Results 71 to 80 of about 281,844 (353)

Chlamydia trachomatis modulates the expression of JAK-STAT signaling components to attenuate the type II interferon response of epithelial cells

mBio
Chlamydia trachomatis has adapted to subvert signaling in epithelial cells to ensure successful intracellular development. Interferon-γ (IFNγ) produced by recruited lymphocytes signals through the JAK/STAT pathway to restrict chlamydial growth in the ...
Francis L. Fontanilla, Joyce A. Ibana, Rey A. Carabeo, Amanda J. Brinkworth   +3 more
doaj   +1 more source

Salmonella enterica Infections Are Disrupted by Two Small Molecules That Accumulate within Phagosomes and Differentially Damage Bacterial Inner Membranes

mBio, 2022
Gram-negative bacteria have a robust cell envelope that excludes or expels many antimicrobial agents. However, during infection, host soluble innate immune factors permeabilize the bacterial outer membrane.
Joseph A. Villanueva, Amy L. Crooks, Toni A. Nagy, Joaquin L. J. Quintana, Zachary D. Dalebroux, Corrella S. Detweiler   +5 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Intracellular Behaviour of Legionella Non-pneumophila Strains within Three Amoeba Strains, Including Willaertia magna C2c Maky

Pathogens, 2021
Legionellosis, an often-lethal pneumonia, is generally associated with contamination by Legionella pneumophila. This bacterium can persist in the environment and resist chemical treatment when it is internalized by amoebae.
Aurélien Croze, Antoine Carlino, Benjamin Quélard, Adeline Saha, Tiphaine Convert, Jean-Baptiste Eberst, Sandrine Demanèche   +6 more
doaj   +1 more source

Staphylococcus aureus as an intracellular pathogen: the role of small colony variants

, 2009
Increasing evidence indicates that Staphylococcus aureus might be a facultative intracellular pathogen. In particular, certain subpopulations, called small colony variants (SCVs), seem to be well adapted to the intracellular milieu.
Proctor, Richard A, Sendi, Parham
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Staphylococcus aureus suppresses the pentose phosphate pathway in human neutrophils via the adenosine receptor A2aR to enhance intracellular survival

mBio
Staphylococcus aureus propensity for intracellular survival presents a challenge to effectively treat infection, with significant evidence suggesting S. aureus can hijack phagocytes for host dissemination, worsening clinical outcomes.
Emilio G. Vozza, Clíodhna M. Daly, Sinead A. O'Rourke, Hannah K. Fitzgerald, Aisling Dunne, Rachel M. McLoughlin   +5 more
doaj   +1 more source

Intracellular Staphylococcus aureus Modulates Host Central Carbon Metabolism To Activate Autophagy

mSphere, 2018
Staphylococcus aureus is a facultative intracellular pathogen that invades and replicates within many types of phagocytic and nonphagocytic cells. During intracellular infection, S. aureus is capable of subverting xenophagy and escaping to the cytosol of
Natalia Bravo-Santano, James K. Ellis, Luis M. Mateos, Yolanda Calle, Hector C. Keun, Volker Behrends, Michal Letek   +6 more
doaj   +1 more source

Ampicillin Treatment of Intracellular Listeria monocytogenes Triggers Formation of Persistent, Drug-Resistant L-Form Cells

Frontiers in Cellular and Infection Microbiology, 2022
Listeria monocytogenes is an opportunistic intracellular pathogen causing an infection termed listeriosis. Despite the low incidence of listeriosis, the high mortality rate in individuals at risk makes this bacterium one of the most dangerous foodborne ...
Virginie Grosboillot, Isabelle Keller, Chantal Ernst, Martin J. Loessner, Markus Schuppler   +4 more
doaj   +1 more source

Slc11a1 limits intracellular growth of Salmonella enterica sv. Typhimurium by promoting macrophage immune effector functions and impairing bacterial iron acquisition

, 2009
The natural resistance-associated macrophage protein 1, Slc11a1, is a phagolysosomal transporter for protons and divalent ions including iron that confers host protection against diverse intracellular pathogens including Salmonella.
Fang, Ferric C., Nairz, Manfred, Weiss, Günter, Crouch, Marie-Laure V., Barton, Howard C., Fritsche, Gernot   +5 more
core   +1 more source