Results 121 to 130 of about 1,012,172 (301)
Orientia tsutsugamushi: A neglected but fascinating obligate intracellular bacterial pathogen. [PDF]
, 2017 Our understanding of the molecular systems that bacteria have developed over millennia of evolutionary tinkering remains limited compared with the incredible diversity of the bacterial kingdom.
Salje, J, Salje, Jeanne, Jeanne Salje
core +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini +12 more
wiley +1 more source
Draft genome sequence of the Daphnia pathogen Octosporea bayeri: insights into the gene content of a large microsporidian genome and a model for host-parasite interactions [PDF]
, 2009 Background: The highly compacted 2.9-Mb genome of Encephalitozoon cuniculi placed the microsporidia in the spotlight, encoding a mere 2,000 proteins and a highly reduced suite of biochemical pathways.
Ebert, Dieter +10 more
core +1 more source
Biomolecular Concepts, 2012 Effective vaccination against intracellular pathogens, such as tuberculosis (TB), relies on the generation and maintenance of CD4 memory T cells. An incomplete understanding of the memory immune response has hindered the rational design of a new, more ...
Ancelet Lindsay, Kirman Joanna
doaj +1 more source
mBio, 2018 Francisella tularensis is a Gram-negative, facultative, intracellular bacterial pathogen and one of the most virulent organisms known. A hallmark of F. tularensis pathogenesis is the bacterium’s ability to replicate to high densities within the cytoplasm
Lauren C. Radlinski +4 more
doaj +1 more source
Human genetic susceptibility to intracellular pathogens
Immunological Reviews, 2011 Summary: Intracellular pathogens contribute to a significant proportion of infectious disease morbidity and mortality worldwide. Increasing evidence points to a major role for host genetics in explaining inter‐individual variation in susceptibility to infectious diseases.
Vannberg, F, Chapman, S, Hill, A
openaire +3 more sources
Progressive Parkinsonism in PPP2R5D‐Related Neurodevelopmental Disorder
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT PPP2R5D‐related neurodevelopmental disorder (Houge–Janssens syndrome type 1) is a rare autosomal dominant condition characterized by macrocephaly, intellectual disability, and epilepsy. Progressive parkinsonism is an emerging adult phenotype that neurologists should be aware of since timely genetic diagnosis opens the door to disease‐modifying
Katerina Bernardi +6 more
wiley +1 more source
Brucella abortus histidine auxotrophs are copper sensitive
Journal of BacteriologyDespite decades of investigation into bacterial pathogens, the conditions met by intracellular bacteria are still unclear. These conditions can include access to nutrients, such as amino acids, and exposure to toxic compounds, like copper. To investigate
Charline Focant +4 more
doaj +1 more source
The complex amino acid diet of Francisella in infected macrophages
Frontiers in Cellular and Infection Microbiology, 2015 Francisella tularensis, the agent of the zoonotic disease tularemia, is a highly infectious bacterium for a large number of animal species and can be transmitted to humans by various means.
Alain eCharbit
doaj +1 more source
A sensor histidine kinase from a plant-endosymbiont bacterium restores the virulence of a mammalian intracellular pathogen. [PDF]
Microb Pathog, 2023 Chaves-Olarte E +15 more
europepmc +1 more source