Results 51 to 60 of about 1,012,172 (301)

Parallel Exploitation of Diverse Host Nutrients Enhances Salmonella Virulence [PDF]

, 2013
Pathogen access to host nutrients in infected tissues is fundamental for pathogen growth and virulence, disease progression, and infection control. However, our understanding of this crucial process is still rather limited because of experimental and ...
Burton, Neil A, Mazé, Alain, Beatrice Claudi (126116), Dirk Bumann (126124), Dirk Bumann, Schmidt Alexander, Burton Neil A., Farhan Hesso, Steeb Benjamin, Claudi Beatrice, Bumann Dirk, Alexander Schmidt, Hesso Farhan, Mazé Alain, Benjamin Steeb (148560), Tienz Petra, Neil A. Burton (407008), Beatrice Claudi, Alexander Schmidt (68515), Petra Tienz, Alain Mazé, Hesso Farhan (407009), Alain Mazé (126117), Neil A Burton, Claudi, Beatrice, Petra Tienz (291552), Tienz, Petra, Farhan, Hesso, Burton, Neil A., Bumann, Dirk, Benjamin Steeb, Steeb, Benjamin, Schmidt, Alexander   +32 more
core   +2 more sources

Molecular motors hijacking by intracellular pathogens [PDF]

Cellular Microbiology, 2006
Cargoes are transported intracellularly along cytoskeletal tracks composed of actin or tubulin. Their movement involves the action of molecular motor proteins that generate directed movement along microtubules or actin filaments. The three classes of molecular motors--kinesins, dyneins and myosins--are involved in a multiplicity of biological movements
Henry, T., Gorvel, J.P., Meresse, S.
openaire   +3 more sources

The Interplay of Host Lysosomes and Intracellular Pathogens [PDF]

Frontiers in Cellular and Infection Microbiology, 2020
Lysosomes are an integral part of the intracellular defense system against microbes. Lysosomal homeostasis in the host is adaptable and responds to conditions such as infection or nutritional deprivation. Pathogens such asMycobacterium tuberculosis(Mtb) andSalmonellaavoid lysosomal targeting by actively manipulating the host vesicular trafficking and ...
Kuldeep Sachdeva, Varadharajan Sundaramurthy   +1 more
openaire   +3 more sources

An intracellular bacterial pathogen triggers RIG-I/MDA5-dependent necroptosis

Current Research in Microbial Sciences
RIG-I and MDA5 are members of RIG-I-like receptors (RLRs) that detect viral RNA within the cytoplasm and subsequently initiate antiviral immune responses.
Hang Xu, Huili Li, Boguang Sun, Li Sun
doaj   +1 more source

Intracellular innate resistance to bacterial pathogens [PDF]

Cellular Microbiology, 2006
Mammalian innate immunity stimulates antigen-specific immune responses and acts to control infection prior to the onset of adaptive immunity. Some bacterial pathogens replicate within the host cell and are therefore sheltered from some protective aspects of innate immunity such as complement.
Radtke, Andrea Lynn, O'Riordan, Mary X. D.   +1 more
openaire   +3 more sources

Intracellular phase for an extracellular bacterial pathogen: MgtC shows the way

, 2015
Pseudomonas aeruginosa is an extracellular pathogen known to impair host phagocytic functions. However, our recent results identify MgtC as a novel actor in P.
Audrey Bernut, Bernut, Audrey, Belon, Claudine, Bleves, Sophie, Claudine Belon, Chantal Soscia, Sophie Bleves, Anne-Béatrice Blanc-Potard, Blanc-Potard, Anne-Béatrice, Soscia, Chantal   +9 more
core   +1 more source

A Genital Infection-Attenuated Chlamydia muridarum Mutant Infects the Gastrointestinal Tract and Protects against Genital Tract Challenge

mBio, 2020
Chlamydia spp. productively infect mucosal epithelial cells of multiple anatomical sites, including the conjunctiva, lungs, gastrointestinal (GI) tract, and urogenital tract.
Sandra G. Morrison, Amanda M. Giebel, Evelyn Toh, Arkaprabha Banerjee, David E. Nelson, Richard P. Morrison   +5 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Slc11a1 limits intracellular growth of Salmonella enterica sv. Typhimurium by promoting macrophage immune effector functions and impairing bacterial iron acquisition

, 2009
The natural resistance-associated macrophage protein 1, Slc11a1, is a phagolysosomal transporter for protons and divalent ions including iron that confers host protection against diverse intracellular pathogens including Salmonella.
Fang, Ferric C., Nairz, Manfred, Weiss, Günter, Crouch, Marie-Laure V., Barton, Howard C., Fritsche, Gernot   +5 more
core   +1 more source