Results 81 to 90 of about 281,844 (353)

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Processing of chlamydia abortus polymorphic membrane protein 18D during the chlamydial developmental cycle [PDF]

, 2012
<p>Background: Chlamydia possess a unique family of autotransporter proteins known as the Polymorphic membrane proteins (Pmps). While the total number of pmp genes varies between Chlamydia species, all encode a single pmpD gene.
Smith, David George Emslie, Michelle Sait (122019), Longbottom, D., David G E Smith, David G. E. Smith, Aitchison, Kevin, Neil F. Inglis (122039), Wheelhouse, NM, Sait, M, Longbottom, D, Livingstone, M., Nick M. Wheelhouse (122015), McLean, K., McLean, Kevin, Wright, F., Morag Livingstone, Aitchison, K., Frank Wright (122030), Wright, F, Michelle Sait, Neil F. Inglis, Kevin McLean (122035), Wright, Frank, Livingstone, Morag, Smith, David G E, Wheelhouse, Nick M, Smith, DGE, Wheelhouse, N.M., Nick M Wheelhouse, Morag Livingstone (122027), Inglis, N.F., David Longbottom, Longbottom, David, Neil F Inglis, Wheelhouse, Nick M., Inglis, Neil F, David Longbottom (122043), Kevin Aitchison (122024), Livingstone, M, Aitchison, K, Inglis, NF, Frank Wright, Sait, M., Kevin McLean, Nick M. Wheelhouse, David G. E. Smith (122041), Sait, Michelle, Inglis, Neil F., Kevin Aitchison, McLean, K, Smith, D.G.E.   +50 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Influential Parameters for the Analysis of Intracellular Parasite Metabolomics

mSphere, 2018
Metabolomics is increasingly popular for the study of pathogens. For the malaria parasite Plasmodium falciparum, both targeted and untargeted metabolomics have improved our understanding of pathogenesis, host-parasite interactions, and antimalarial drug ...
Maureen A. Carey, Vincent Covelli, Audrey Brown, Gregory L. Medlock, Mareike Haaren, Jessica G. Cooper, Jason A. Papin, Jennifer L. Guler   +7 more
doaj   +1 more source

A systems biological view of intracellular pathogens [PDF]

Immunological Reviews, 2011
Summary:  As biomedical research becomes increasingly data‐intensive, it is increasingly essential to integrate genomic‐scale datasets, so as to generate a more holistic picture of complex biological processes. The systems biology paradigm may differ in strategy from traditional reductionist scientific methods, but the goal remains the same: to ...
Daniel P, Beiting, David S, Roos
openaire   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Effect of Bacteriophage on the Transcriptional and Translational Expression of Inflammatory Mediators in Chicken Macrophage

The Journal of Poultry Science, 2014
This study was designed to evaluate the effect of bacteriophage on macrophage-mediated inflammatory immune responses against intracellular pathogens.
Juhee Ahn, Song-rae Kim, Lae-Seung Jung, Debabrata Biswas   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Acute bee paralysis virus regulation of microRNA expression dynamics in the insect host (Apis mellifera) cell line, AmE-711

Frontiers in Cellular and Infection Microbiology
BackgroundHoney bees (Apis mellifera) are essential pollinators that support global food production and economic stability. Their health and survival are threatened by diminishing floral resources, pesticide exposure, parasitic mites, and microbial and ...
Deepak Kumar, Michael Goblirsch, John Adamczyk, Shahid Karim   +3 more
doaj   +1 more source

Structural characterisation of the virulence-associated protein VapG from the horse pathogen Rhodococcus equi

, 2015
Virulence and host range in Rhodococcus equi depends on the variable pathogenicity island of their virulence plasmids. Notable gene products are a family of small secreted virulence-associated proteins (Vaps) that are critical to intramacrophagic ...
Blagova, Elena V., Okoko, Tebekeme, Dover, Lynn, Wilkinson, Anthony, Dover, Lynn G., Blagova, Elena, Whittingham, Jean L., Whittingham, Jean, Wilkinson, Anthony J.   +8 more
core   +1 more source