Results 111 to 120 of about 1,064,501 (255)

A sensor histidine kinase from a plant-endosymbiont bacterium restores the virulence of a mammalian intracellular pathogen. [PDF]

Microb Pathog, 2023
Chaves-Olarte E, Meza-Torres J, Herrera-Rodríguez F, Lizano-González E, Suárez-Esquivel M, Baker KS, Rivas-Solano O, Ruiz-Villalobos N, Villalta-Romero F, Cheng HP, Walker GC, Cloeckaert A, Thomson NR, Frisan T, Moreno E, Guzmán-Verri C.   +15 more
europepmc   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Shaping the CD4+ memory immune response against tuberculosis: the role of antigen persistence, location and multi-functionality

Biomolecular Concepts, 2012
Effective vaccination against intracellular pathogens, such as tuberculosis (TB), relies on the generation and maintenance of CD4 memory T cells. An incomplete understanding of the memory immune response has hindered the rational design of a new, more ...
Ancelet Lindsay, Kirman Joanna
doaj   +1 more source

Correction: Sodium levels and grazing pressure shape natural communities of the intracellular pathogen Legionella. [PDF]

Microbiome, 2023
Bergman O, Be'eri-Shlevin Y, Ninio S.
europepmc   +1 more source

Metabolic host response to intracellular infections

, 2018
The interaction between intracellular bacterial pathogens with the host immune response can result in multiple outcomes that range from asymptomatic clearance to the establishment of infection. At its core, these interactions result in multiple metabolic
Torrado, Egídio, Pereira, Inês M., Inês M. Pereira, Ferreira, Catarina Machado, Ana Margarida Barbosa, Catarina M. Ferreira, Egídio Torrado, Barbosa, Ana Margarida Martins   +7 more
core   +1 more source

Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoimmune diseases in FSHD remain unclear.
Jonathan Pini, Giulia Tammam, Andra Ezaru, Manuela Gambella, Benoît Sanson, Luisa Villa, Michele Cavalli, Mihai‐Bogdan Ioncea, Angela Puma, Sabrina Sacconi   +9 more
wiley   +1 more source

Brucella abortus histidine auxotrophs are copper sensitive

Journal of Bacteriology
Despite decades of investigation into bacterial pathogens, the conditions met by intracellular bacteria are still unclear. These conditions can include access to nutrients, such as amino acids, and exposure to toxic compounds, like copper. To investigate
Charline Focant, Agnès Roba, Elisabeth Wanlin, Katy Poncin, Xavier De Bolle   +4 more
doaj   +1 more source

Similarities in the induction of the intracellular pathogen response in Caenorhabditis elegans and the type I interferon response in mammals. [PDF]

Bioessays, 2023
Lažetić V, Batachari LE, Russell AB, Troemel ER.   +3 more
europepmc   +1 more source

Nanomedicine as an emerging approach against intracellular pathogens

, 2011
Andrea L Armstead1–3, Bingyun Li1–31Biomaterials, Bioengineering and Nanotechnology Laboratory, Department of Orthopedics, School of Medicine, West Virginia University, Morgantown, WV; 2Pharmaceutical and Pharmacological Sciences ...
Armstead AL, Li B
core  

Mutualist-pathogen co-colonization modulates phosphoinositide signatures at host intracellular interfaces. [PDF]

The host membrane that surrounds intracellular microbes forms a critical interface, influencing whether interactions result in mutualism or pathogenesis.

core   +6 more sources