Results 11 to 20 of about 281,844 (353)

Sequestration of host metabolism by an intracellular pathogen [PDF]

eLife, 2016
For intracellular pathogens, residence in a vacuole provides a shelter against cytosolic host defense to the cost of limited access to nutrients. The human pathogen Chlamydia trachomatis grows in a glycogen-rich vacuole.
Lena Gehre, Olivier Gorgette, Stéphanie Perrinet, Marie-Christine Prevost, Mathieu Ducatez, Amanda M Giebel, David E Nelson, Steven G Ball, Agathe Subtil   +8 more
doaj   +7 more sources

Intra-ChIP: studying gene regulation in an intracellular pathogen [PDF]

Current Genetics, 2016
Intracellular bacteria that reside within a host cell use a variety of strategies to exploit this unique niche. While these organisms are technically challenging to study in the context of an infected host cell, recent advances have led to an improved ...
Ming Tan
exaly   +4 more sources

Lysine methylation shields an intracellular pathogen from ubiquitylation and autophagy. [PDF]

Sci Adv, 2021
Many intracellular pathogens avoid detection by their host cells. However, it remains unknown how they avoid being tagged by ubiquitin, an initial step leading to antimicrobial autophagy. Here, we show that the intracellular bacterial pathogen Rickettsia
Engström P, Burke TP, Tran CJ, Iavarone AT, Welch MD.   +4 more
europepmc   +2 more sources

Definition of intracellular pathogens [PDF]

Clinical Microbiology and Infection, 1996
Most microorganisms are destroyed by the host tissues through processes which usually involve phagocytosis and lysosomal disruption. However, some organisms are capable of growing inside macrophages and avoiding destruction. This paper describes the normal phagocytic process and how it is avoided by certain viruses, bacteria and protozoa, and the ...
J Orfila
openalex   +3 more sources

Dissecting antimicrobial logic: species-specific strategies for intracellular pathogen defense [PDF]

mSphere
Control of intracellular pathogens is a critical element of host defense. Defining the molecular mechanisms by which the host restricts or eliminates these pathogens may inform the development of novel immunotherapeutics and antimicrobial strategies ...
Bryan D. Bryson
doaj   +2 more sources

An Intracellular Pathogen Response Pathway Promotes Proteostasis in C. elegans. [PDF]

Curr Biol, 2017
Maintenance of protein homeostasis, or proteostasis, is crucial for organismal health. Disruption of proteostasis can lead to the accumulation of protein aggregates, which are associated with aging and many human diseases such as Alzheimer's disease [1-3]
Reddy KC, Dror T, Sowa JN, Panek J, Chen K, Lim ES, Wang D, Troemel ER.   +7 more
europepmc   +2 more sources

Dynamic Growth and Shrinkage of the Salmonella-Containing Vacuole Determines the Intracellular Pathogen Niche.

Cell Rep, 2019
International audienceSalmonella is a human and animal pathogen that causes gastro-enteric diseases. The key to Salmonella infection is its entry into intestinal epithelial cells, where the bacterium resides within a Salmonella-containing vacuole (SCV ...
Stévenin V, Chang YY, Le Toquin Y, Duchateau M, Gianetto QG, Luk CH, Salles A, Sohst V, Matondo M, Reiling N, Enninga J.   +10 more
europepmc   +2 more sources

Orientia tsutsugamushi: A neglected but fascinating obligate intracellular bacterial pathogen

PLoS Pathogens, 2017
Our understanding of the molecular systems that bacteria have developed over millennia of evolutionary tinkering remains limited compared with the incredible diversity of the bacterial kingdom.
Jeanne Salje
exaly   +3 more sources

Correction: Intracellular pathogen sensor NOD2 programs macrophages to trigger Notch1 activation. [PDF]

J Biol Chem, 2020
Bansal K, Balaji KN.
europepmc   +3 more sources

High-Resolution Crystal Structure of RpoS Fragment including a Partial Region 1.2 and Region 2 from the Intracellular Pathogen Legionella pneumophila

Crystals, 2018
Legionella pneumophila RpoS (LpRpoS), an alternative sigma factor of RNA polymerase (RNAP), is essential for virulence and stress resistance. To investigate the mechanism of RpoS in the intracellular pathogen L.
Nannan Zhang, Mingzhu Wang, Honghua Ge   +2 more
exaly   +3 more sources