Results 41 to 50 of about 281,844 (353)

Neglected Zoonotic Diseases: Advances in the Development of Cell-Penetrating and Antimicrobial Peptides against Leishmaniosis and Chagas Disease

Pathogens, 2023
In 2020, the WHO established the road map for neglected tropical diseases 2021–2030, which aims to control and eradicate 20 diseases, including leishmaniosis and Chagas disease. In addition, since 2015, the WHO has been developing a Global Action Plan on
Sara M. Robledo, Silvia Pérez-Silanes, Celia Fernández-Rubio, Ana Poveda, Lianet Monzote, Víctor M. González, Paloma Alonso-Collado, Javier Carrión   +7 more
doaj   +1 more source

Genome-wide analysis reveals loci encoding anti-macrophage factors in the human pathogen burkholderia pseudomallei K96243 [PDF]

, 2010
Burkholderia pseudomallei is an important human pathogen whose infection biology is still poorly understood. The bacterium is endemic to tropical regions, including South East Asia and Northern Australia, where it causes melioidosis, a serious disease ...
Wilkinson Paul A., Dowling, Andrea J., Matthew T G Holden, Richard W. Titball, Nicholas R. Waterfield, Paul A Wilkinson, Titball, Richard W., Quail, MA, Bentley Stephen D., Holden Matthew T. G., Richard W Titball, Bentley, SD, Julia Reger, Quail, Michael A., Waterfield Nicholas R., Stephen D. Bentley, Waterfield, NR, Andrea J Dowling, Stephen D Bentley, Wilkinson, Paul A., Bentley, Stephen D., Holden, Matthew T. G., ffrench-Constant, Richard H., ffrench-Constant Richard H., ffrench-Constant, Richard, Richard H. ffrench-Constant, Paul A. Wilkinson, Matthew T. G. Holden, Michael A. Quail, Michael A Quail, Waterfield, Nicholas R., Dowling Andrea J., Reger, J, Titball Richard W., Nicholas R Waterfield, Reger, Julia, Quail Michael A., Andrea J. Dowling, Andrea J. Dowling, Richard H Ffrench-Constant, Dowling, AJ, Holden, Matthew, Wilkinson, PA, Reger Julia   +43 more
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The Interplay of Host Lysosomes and Intracellular Pathogens [PDF]

Frontiers in Cellular and Infection Microbiology, 2020
Lysosomes are an integral part of the intracellular defense system against microbes. Lysosomal homeostasis in the host is adaptable and responds to conditions such as infection or nutritional deprivation. Pathogens such asMycobacterium tuberculosis(Mtb) andSalmonellaavoid lysosomal targeting by actively manipulating the host vesicular trafficking and ...
Kuldeep Sachdeva, Varadharajan Sundaramurthy   +1 more
openaire   +3 more sources

Brucella effectors NyxA and NyxB target SENP3 to modulate the subcellular localisation of nucleolar proteins

Nature Communications, 2023
The bacterium Brucella abortus is an intracellular pathogen that modulates autophagy in host cells. Here, the authors identify two B. abortus effectors that interact with host protease SENP3, thus promoting cytoplasmic accumulation of nucleolar proteins ...
Arthur Louche, Amandine Blanco, Thais Lourdes Santos Lacerda, Lison Cancade-Veyre, Claire Lionnet, Célia Bergé, Monica Rolando, Frédérique Lembo, Jean-Paul Borg, Carmen Buchrieser, Masami Nagahama, Francine C. A. Gérard, Jean-Pierre Gorvel, Virginie Gueguen-Chaignon, Laurent Terradot, Suzana P. Salcedo   +15 more
doaj   +1 more source

Invasion and persistent intracellular colonization of erythrocytes : A unique parasitic strategy of the emerging pathogen Bartonella [PDF]

, 2001
The expanding genus Bartonella includes zoonotic and human-specific pathogens that can cause a wide range of clinical manifestations. A productive infection allowing bacterial transmission by blood-sucking arthropods is marked by an intraerythrocytic ...
Schulein, R., Gille, C., Yves Hansmann, Hansmann, Y., Dehio, C., Seubert, A., Piemont, Y., Yves Piémont, Christa Lanz, Ralf Schülein, Anja Seubert, Lanz, C., Christoph Dehio, Christian Gille   +13 more
core   +1 more source

No better time to FRET: shedding light on host pathogen interactions [PDF]

, 2010
Understanding the spatio-temporal subversion of host cell signaling by bacterial virulence factors is key to combating infectious diseases. Following a recent study by Buntru and co-workers published in BMC Biology, we review how fluorescence (Forster ...
Leong, J.M., Goguen, J.D., Goguen, JD, Leong, JM, Hayward, RD, Hayward, Richard D.   +5 more
core   +1 more source

Myxobacteria-Derived Outer Membrane Vesicles: Potential Applicability Against Intracellular Infections [PDF]

, 2020
In 2019, it was estimated that 2.5 million people die from lower tract respiratory infections annually. One of the main causes of these infections is Staphylococcus aureus, a bacterium that can invade and survive within mammalian cells. S.
Thomas Kuhn, Fabian Panter, Goes, Adriely, Müller, Rolf, Robert Richter, Garcia, Ronald, Kuhn, Thomas, Richter, Robert, Fuhrmann, Gregor, Alexandra K. Kiemer, Kiemer, Alexandra K., Rolf Müller, Gregor Fuhrmann, Marcus Koch, Philipp Lapuhs, Lapuhs, Philipp, Adriely Goes, Koch, Marcus, Eilien Schulz, Panter, Fabian, Dahlem, Charlotte, Schulz, Eilien, Charlotte Dahlem, Ronald Garcia   +23 more
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Comprehensive Single Cell Analyses of the Nutritional Environment of Intracellular Salmonella enterica

Frontiers in Cellular and Infection Microbiology, 2021
The facultative intracellular pathogen Salmonella enterica Typhimurium (STM) resides in a specific membrane-bound compartment termed the Salmonella-containing vacuole (SCV).
Jennifer Röder, Pascal Felgner, Michael Hensel, Michael Hensel   +3 more
doaj   +1 more source

Cross-regulation in a three-component cell envelope stress signaling system of Brucella

mBio, 2023
A multi-layered structure known as the cell envelope separates the controlled interior of bacterial cells from a fluctuating physical and chemical environment.
Xingru Chen, Melene A. Alakavuklar, Aretha Fiebig, Sean Crosson   +3 more
doaj   +1 more source

Proteomic Profiling of Burkholderia thailandensis During Host Infection Using Bio-Orthogonal Noncanonical Amino Acid Tagging (BONCAT)

Frontiers in Cellular and Infection Microbiology, 2018
Burkholderia pseudomallei and B. mallei are the causative agents of melioidosis and glanders, respectively, and are often fatal to humans and animals. Owing to the high fatality rate, potential for spread by aerosolization, and the lack of efficacious ...
Magdalena Franco, Patrik M. D'haeseleer, Steven S. Branda, Megan J. Liou, Yasmeen Haider, Brent W. Segelke, Sahar H. El-Etr   +6 more
doaj   +1 more source