Results 61 to 70 of about 1,064,501 (255)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Individual contributions of exotoxins S and T on internalized P. aeruginosa

Infection and Immunity
Pseudomonas aeruginosa is a high-priority pathogen and significant burden to health care worldwide. Although often regarded as an extracellular pathogen, P.
Zachary J. Resko, Adam V. Thota, Christopher J. Corcoran, David G. Glanville, Seby Edassery, Keith A. Klein, Jonathan P. Allen, Jonathan A. Kirk, Andrew T. Ulijasz, Abby R. Kroken   +9 more
doaj   +1 more source

Ampicillin Treatment of Intracellular Listeria monocytogenes Triggers Formation of Persistent, Drug-Resistant L-Form Cells

Frontiers in Cellular and Infection Microbiology, 2022
Listeria monocytogenes is an opportunistic intracellular pathogen causing an infection termed listeriosis. Despite the low incidence of listeriosis, the high mortality rate in individuals at risk makes this bacterium one of the most dangerous foodborne ...
Virginie Grosboillot, Isabelle Keller, Chantal Ernst, Martin J. Loessner, Markus Schuppler   +4 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Regulation of the Intracellular Pathogen Response by pals Gene Pairs in C. elegans [PDF]

, 2020
The innate immune system is critical in protecting against foreign invaders and can be activated by detection of microbe-associated molecules, as well as detection of the consequences of pathogen infection. In the nematode C.
Bui, Theresa
core   +1 more source

Quantitative three-dimensional imaging of Coxiella burnetii infection by focused ion beam-scanning electron microscopy

Infection and Immunity
Coxiella burnetii is a highly virulent intracellular pathogen and the causative agent of acute and chronic Q fever in humans. Central to its pathogenicity is the Dot/Icm type IV secretion system, which translocates more than 100 effector proteins into ...
Jack M. Botting, Samuel Steiner, Morven Graham, Xinran Liu, Craig R. Roy, Jun Liu   +5 more
doaj   +1 more source

Influential Parameters for the Analysis of Intracellular Parasite Metabolomics

mSphere, 2018
Metabolomics is increasingly popular for the study of pathogens. For the malaria parasite Plasmodium falciparum, both targeted and untargeted metabolomics have improved our understanding of pathogenesis, host-parasite interactions, and antimalarial drug ...
Maureen A. Carey, Vincent Covelli, Audrey Brown, Gregory L. Medlock, Mareike Haaren, Jessica G. Cooper, Jason A. Papin, Jennifer L. Guler   +7 more
doaj   +1 more source

Pathways of host cell exit by intracellular pathogens [PDF]

, 2018
Host cell exit is a critical step in the life-cycle of intracellular pathogens, intimately linked to barrier penetration, tissue dissemination, inflammation, and pathogen transmission.
Hornef, Mathias W., Georg Häcker, Hornef, Mathias Walter, Flieger, Antje, Freddy Frischknecht, Frischknecht, Freddy, Mathias W. Hornef, Pradel, Gabriele, Antje Flieger, Häcker, Georg, Gabriele Pradel, Häcker, Georg A.   +11 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Breathing and burning: metabolic control of alveolar macrophages by intracellular bacterial pathogens

Frontiers in Physiology
Alveolar macrophages (AMs) are the lung’s phagocytic immune sentinels, programmed to maintain homeostasis while defending against inhaled pathogens. AM metabolism is shaped by both developmental origin and the alveolar microenvironment.
Het Adhvaryu, Daniel E. Voth
doaj   +1 more source