Results 31 to 40 of about 281,844 (353)

Exploitation of the Host Ubiquitin System: Means by Legionella pneumophila

Frontiers in Microbiology, 2021
Ubiquitination is a commonly used post-translational modification (PTM) in eukaryotic cells, which regulates a wide variety of cellular processes, such as differentiation, apoptosis, cell cycle, and immunity.
Jingjing Luo, Lidong Wang, Lei Song, Zhao-Qing Luo   +3 more
doaj   +1 more source

A randomized multiplex CRISPRi-Seq approach for the identification of critical combinations of genes

eLife, 2023
Identifying virulence-critical genes from pathogens is often limited by functional redundancy. To rapidly interrogate the contributions of combinations of genes to a biological outcome, we have developed a multiplex, randomized CRISPR interference ...
Nicole A Ellis, Kevin S Myers, Jessica Tung, Anne Davidson Ward, Kathryn Johnston, Katherine E Bonnington, Timothy J Donohue, Matthias P Machner   +7 more
doaj   +1 more source

Emerging concepts in the pathogenesis of theStreptococcus pneumoniae: From nasopharyngeal colonizer to intracellular pathogen [PDF]

Cellular Microbiology, 2019
Karthik Subramanian, Birgitta Henriques-Normark, Staffan Normark   +2 more
exaly   +2 more sources

Atomic Structure of IglD Demonstrates Its Role as a Component of the Baseplate Complex of the Francisella Type VI Secretion System

mBio, 2022
Francisella tularensis, a Tier 1 select agent of bioterrorism, contains a type VI secretion system (T6SS) encoded within the Francisella pathogenicity island (FPI), which is critical for its pathogenesis.
Xiaoyu Liu, Daniel L. Clemens, Bai-Yu Lee, Xue Yang, Z. Hong Zhou, Marcus A. Horwitz   +5 more
doaj   +1 more source

Pathogenic mechanisms of intracellular bacteria [PDF]

Current Opinion in Infectious Diseases, 2017
Purpose of review We wished to overview recent data on a subset of epigenetic changes elicited by intracellular bacteria in human cells. Reprogramming the gene expression pattern of various host cells may facilitate bacterial growth, survival, and spread.
Niller Hans Helmut, Masa Roland, Venkei Annamária, Mészáros Sándor, Minárovits János   +4 more
openaire   +3 more sources

Brucella: not your ‘typical’ intracellular pathogen [PDF]

Microbiology Australia, 2020
Currently the genus Brucella consists of a group of bacteria that are genetically monospecific yet phenotypically diverse, and a recent genetic and phenotypic divergent group known as ‘atypical' Brucellae.
Nicky Buller, Anthony L Keyburn
doaj  

Q Fever Vaccine Development: Current Strategies and Future Considerations

Pathogens, 2021
Q fever is a zoonotic disease caused by the intracellular pathogen Coxiella burnetii. This disease typically manifests as a self-limiting, febrile illness known as acute Q fever.
Carrie Mae Long
doaj   +1 more source

The Steroid Catabolic Pathway of the Intracellular Pathogen Rhodococcus equi Is Important for Pathogenesis and a Target for Vaccine Development [PDF]

, 2011
Rhodococcus equi causes fatal pyogranulomatous pneumonia in foals and immunocompromised animals and humans. Despite its importance, there is currently no effective vaccine against the disease. The actinobacteria R.
Hessels G. I., L. Dijkhuizen, Dijkhuizen, L.,, R van der Geize, Grommen A. W. F., G. I. Hessels, R. van der Geize, Grommen, A.W.F.,, L Dijkhuizen, Geize, R. van der,, Dijkhuizen, L., Hessels, G. I., A W F Grommen, Grommen, A. W. F., Jacobs, A.A.C.,, A A C Jacobs, Dijkhuizen, L.; id_orcid, A. A. C. Jacobs, Jacobs, A. A. C., Dijkhuizen L., van der Geize, R., G I Hessels, Jacobs A. A. C., Hessels, G.I.,, A. W. F. Grommen, van der Geize R.   +25 more
core   +1 more source

Establishing the intracellular niche of obligate intracellular vacuolar pathogens

Frontiers in Cellular and Infection Microbiology, 2023
Obligate intracellular pathogens occupy one of two niches – free in the host cell cytoplasm or confined in a membrane-bound vacuole. Pathogens occupying membrane-bound vacuoles are sequestered from the innate immune system and have an extra layer of protection from antimicrobial drugs. However, this lifestyle presents several challenges.
Tatiana M. Clemente, Rajendra K. Angara, Stacey D. Gilk   +2 more
openaire   +3 more sources

Hijacking host cell highways: manipulation of the host actin cytoskeleton by obligate intracellular bacterial pathogens

Frontiers in Cellular and Infection Microbiology, 2016
Intracellular bacterial pathogens replicate within eukaryotic cells and display unique adaptations that support key infection events including invasion, replication, immune evasion, and dissemination.
Punsiri M Colonne, Caylin G Winchell, Daniel E Voth   +2 more
doaj   +1 more source