Results 101 to 110 of about 524,061 (304)

Targeting TRPV4 to restore glymphatic system function and alleviate cerebral edema in ischemic stroke

Brain Pathology, EarlyView.
After ischemic stroke, TRPV4 activation induces cerebral edema through the TRPV4‐RhoA‐MMP9 axis: RhoA upregulates MMP9, which cleaves β‐DG to impair membrane anchoring. Subsequent β‐DG loss triggers AQP4 depolarization, disrupting GS‐mediated water homeostasis.
Yongchuan Li, Haiping Zhou, Jiaxin Xie, Mingjia Yu, Guanyu Ye, Yuzhen Zhang, Zhentong Li, Kunxue Zhang, Jingwen Wu, Sheng Xiao, Shuxin Zeng, Yuan Chang, Kaibin Huang, Suyue Pan   +13 more
wiley   +1 more source

Spontaneous Intracerebral Hemorrhage: Etiology and Yearly Prognostic Factors

Türk Nöroloji Dergisi, 2012
OBJECTIVE: Objectıve: To assess the risk factors in patients with history of spontaneous intracerebral hematoma, to determine the effects of these risk factors on mortality and morbidity and recurrence rate during 12-month follow up period, to ...
İlkay Tekinarslan, Sibel Güler, Ufuk Utku   +2 more
doaj   +1 more source

Experimental Parkinsonism induced by tetanus toxin injected into basal ganglia

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Local inhibitory circuits and long‐range inhibitory projections within the interconnected basal ganglia nuclei are critical for control of voluntary movement and pathophysiology of different extrapyramidal movement disorders.
Patrik Meglić, Petra Šoštarić, Davor Virag, Ana Knezović, Nikola Habek, Ornella Rossetto, Ivica Matak   +6 more
wiley   +1 more source

The Frequency of Recurrence in Primary Hypertensive Intracerebral Hemorrhage

Journal of Research in Medical Sciences, 2006
Background: Primary intracerebral Hemorrhage (PICH) is a devasting illness with high early mortality which causes 10 -12 percent of stroke cases. Survivors of PICH are at risk for recurrence of hemorrhage.
SA Mousavi, SM Nourian, M Zare
doaj  

MicroRNA-126-3p Attenuates Intracerebral Hemorrhage-Induced Blood-Brain Barrier Disruption by Regulating VCAM-1 Expression

Frontiers in Neuroscience, 2019
Background miR-126 is closely related to the occurrence of various complications after intracerebral hemorrhage (ICH), but the molecular mechanism is not fully elucidated.
Xi Fu, Tiesheng Niu, Xiaodong Li
semanticscholar   +1 more source

Complications and Economic Burden of Surgery in Chronic Rhinosinusitis With Nasal Polyps: An Observational Cohort Study Using Swedish Register Data

Clinical Otolaryngology, EarlyView.
ABSTRACT Introduction There is a lack of comprehensive data on complications following sinus surgery (SS) in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). This study aimed to estimate the prevalence of SS‐related complications in CRSwNP patients and examine patient characteristics, predictors of revision surgery, healthcare use, and ...
Petter Olsson, Christoph Abé, Maija Wolf, Mathias Lilja, Tina Maio‐Twofoot, Ola Sunnergren, Pernilla Sahlstrand‐Johnson   +6 more
wiley   +1 more source

Deep Learning for Automated Measurement of Hemorrhage and Perihematomal Edema in Supratentorial Intracerebral Hemorrhage

Stroke, 2019
Supplemental Digital Content is available in the text. Background and Purpose— Volumes of hemorrhage and perihematomal edema (PHE) are well-established biomarkers of primary and secondary injury, respectively, in spontaneous intracerebral hemorrhage.
R. Dhar, G. Falcone, Yasheng Chen, Ali Hamzehloo, Elayna P. Kirsch, Rommell B. Noche, K. Roth, J. Acosta, A. Ruiz, C. Phuah, D. Woo, T. Gill, K. Sheth, Jin-Moo Lee   +13 more
semanticscholar   +1 more source

Dysregulation of Rho‐Associated Coiled‐Coil Protein Kinase1 Depletes Neural Stem Cell Pool and Impairs Hippocampal Neurogenesis After Traumatic Brain Injury

Cell Proliferation, EarlyView.
Following TBI, hippocampal neurogenesis in mice is impaired and affects cognitive function. This impairment is associated with the upregulation of p‐AKT/AKT mediated by ROCK1. ABSTRACT Traumatic brain injury (TBI) represents a global health burden, often resulting in persistent neurological deficits due to impaired hippocampal neurogenesis ...
Chaoqun Yao, Long Jin, Jun Zhong, Qianying Huang, Zhongwei Bao, Shaolong Zhou, Chaohua Wang, Huanhuan Li, Xiaowei Yuan, Zhen Wang, Ning Du, Jingxuan Yu, Huanran Chen, Xuyang Zhang, Hongfei Ge, Jianheng Wu   +15 more
wiley   +1 more source

The fetal neurologist: Strategies to improve training, practice, and clinical care

Developmental Medicine &Child Neurology, EarlyView.
Abstract Fetal neurology addresses counselling parents on the clinical significance of brain anomalies encountered in their fetus, including disruptive lesions (i.e. stroke, periventricular haemorrhagic infarction, and infection), and genetically based cortical (i.e.
Tally Lerman‐Sagie, Anthony R. Hart
wiley   +1 more source

Abnormal dynamic functional connectivity in young nondisabling intracerebral hemorrhage patients

Annals of Clinical and Translational Neurology
Objective Previous resting‐state functional magnetic resonance imaging studies on intracerebral hemorrhage patients have focused more on the static characteristics of brain activity, while the time‐varying effects during scanning have received less ...
Dan Yang, Xiangqi Luo, Shengjun Sun, Xue Zhang, Fengxia Zhang, Xingquan Zhao, Jian Zhou   +6 more
doaj   +1 more source