Results 91 to 100 of about 281,844 (353)

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Quantitative three-dimensional imaging of Coxiella burnetii infection by focused ion beam-scanning electron microscopy

Infection and Immunity
Coxiella burnetii is a highly virulent intracellular pathogen and the causative agent of acute and chronic Q fever in humans. Central to its pathogenicity is the Dot/Icm type IV secretion system, which translocates more than 100 effector proteins into ...
Jack M. Botting, Samuel Steiner, Morven Graham, Xinran Liu, Craig R. Roy, Jun Liu   +5 more
doaj   +1 more source

The tomato Prf complex is a molecular trap for bacterial effectors based on Pto transphosphorylation [PDF]

, 2013
The bacteria Pseudomonas syringae is a pathogen of many crop species and one of the model pathogens for studying plant and bacterial arms race coevolution.
John P Rathjen, Rathjen, John P, Alexi L. Balmuth, Vardis Ntoukakis, Balmuth, Alexi L, Balmuth, Alexi L., Ra M. E. Jones, Tatiana S Mucyn, Gutierrez, Jose R., Jose R. Gutierrez, Mucyn, Tatiana S, Alexi L. Balmuth, Vardis Ntoukakis (223009), Ntoukakis Vardis, Jose R. Gutierrez (278825), Ntoukakis, Vardis, Alexi L. Balmuth (215165), John P. Rathjen (232061), Jose R Gutierrez, Gutierrez, Jose R, Balmuth Alexi L., Vardis Ntoukakis, Jones, Alexandra M., Tatiana S. Mucyn (278824), Jones, Alexandra M. E, Tatiana S. Mucyn¤a, Rathjen John P., Rathjen, John P., Alexi L Balmuth, Jones Alexandra M. E., Mucyn, Tatiana S., John P. Rathjen*¤b, Alexandra M. E. Jones, Gutierrez Jose R., John P. Rathjen, Alexandra M. E. Jones (50010), Tatiana S. Mucyn, Alexandra M E Jones, Mucyn Tatiana S.   +38 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Immunity to Intracellular Salmonella Depends on Surface-associated Antigens [PDF]

, 2012
Invasive Salmonella infection is an important health problem that is worsening because of rising antimicrobial resistance and changing Salmonella serovar spectrum.
Rizos Konstantin, Beatrice Claudi (126116), Dirk Bumann (126124), Dirk Bumann, Somedutta Barat (126107), Barat, Somedutta, Rizos, K., Bumann, D., Schemmer, Anne K, Claudi Beatrice, Neil Burton (126123), Anne K Schemmer, Barat Somedutta, Dennis Kirchhoff (126121), Somedutta Barat, Alexander Schmidt (68515), Kirchhoff, D., Alain Mazé, Willer, Yvonne, Anne K. Schemmer (126119), Kirchhoff Dennis, Rizos, Konstantin, Dennis Kirchhoff, Bumann, Dirk, Burton Neil, Schemmer, A., Claudi, B., Mazé, Alain, Schmidt Alexander, Schemmer Anne K., Yvonne Willer (126110), Konstantin Rizos (126113), Willer Yvonne, Yvonne Willer, Willer, Y., Burton, Neil, Bumann Dirk, Alexander Schmidt, Mazé Alain, Beatrice Claudi, Schmidt, A., Alain Mazé (126117), Mazé, A., Claudi, Beatrice, Kirchhoff, Dennis, Barat, S., Konstantin Rizos, Burton, N., Schemmer, Anne K., Schmidt, Alexander, Neil Burton   +50 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Animal models for oral transmission of Listeria monocytogenes

Frontiers in Cellular and Infection Microbiology, 2014
Listeria monocytogenes has been recognized as a food borne pathogen in humans since the 1980s, but we still understand very little about oral transmission of L. monocytogenes or the host factors that determine susceptibility to gastrointestinal infection,
Sarah E F D'Orazio
doaj   +1 more source

Apoptosis assessment in high-content and high-throughput screening assays

BioTechniques, 2021
Here the authors describe the development of AUTOptosis, an economical and rapid apoptosis monitoring method suitable for high-content and high-throughput screening assays.
Céline Rens, Tirosh Shapira, Sandra Peña-Diaz, Joseph D Chao, Tom Pfeifer, Yossef Av-Gay   +5 more
doaj   +1 more source

Mycoredoxins Are Required for Redox Homeostasis and Intracellular Survival in the Actinobacterial Pathogen Rhodococcus equi [PDF]

, 2022
[EN] Rhodococcus equi is a facultative intracellular pathogen that can survive within macrophages of a wide variety of hosts, including immunosuppressed humans.
Mourenza Flórez, Álvaro, Mateos Delgado, Luis Mariano, Bravo Santano, Natalia, Letek Polberg, Michal, Pradal Álvarez-Prida, Inés, Gil Santos, José Antonio   +5 more
core   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source