens are responsible for much of the world-wide morbidity and mortality due to infectious diseases. To colonize their hosts successfully, pathogens must sense their environment and regulate virulence gene expression appropriately ...
Brennan, Richard G, Daniel A. Portnoy, Hamilton, Keri L, Portnoy, Daniel A, Aaron T. Whiteley, Sonya M. John, Peter Lauer, Reniere, Michelle L, Richard G. Brennan, John, Sonya M, Lauer, Peter, Whiteley, Aaron T, Michelle L. Reniere, Keri L. Hamilton   +13 more
core   +1 more source

A sensor histidine kinase from a plant-endosymbiont bacterium restores the virulence of a mammalian intracellular pathogen. [PDF]

Microb Pathog, 2023
Chaves-Olarte E, Meza-Torres J, Herrera-Rodríguez F, Lizano-González E, Suárez-Esquivel M, Baker KS, Rivas-Solano O, Ruiz-Villalobos N, Villalta-Romero F, Cheng HP, Walker GC, Cloeckaert A, Thomson NR, Frisan T, Moreno E, Guzmán-Verri C.   +15 more
europepmc   +1 more source

Ligand induced cleavage and nuclear localization of the rice XA21 immune receptor

, 2012
The rice XA21 receptor confers immunity to the Gram-negative bacterial pathogen, _Xanthomonas oryzae_ pv. _oryzae_ (_Xoo_) upon recognition of the conserved microbial signature AxY^S^22.
Chang-Jin Park, Pamela C. Ronald
core  

Salmonella enterica Serovar Typhimurium Response Involved in Attenuation of Pathogen Intracellular Proliferation

, 2001
Salmonella enterica serovar Typhimurium proliferates within cultured epithelial and macrophage cells. Intracellular bacterial proliferation is, however, restricted within normal fibroblast cells.
David A. Cano, Francisco Garcı́a-Del Portillo, Marina Martı́nez-Moya, Josep Casadesús, Eduardo A. Groisman, M. Graciela Pucciarelli   +5 more
core   +1 more source

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source