Results 41 to 50 of about 1,012,172 (301)

Killing them softly:managing pathogen polymorphism and virulence in spatially variable environments [PDF]

, 2013
Understanding why pathogen populations are genetically variable is vital because genetic variation fuels evolution, which often hampers disease control efforts.
Vale, Pedro F; id_orcid, Vale, Pedro F.
core   +1 more source

Diagnostic methods for intracellular pathogens [PDF]

Clinical Microbiology and Infection, 1996
Diagnosis of infection with Chlamydia pneumoniae is difficult and the optimal diagnostic procedure has yet to be established. C. pneumoniae is more difficult to isolate in tissue culture than C. trachomatis. Attention must be paid to the site from which the specimen is taken, and all specimens should be processed within 24 h or stored at 4 C. Serologic
openaire   +2 more sources

The genome of a pathogenic rhodococcus : cooptive virulence underpinned by key gene acquisitions [PDF]

, 2010
We report the genome of the facultative intracellular parasite Rhodococcus equi, the only animal pathogen within the biotechnologically important actinobacterial genus Rhodococcus. The 5.0-Mb R.
Parkhill Julian, Cherevach, Inna, Iain Macarthur, Sanders Mandy, Leadon, Desmond, Prescott John F., Navas, Jesús, Michal Letek, González Patricia, Tom C. Freeman, Navas Méndez, Jesús, Valero-Rello, Ana, Ruth Fahey, Leadon Desmond, Bentley, Stephen D., Holdstock Jolyon, Ursula Fogarty, Scortti, Mariela M., Hapeshi, Alexia, José A. Vázquez-Boland, Inna Cherevach, Buckley, Tom, Rodríguez, Héctor M., Rodríguez Héctor, Ocampo Alain, Valero-Rello Ana, Fogarty Ursula, Valero Rello, Ana, Prescott, John F., Quail Michael A., Rodríguez, Héctor, Jolyon Holdstock, Alain Ocampo, Sanders, Mandy, Héctor Rodríguez, Fogarty, Ursula, Vázquez-Boland José A., Ana Valero-Rello, MacArthur Iain, Freeman Tom C., González, Patricia, Ocampo, Alain, Ana Valero-Rello, Fahey Ruth, Desmond Leadon, Cherevach Inna, Blanco, Mónica, Mariela M. Scortti, MacArthur, Iain, Vázquez Boland, José A., Bentley Stephen D., John F Prescott, Wim G. Meijer, Quail, Michael A., John F. Prescott, Stephen D. Bentley, Vázquez-Boland, José A., José A Vázquez-Boland, Holdstock, Jolyon, Stephen D Bentley, Letek Michal, Meijer, Wim G., Blanco Mónica, Meijer Wim G., Mónica Blanco, Ocampo Sosa, Alain Antonio, Tom C Freeman, Julian Parkhill, Jolyon Holdstock, Hapeshi Alexia, Tom Buckley, Wim G Meijer, Mandy Sanders, Michael A. Quail, Letek, Michal, Michael A Quail, Alexia Hapeshi, Scortti Mariela M., Parkhill, Julian, Navas Jesús, Patricia González, Mariela M Scortti, González, Patricia Jiménez, Buckley Tom, Freeman, Tom C., Fahey, Ruth, Jesús Navas   +86 more
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A rhodanine agent active against non-replicating intracellular Mycobacterium avium subspecies paratuberculosis. [PDF]

, 2009
BACKGROUND: Antibiotic therapy targeting chronic mycobacterial disease is often ineffective due to problems with the emergence of drug resistance and non-replicating persistent intracellular antibiotic resistant phenotypes.
Hermon-Taylor, J, Hinds Jason, Hinds, J, Bull Tim J, Hermon-Taylor John, Richard Linedale, Bull, TJ, Linedale Richard, Jason Hinds, Tim J Bull, John Hermon-Taylor, Linedale, R   +11 more
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Structural characterisation of the virulence-associated protein VapG from the horse pathogen Rhodococcus equi [PDF]

, 2015
Virulence and host range in Rhodococcus equi depends on the variable pathogenicity island of their virulence plasmids. Notable gene products are a family of small secreted virulence-associated proteins (Vaps) that are critical to intramacrophagic ...
Blagova, Elena V., Okoko, Tebekeme, Dover, Lynn, Wilkinson, Anthony, Dover, Lynn G., Blagova, Elena, Whittingham, Jean L., Whittingham, Jean, Wilkinson, Anthony J.   +8 more
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Proteomic Profiling of Burkholderia thailandensis During Host Infection Using Bio-Orthogonal Noncanonical Amino Acid Tagging (BONCAT)

Frontiers in Cellular and Infection Microbiology, 2018
Burkholderia pseudomallei and B. mallei are the causative agents of melioidosis and glanders, respectively, and are often fatal to humans and animals. Owing to the high fatality rate, potential for spread by aerosolization, and the lack of efficacious ...
Magdalena Franco, Patrik M. D'haeseleer, Steven S. Branda, Megan J. Liou, Yasmeen Haider, Brent W. Segelke, Sahar H. El-Etr   +6 more
doaj   +1 more source

Cryptococcal pathogenic mechanisms: a dangerous trip from the environment to the brain

Memorias do Instituto Oswaldo Cruz, 2018
Cryptococcus neoformans is an opportunistic pathogenic yeast that causes serious infections, most commonly of the central nervous system (CNS). C. neoformans is mainly found in the environment and acquired by inhalation.
Shannon K Esher, Oscar Zaragoza, James Andrew Alspaugh   +2 more
doaj   +1 more source

Plasma membrane-located purine nucleotide transport proteins are key components for host exploitation by microsporidian intracellular parasites [PDF]

, 2014
EH and TAW acknowledge support from the Marie Curie Fellowship Programme (HTTP://cordis.europa.eu/fp7/home_en.html). ERSK, JML and TME acknowledge support from the Wellcome Trust (www.wellcome.ac.uk/).
Eva Heinz (105025), Hirt, R.P., Edmund R. S. Kunji (669696), Williams, Tom A, Goldberg, A.V., Robert P Hirt, Hacker Christian, T Martin Embley, Robert P. Hirt (124609), Kunji, E.R.S., Nakjang, Sirintra, Hirt, Robert, Kunji, Edmund R S, John M. Lucocq (124603), Embley, T. Martin, Christian Hacker (124601), Edmund R S Kunji, Alina V. Goldberg (124596), Heinz, Eva, John Mifsud (669694), Lucocq, John M., Alison Gregory, Embley T. Martin, Dean, P., Hirt, Robert P., Goldberg, Alina V, Heinz, E., Nakjang Sirintra, T. Martin Embley (124611), Williams Tom A., Sirintra Nakjang (124590), Kunji, Edmund R. S., Kunji, Edmund, John M Lucocq, Gregory, Alison, Goldberg, Alina, Goldberg Alina V., Tom A Williams, Tom A. Williams (124587), Gregory, A., Lucocq John M., Embley, T Martin, Paul Dean (35800), Heinz Eva, Dean, Paul; id_orcid, John Mifsud, Williams, Tom A., Lucocq, John M, Hirt Robert P., Alina V Goldberg, Dean, Paul, Hirt, Robert P, Paul Dean, Nakjang, S., Embley, T, Sirintra Nakjang, Gregory Alison, Dean Paul, Goldberg, Alina V., Mifsud, John, Lucocq, John, Williams, T.A., Mifsud John, Christian Hacker, Alison Gregory (669695), Embley, T.M., Williams, Tom, Eva Heinz, Hacker, Christian, Hacker, C., Kunji, Edmund R.S., Mifsud, J., Kunji Edmund R. S.   +72 more
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Study on the Occurrence of Genetic Exchange Among Parasites of the Leishmania mexicana Complex

Frontiers in Cellular and Infection Microbiology, 2020
In Leishmania, genetic exchange has been experimentally demonstrated to occur in the sand fly vector and in promastigote axenic cultures through a meiotic-like process.
Roman Telittchenko, Albert Descoteaux
doaj   +1 more source

Coxiella burnetii Sterol-Modifying Protein Stmp1 Regulates Cholesterol in the Intracellular Niche

mBio, 2022
Coxiella burnetii replicates in a phagolysosome-like vacuole called the Coxiella-containing vacuole (CCV). While host cholesterol readily traffics to the CCV, cholesterol accumulation leads to CCV acidification and bacterial death.
Tatiana M. Clemente, Rochelle Ratnayake, Dhritiman Samanta, Leonardo Augusto, Paul A. Beare, Robert A. Heinzen, Stacey D. Gilk   +6 more
doaj   +1 more source