Results 101 to 110 of about 281,844 (353)

Harnessing Macrophages for Controlled-Release Drug Delivery: Lessons From Microbes

Frontiers in Pharmacology, 2019
With the effectiveness of therapeutic agents ever decreasing and the increased incidence of multi-drug resistant pathogens, there is a clear need for administration of more potent, potentially more toxic, drugs. Alternatively, biopharmaceuticals may hold
Johan Georg Visser, Anton Du Preez Van Staden, Carine Smith   +2 more
doaj   +1 more source

A zebrafish model for Chlamydia infection with the obligate intracellular pathogen Waddlia chondrophila [PDF]

, 2016
Obligate intracellular chlamydial bacteria of the Planctomycetes-Verrucomicrobia-Chlamydiae (PVC) superphylum are important pathogens of terrestrial and marine vertebrates, yet many features of their pathogenesis and host specificity are still unknown ...
Lehner, Angelika, Angelika Lehner, Ruetten, M, Helena M. B. Seth-Smith, Lloyd Vaughan, Stephan C. F. Neuhauss, Neuhauss, Stephan C F, Ruetten, Maja, Voegtlin, A, Neuhauss, S C F; https://orcid.org/, Maja Ruetten, Seth-Smith, Helena M B, Gilbert Greub, Philip S. Crosier, Fehr, Alexander G J, Nufer, Lisbeth, Lisbeth Nufer, Greub, Gilbert, Crosier, Philip S, Alexander G. J. Fehr, Andrea Voegtlin, Vaughan, Lloyd, Vögtlin, Andrea   +22 more
core   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Draft genome sequence of the Daphnia pathogen Octosporea bayeri: insights into the gene content of a large microsporidian genome and a model for host-parasite interactions [PDF]

, 2009
Background: The highly compacted 2.9-Mb genome of Encephalitozoon cuniculi placed the microsporidia in the spotlight, encoding a mere 2,000 proteins and a highly reduced suite of biochemical pathways.
Ebert, Dieter, Corradi, N., Pombert, J. F., Haag, Karen L., Keeling, P. J., Haag, Karen Luisa, Haag, K. L., Pombert, Jean-François, Corradi, Nicolas, Keeling, Patrick J., Keeling, Patrick J. (Patrick John), 1969-   +10 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Rab32 restriction of intracellular bacterial pathogens [PDF]

Small GTPases, 2016
Our immune system is engaged in a continuous battle against invading pathogens, many of which have evolved to survive in intracellular niches of mammalian hosts. A variety of cellular processes are involved in preventing bacterial invasion or in killing bacteria that successfully invade host cells.
Solano-Collado, Virtu, Rofe, Adam, Spano, Stefania   +2 more
openaire   +3 more sources

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Lipid Droplet, a Key Player in Host-Parasite Interactions

Frontiers in Immunology, 2018
Lipid droplets (lipid bodies, LDs) are dynamic organelles that have important roles in regulating lipid metabolism, energy homeostasis, cell signaling, membrane trafficking, and inflammation. LD biogenesis, composition, and functions are highly regulated
Adriana Lima Vallochi, Livia Teixeira, Karina da Silva Oliveira, Clarissa Menezes Maya-Monteiro, Patricia T. Bozza   +4 more
doaj   +1 more source

Transcriptional adaptation of shigella flexneri during infection of macrophages and epithelial cells : insights into the strategies of a cytosolic bacterial pathogen

, 2004
Shigella flexneri, the etiologic agent of bacillary dysentery, invades epithelial cells as well as macrophages and dendritic cells and escapes into the cytosol soon after invasion.
Hong Liu, Lucchini, Sacha, Qi, J., Sacha Lucchini, S. Lucchini, Jin, Qi, Hinton, Jay C. D., Qi Jin, H. Liu, Liu, Hong, J. C. D. Hinton, Lucchini, S., Hinton, J.C.D., Jay C. D. Hinton, Yu, J., Jun Yu, J. Yu, Liu, H., Q. Jin, Yu, Jun   +19 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source