Results 121 to 130 of about 281,844 (353)

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Internally controlled real-time PCR method for quantitative species-specific detection and vapA genotyping of Rhodococcus equi

, 2006
We developed a novel quantitative real-time PCR (Q-PCR) method for the soil actinomycete Rhodococcus equi, an important horse pathogen and emerging human pathogen.
Makrai, L, D. A. Lewis, Rodríguez-Lázaro, AD, Scortti, MM, Rodríguez-Lázaro, David, Hernandez, Marta, Lewis, DA, Vazquez-Boland, Jose A, M. Hernandez, J. A. Vazquez-Boland, Makrai, Laszlo, U. Fogarty, Scortti, Mariela, Hernández, M, Navas, Jesus, Ocampo-Sosa, A, Vázquez-Boland, JA, J. Navas, Ocampo-Sosa, Alain A, Lewis, Deborah A, Fogarty, U, Fogarty, Ursula, M. Scortti, A. A. Ocampo-Sosa, L. Makrai, Navas, J, D. Rodriguez-Lazaro   +26 more
core   +1 more source

Approaching the secrets of N-glycosylation in Aspergillus fumigatus [PDF]

, 2010
The mannosyltransferase Och1 is the key enzyme for synthesis of elaborated protein N-glycans in yeast. In filamentous fungi genes implicated in outer chain formation are present, but their function is unclear.
Engel Jakob, Echtenacher, Bernd, Bernd Echtenacher, Ilse Jacobsen, Kotz, Andrea, Routier Françoise H., Wagener, Johannes, Routier, Françoise H., Engel, Jakob, Kotz Andrea, Ebel Frank, Frank Ebel, Jacobsen Ilse, Françoise H Routier, Wagener Johannes, Heesemann, Jürgen, Johannes Wagener, Nielsen, Kirsten, Echtenacher Bernd, Jakob Engel, Ebel, Frank, Jürgen Heesemann, Heesemann Jürgen, Andrea Kotz, Françoise H. Routier, Jacobsen, Ilse   +25 more
core   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

3D reconstructions of parasite development and the intracellular niche of the microsporidian pathogen E. intestinalis [PDF]

, 2023
Noelle V. Antao, Miu-Ling Lam, А. В. Давыдов, Margot Riggi, Joseph Sall, Christopher J. Petzold, Feng‐Xia Liang, Janet Iwasa, Damian C. Ekiert, Gira Bhabha   +9 more
openalex   +1 more source

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Microarray analysis of defined Mycobacterium tuberculosis populations using RNA amplification strategies. [PDF]

, 2008
BACKGROUND: The amplification of bacterial RNA is required if complex host-pathogen interactions are to be studied where the recovery of bacterial RNA is limited.
Laing Ken, Waddell, SJ, Butcher, PD, Senner Claire, Simon Waddell (4462816), Ken Laing, Laing, K, Ken Laing (173955), Philip D Butcher, Waddell Simon J, Butcher Philip D, Claire Senner (44405), Simon J Waddell, Claire Senner, Senner, C, Philip D Butcher (16047203)   +15 more
core   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Dual RNA-seq of Orientia tsutsugamushi informs on host-pathogen interactions for this neglected intracellular human pathogen.

, 2020
Studying emerging or neglected pathogens is often challenging due to insufficient information and absence of genetic tools. Dual RNA-seq provides insights into host-pathogen interactions, and is particularly informative for intracellular organisms.
Salje, Jeanne, Alexander J. Westermann, Willow Kion-Crosby, Vogel, Jörg, Lars Barquist, Sobota, Radoslaw M, Selvakumar Subbian, Chuenklin, Suthida, Radoslaw M. Sobota, Westermann, Alexander J, Jeanne Salje, Suparat Giengkam, Wang, Loo Chien, Mika-Gospodorz, Bozena, Jörg Vogel, Kion-Crosby, Willow, Sunyakumthorn, Piyanate, Barquist, Lars, Piyanate Sunyakumthorn, Bozena Mika-Gospodorz, Loo Chien Wang, Wongsantichon, Jantana, Jantana Wongsantichon, Giengkam, Suparat, Subbian, Selvakumar, Suthida Chuenklin   +25 more
core   +1 more source