Results 71 to 80 of about 1,012,172 (301)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Influential Parameters for the Analysis of Intracellular Parasite Metabolomics

mSphere, 2018
Metabolomics is increasingly popular for the study of pathogens. For the malaria parasite Plasmodium falciparum, both targeted and untargeted metabolomics have improved our understanding of pathogenesis, host-parasite interactions, and antimalarial drug ...
Maureen A. Carey, Vincent Covelli, Audrey Brown, Gregory L. Medlock, Mareike Haaren, Jessica G. Cooper, Jason A. Papin, Jennifer L. Guler   +7 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Nuclear processes associated with plant immunity and pathogen susceptibility [PDF]

, 2015
Plants are sessile organisms that have evolved exquisite and sophisticated mechanisms to adapt to their biotic and abiotic environment. Plants deploy receptors and vast signalling networks to detect, transmit and respond to a given biotic threat by ...
Kulagina, Natalja, Huitema, Edgar; id_orcid, Motion, Graham B., Marques Monteiro Amaro, Tiago M.   +3 more
core   +1 more source

Staphylococcus aureus suppresses the pentose phosphate pathway in human neutrophils via the adenosine receptor A2aR to enhance intracellular survival

mBio
Staphylococcus aureus propensity for intracellular survival presents a challenge to effectively treat infection, with significant evidence suggesting S. aureus can hijack phagocytes for host dissemination, worsening clinical outcomes.
Emilio G. Vozza, Clíodhna M. Daly, Sinead A. O'Rourke, Hannah K. Fitzgerald, Aisling Dunne, Rachel M. McLoughlin   +5 more
doaj   +1 more source

Effect of Bacteriophage on the Transcriptional and Translational Expression of Inflammatory Mediators in Chicken Macrophage

The Journal of Poultry Science, 2014
This study was designed to evaluate the effect of bacteriophage on macrophage-mediated inflammatory immune responses against intracellular pathogens.
Juhee Ahn, Song-rae Kim, Lae-Seung Jung, Debabrata Biswas   +3 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Internally controlled real-time PCR method for quantitative species-specific detection and vapA genotyping of Rhodococcus equi [PDF]

, 2006
We developed a novel quantitative real-time PCR (Q-PCR) method for the soil actinomycete Rhodococcus equi, an important horse pathogen and emerging human pathogen.
Makrai, L, D. A. Lewis, Rodríguez-Lázaro, AD, Scortti, MM, Rodríguez-Lázaro, David, Hernandez, Marta, Lewis, DA, Vazquez-Boland, Jose A, M. Hernandez, J. A. Vazquez-Boland, Makrai, Laszlo, U. Fogarty, Scortti, Mariela, Hernández, M, Navas, Jesus, Ocampo-Sosa, A, Vázquez-Boland, JA, J. Navas, Ocampo-Sosa, Alain A, Lewis, Deborah A, Fogarty, U, Fogarty, Ursula, M. Scortti, A. A. Ocampo-Sosa, L. Makrai, Navas, J, D. Rodriguez-Lazaro   +26 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source