Results 81 to 90 of about 1,064,501 (255)

Interplay of host–pathogen microvesicles and their role in infectious disease

, 2013
The release of extracellular vesicles, whether MVs (microvesicles) or exosomes, from host cells or intracellular pathogens is likely to play a significant role in the infection process.
Lange, S., Ansa-Addo, E.A., Inal, J.M.
core   +1 more source

Dual RNA-seq of Orientia tsutsugamushi informs on host-pathogen interactions for this neglected intracellular human pathogen. [PDF]

, 2020
Studying emerging or neglected pathogens is often challenging due to insufficient information and absence of genetic tools. Dual RNA-seq provides insights into host-pathogen interactions, and is particularly informative for intracellular organisms.
Salje, Jeanne, Alexander J. Westermann, Willow Kion-Crosby, Vogel, Jörg, Lars Barquist, Sobota, Radoslaw M, Selvakumar Subbian, Chuenklin, Suthida, Radoslaw M. Sobota, Westermann, Alexander J, Jeanne Salje, Suparat Giengkam, Wang, Loo Chien, Mika-Gospodorz, Bozena, Jörg Vogel, Kion-Crosby, Willow, Sunyakumthorn, Piyanate, Barquist, Lars, Piyanate Sunyakumthorn, Bozena Mika-Gospodorz, Loo Chien Wang, Wongsantichon, Jantana, Jantana Wongsantichon, Giengkam, Suparat, Subbian, Selvakumar, Suthida Chuenklin   +25 more
core   +2 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Metabolic modeling with reverse mapping links host perturbations to

iScience
Summary: Understanding host-pathogen interactions during Mycobacterium tuberculosis (Mtb) infection has largely relied on identifying bacterial genes essential for intracellular survival.
Jayendrajyoti Kundu, Vishawjeet Barik, Abhijit Paul, Ankit Biswas, Pallavi Mudgal, Yashwant Kumar, Tushar Kanti Maiti, Amit Kumar Pandey, Samrat Chatterjee   +8 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

A novel rapid host cell entry pathway determines the intracellular fate of Staphylococcus aureus

eLife
Staphylococcus aureus is an opportunistic pathogen causing severe diseases. Recently, S. aureus was recognized as an intracellular pathogen, whereby the intracellular niche promotes immune evasion and antibiotic resistance. Interaction of S.
Marcel Rühling, Fabio Schmelz, Kim Ulbrich, Fabian Schumacher, Julia Wolf, Maximilian Pfefferle, Magdalena Priester, Adriana Moldovan, Nadine Knoch, Andreas Iwanowitsch, Christian Kappe, Kerstin Paprotka, Burkhard Kleuser, Christoph Arenz, Martin J Fraunholz   +14 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Lipid Droplet, a Key Player in Host-Parasite Interactions

Frontiers in Immunology, 2018
Lipid droplets (lipid bodies, LDs) are dynamic organelles that have important roles in regulating lipid metabolism, energy homeostasis, cell signaling, membrane trafficking, and inflammation. LD biogenesis, composition, and functions are highly regulated
Adriana Lima Vallochi, Livia Teixeira, Karina da Silva Oliveira, Clarissa Menezes Maya-Monteiro, Patricia T. Bozza   +4 more
doaj   +1 more source

Intracellular pathogen targeting by IL32 elicits cell-autonomous immunity

Interferon gamma safeguards humans against intracellular pathogens, yet how most interferon-stimulated genes protect host cells, and how human-adapted pathogens evade these defenses is unclear.
Emma A Johnston, Jorn Coers, Isabelle Derre, Robert Suchland, So Young Kim, Kevin Hybiske, Maria E Cortina, Haley Adcox, Neal Alto, Jeffrey R Reitano, Stephen C Walsh, Mary S Dickinson   +11 more
core   +1 more source