Results 61 to 70 of about 1,012,172 (301)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Staphylococcus aureus as an intracellular pathogen: the role of small colony variants

, 2009
Increasing evidence indicates that Staphylococcus aureus might be a facultative intracellular pathogen. In particular, certain subpopulations, called small colony variants (SCVs), seem to be well adapted to the intracellular milieu.
Proctor, Richard A, Sendi, Parham
core   +1 more source

Salmonella enterica Infections Are Disrupted by Two Small Molecules That Accumulate within Phagosomes and Differentially Damage Bacterial Inner Membranes

mBio, 2022
Gram-negative bacteria have a robust cell envelope that excludes or expels many antimicrobial agents. However, during infection, host soluble innate immune factors permeabilize the bacterial outer membrane.
Joseph A. Villanueva, Amy L. Crooks, Toni A. Nagy, Joaquin L. J. Quintana, Zachary D. Dalebroux, Corrella S. Detweiler   +5 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Intracellular Staphylococcus aureus Modulates Host Central Carbon Metabolism To Activate Autophagy

mSphere, 2018
Staphylococcus aureus is a facultative intracellular pathogen that invades and replicates within many types of phagocytic and nonphagocytic cells. During intracellular infection, S. aureus is capable of subverting xenophagy and escaping to the cytosol of
Natalia Bravo-Santano, James K. Ellis, Luis M. Mateos, Yolanda Calle, Hector C. Keun, Volker Behrends, Michal Letek   +6 more
doaj   +1 more source

Intracellular Behaviour of Legionella Non-pneumophila Strains within Three Amoeba Strains, Including Willaertia magna C2c Maky

Pathogens, 2021
Legionellosis, an often-lethal pneumonia, is generally associated with contamination by Legionella pneumophila. This bacterium can persist in the environment and resist chemical treatment when it is internalized by amoebae.
Aurélien Croze, Antoine Carlino, Benjamin Quélard, Adeline Saha, Tiphaine Convert, Jean-Baptiste Eberst, Sandrine Demanèche   +6 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Pathogen burden and cortisol profiles over the day [PDF]

, 2009
Hypothalamic-pituitary-adrenocortical (HPA) regulation in adults is influenced by early psychosocial adversity, but the role of infectious disease history is poorly understood.
Steptoe, A, Shamaei-Tousi, A, Gylfe, Åsa,, Gylfe, A, Henderson, B, Bergstrom, S, Bergström, Sven,   +6 more
core   +1 more source

Chlamydia trachomatis modulates the expression of JAK-STAT signaling components to attenuate the type II interferon response of epithelial cells

mBio
Chlamydia trachomatis has adapted to subvert signaling in epithelial cells to ensure successful intracellular development. Interferon-γ (IFNγ) produced by recruited lymphocytes signals through the JAK/STAT pathway to restrict chlamydial growth in the ...
Francis L. Fontanilla, Joyce A. Ibana, Rey A. Carabeo, Amanda J. Brinkworth   +3 more
doaj   +1 more source

Ampicillin Treatment of Intracellular Listeria monocytogenes Triggers Formation of Persistent, Drug-Resistant L-Form Cells

Frontiers in Cellular and Infection Microbiology, 2022
Listeria monocytogenes is an opportunistic intracellular pathogen causing an infection termed listeriosis. Despite the low incidence of listeriosis, the high mortality rate in individuals at risk makes this bacterium one of the most dangerous foodborne ...
Virginie Grosboillot, Isabelle Keller, Chantal Ernst, Martin J. Loessner, Markus Schuppler   +4 more
doaj   +1 more source